FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108918615> ?p ?o ?g. }

• W2108918615 endingPage "H441" @default.
• W2108918615 startingPage "H434" @default.
• W2108918615 abstract "Various mechanisms have been suggested to explain cardiac force-length Ca2+ relations. The existence of a cooperativity mechanism, whereby cross-bridge (XB) recruitment is affected by the number of active XBs, suggests that the force response to length oscillations should lag length oscillations. Consequently, the oscillatory force response should be larger during shortening than during lengthening. To test this prediction, force responses to large-sarcomere length (SL) oscillations (36.7 +/- 16.0 nm) at different SLs (n = 6) and frequencies (n = 7) were studied in intact tetanized trabeculae dissected from rat right ventricle (n = 13). Stable tetani were obtained by utilizing 30 microM cyclopiazonic acid in Krebs-Henseleit solution containing 6 mM extracellular Ca(2+) at 25 degrees C. SL was measured by laser diffraction techniques (Dalsa). Force was measured by silicone strain gauge. Instantaneous dynamic stiffness during large oscillations was measured by superimposing additional fast (50 or 200 Hz) and small-amplitude (2.25 +/- 0.25 nm) oscillations. The force responses lagged the SL oscillations at slow frequencies (112 +/- 41 ms at 1 Hz), and counterclockwise hystereses were obtained in the force-length plane: the force was higher during shortening than during lengthening. The delay in the force response decreased as the frequency of the SL oscillation was increased. Clockwise hysteresis, where the force preceded the SL, was obtained at frequencies >4 Hz. Similar hysteresis characteristics were obtained in the force-SL and stiffness-SL planes. Maximal lag was observed at the shortest SL, and the delay decreased with sarcomere elongation: 131.1 +/- 31.7 ms at 1.78 +/- 0.03 microm vs. 14.7 +/- 18.5 ms at 1.99 +/- 0.015 microm. The results establish the ability of cardiac fiber to adapt XB recruitment to changes in prevailing loading conditions. This study supports the stipulated existence of a cooperativity mechanism that regulates XB recruitment and highlights an additional method to characterize regulation of the force-length relation." @default.
• W2108918615 created "2016-06-24" @default.
• W2108918615 creator A5002399354 @default.
• W2108918615 creator A5021648941 @default.
• W2108918615 date "2004-01-01" @default.
• W2108918615 modified "2023-10-06" @default.
• W2108918615 title "Hystereses in the force-length relation and regulation of cross-bridge recruitment in tetanized rat trabeculae" @default.
• W2108918615 cites W100430351 @default.
• W2108918615 cites W1485537415 @default.
• W2108918615 cites W1967107251 @default.
• W2108918615 cites W1970195157 @default.
• W2108918615 cites W1981693253 @default.
• W2108918615 cites W1996288114 @default.
• W2108918615 cites W2001616350 @default.
• W2108918615 cites W2008186189 @default.
• W2108918615 cites W2019718894 @default.
• W2108918615 cites W2020840142 @default.
• W2108918615 cites W2026362533 @default.
• W2108918615 cites W2035893537 @default.
• W2108918615 cites W2038559261 @default.
• W2108918615 cites W2044023393 @default.
• W2108918615 cites W2048593108 @default.
• W2108918615 cites W2054808162 @default.
• W2108918615 cites W2071731964 @default.
• W2108918615 cites W2079198684 @default.
• W2108918615 cites W2079341009 @default.
• W2108918615 cites W2117853554 @default.
• W2108918615 cites W2128706302 @default.
• W2108918615 cites W2131359600 @default.
• W2108918615 cites W2143952020 @default.
• W2108918615 cites W2147915622 @default.
• W2108918615 cites W2150878264 @default.
• W2108918615 cites W2155543505 @default.
• W2108918615 cites W2184757188 @default.
• W2108918615 cites W2323721228 @default.
• W2108918615 cites W2409974174 @default.
• W2108918615 cites W2419282562 @default.
• W2108918615 doi "https://doi.org/10.1152/ajpheart.00354.2003" @default.
• W2108918615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14500129" @default.
• W2108918615 hasPublicationYear "2004" @default.
• W2108918615 type Work @default.
• W2108918615 sameAs 2108918615 @default.
• W2108918615 citedByCount "10" @default.
• W2108918615 countsByYear W21089186152016 @default.
• W2108918615 crossrefType "journal-article" @default.
• W2108918615 hasAuthorship W2108918615A5002399354 @default.
• W2108918615 hasAuthorship W2108918615A5021648941 @default.
• W2108918615 hasConcept C105702510 @default.
• W2108918615 hasConcept C120665830 @default.
• W2108918615 hasConcept C121332964 @default.
• W2108918615 hasConcept C12554922 @default.
• W2108918615 hasConcept C134018914 @default.
• W2108918615 hasConcept C158617107 @default.
• W2108918615 hasConcept C180205008 @default.
• W2108918615 hasConcept C185592680 @default.
• W2108918615 hasConcept C192562407 @default.
• W2108918615 hasConcept C207200792 @default.
• W2108918615 hasConcept C2776050358 @default.
• W2108918615 hasConcept C2778439541 @default.
• W2108918615 hasConcept C2779996123 @default.
• W2108918615 hasConcept C55493867 @default.
• W2108918615 hasConcept C68731436 @default.
• W2108918615 hasConcept C86803240 @default.
• W2108918615 hasConceptScore W2108918615C105702510 @default.
• W2108918615 hasConceptScore W2108918615C120665830 @default.
• W2108918615 hasConceptScore W2108918615C121332964 @default.
• W2108918615 hasConceptScore W2108918615C12554922 @default.
• W2108918615 hasConceptScore W2108918615C134018914 @default.
• W2108918615 hasConceptScore W2108918615C158617107 @default.
• W2108918615 hasConceptScore W2108918615C180205008 @default.
• W2108918615 hasConceptScore W2108918615C185592680 @default.
• W2108918615 hasConceptScore W2108918615C192562407 @default.
• W2108918615 hasConceptScore W2108918615C207200792 @default.
• W2108918615 hasConceptScore W2108918615C2776050358 @default.
• W2108918615 hasConceptScore W2108918615C2778439541 @default.
• W2108918615 hasConceptScore W2108918615C2779996123 @default.
• W2108918615 hasConceptScore W2108918615C55493867 @default.
• W2108918615 hasConceptScore W2108918615C68731436 @default.
• W2108918615 hasConceptScore W2108918615C86803240 @default.
• W2108918615 hasIssue "1" @default.
• W2108918615 hasLocation W21089186151 @default.
• W2108918615 hasLocation W21089186152 @default.
• W2108918615 hasOpenAccess W2108918615 @default.
• W2108918615 hasPrimaryLocation W21089186151 @default.
• W2108918615 hasRelatedWork W1967007247 @default.
• W2108918615 hasRelatedWork W1982469063 @default.
• W2108918615 hasRelatedWork W2024549821 @default.
• W2108918615 hasRelatedWork W2077890230 @default.
• W2108918615 hasRelatedWork W2165444693 @default.
• W2108918615 hasRelatedWork W2547447181 @default.
• W2108918615 hasRelatedWork W2793900350 @default.
• W2108918615 hasRelatedWork W4285042631 @default.
• W2108918615 hasRelatedWork W4308369983 @default.
• W2108918615 hasRelatedWork W4319940010 @default.
• W2108918615 hasVolume "286" @default.
• W2108918615 isParatext "false" @default.
• W2108918615 isRetracted "false" @default.
• W2108918615 magId "2108918615" @default.

• next