FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108940430> ?p ?o ?g. }

• W2108940430 endingPage "E1149" @default.
• W2108940430 startingPage "E1140" @default.
• W2108940430 abstract "Accumulating evidence suggests that alcohol, hepatitis C virus infection, steatosis with obesity, and insulin resistance are accompanied by iron overload states. Phlebotomy and oral iron chelators are effective treatments for these conditions and for hemochromatosis. However, the mechanisms by which iron depletion improves clinical factors remain unclear. We examined the effect of iron depletion in a model of type 2 diabetes, Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Age-matched Long-Evans Tokushima Otsuka (LETO) rats were used as controls for all experiments. Iron restriction was performed by eliminating iron in the diet from 15 wk of age or by phlebotomy. Phlebotomy was commenced at 29 wk of age by removing 4 and 3 ml of blood from the tail vein every week in OLETF and LETO rats, respectively. Rats were euthanized at 43 wk of age, and detailed analyses were performed. The plasma ferritin concentration was markedly higher in OLETF rats and decreased in iron-deficient (ID) diet and phlebotomy rats. Hemoglobin A(1c) (Hb A(1c)) was decreased significantly in OLETF rats fed the ID diet and in the phlebotomy group. Increased levels of triglycerides, glucose, free fatty acids, and total cholesterol were found in ID OLETF rats. Plasma, liver, and pancreas lipid peroxidation and hepatic superoxide production decreased in both groups. Pancreatic fibrosis and insulin levels improved in both groups of OLETF rats. Pancreatic levels of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands and hypoxia-inducible factor (HIF)-1alpha were decreased significantly in OLETF rats. These factors were normalized in both rats fed ID and phlebotomy groups of OLETF rats. In conclusion, iron depletion improved diabetic complications by inhibition of oxidative stress and TGFbeta signal pathways and the maintenance of pancreatic PPARbeta/delta and HIF-1alpha pathways." @default.
• W2108940430 created "2016-06-24" @default.
• W2108940430 creator A5017563166 @default.
• W2108940430 creator A5044771753 @default.
• W2108940430 creator A5050875751 @default.
• W2108940430 creator A5061869584 @default.
• W2108940430 creator A5067676082 @default.
• W2108940430 creator A5071589326 @default.
• W2108940430 creator A5077144151 @default.
• W2108940430 creator A5082589023 @default.
• W2108940430 creator A5083297952 @default.
• W2108940430 date "2010-06-01" @default.
• W2108940430 modified "2023-10-18" @default.
• W2108940430 title "Iron restriction improves type 2 diabetes mellitus in Otsuka Long-Evans Tokushima fatty rats" @default.
• W2108940430 cites W1966817853 @default.
• W2108940430 cites W1968703258 @default.
• W2108940430 cites W1969995774 @default.
• W2108940430 cites W1972089648 @default.
• W2108940430 cites W1975962309 @default.
• W2108940430 cites W1976910163 @default.
• W2108940430 cites W1982578021 @default.
• W2108940430 cites W2001591118 @default.
• W2108940430 cites W2013221678 @default.
• W2108940430 cites W2014259643 @default.
• W2108940430 cites W2020781643 @default.
• W2108940430 cites W2047982128 @default.
• W2108940430 cites W2062993566 @default.
• W2108940430 cites W2064064067 @default.
• W2108940430 cites W2070766163 @default.
• W2108940430 cites W2074417648 @default.
• W2108940430 cites W2079958052 @default.
• W2108940430 cites W2083051884 @default.
• W2108940430 cites W2091673549 @default.
• W2108940430 cites W2103116278 @default.
• W2108940430 cites W2122426315 @default.
• W2108940430 cites W2123149215 @default.
• W2108940430 cites W2128557965 @default.
• W2108940430 cites W2134670001 @default.
• W2108940430 cites W2134730662 @default.
• W2108940430 cites W2140892017 @default.
• W2108940430 cites W2146788074 @default.
• W2108940430 cites W2151807579 @default.
• W2108940430 cites W2151950872 @default.
• W2108940430 cites W2152102707 @default.
• W2108940430 cites W2165611171 @default.
• W2108940430 cites W2170075604 @default.
• W2108940430 cites W4236442175 @default.
• W2108940430 doi "https://doi.org/10.1152/ajpendo.00620.2009" @default.
• W2108940430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20215574" @default.
• W2108940430 hasPublicationYear "2010" @default.
• W2108940430 type Work @default.
• W2108940430 sameAs 2108940430 @default.
• W2108940430 citedByCount "82" @default.
• W2108940430 countsByYear W21089404302012 @default.
• W2108940430 countsByYear W21089404302013 @default.
• W2108940430 countsByYear W21089404302014 @default.
• W2108940430 countsByYear W21089404302015 @default.
• W2108940430 countsByYear W21089404302016 @default.
• W2108940430 countsByYear W21089404302017 @default.
• W2108940430 countsByYear W21089404302018 @default.
• W2108940430 countsByYear W21089404302019 @default.
• W2108940430 countsByYear W21089404302020 @default.
• W2108940430 countsByYear W21089404302021 @default.
• W2108940430 countsByYear W21089404302022 @default.
• W2108940430 countsByYear W21089404302023 @default.
• W2108940430 crossrefType "journal-article" @default.
• W2108940430 hasAuthorship W2108940430A5017563166 @default.
• W2108940430 hasAuthorship W2108940430A5044771753 @default.
• W2108940430 hasAuthorship W2108940430A5050875751 @default.
• W2108940430 hasAuthorship W2108940430A5061869584 @default.
• W2108940430 hasAuthorship W2108940430A5067676082 @default.
• W2108940430 hasAuthorship W2108940430A5071589326 @default.
• W2108940430 hasAuthorship W2108940430A5077144151 @default.
• W2108940430 hasAuthorship W2108940430A5082589023 @default.
• W2108940430 hasAuthorship W2108940430A5083297952 @default.
• W2108940430 hasConcept C126322002 @default.
• W2108940430 hasConcept C134018914 @default.
• W2108940430 hasConcept C185592680 @default.
• W2108940430 hasConcept C2776175330 @default.
• W2108940430 hasConcept C2777180221 @default.
• W2108940430 hasConcept C2777357209 @default.
• W2108940430 hasConcept C2777391703 @default.
• W2108940430 hasConcept C555293320 @default.
• W2108940430 hasConcept C71924100 @default.
• W2108940430 hasConceptScore W2108940430C126322002 @default.
• W2108940430 hasConceptScore W2108940430C134018914 @default.
• W2108940430 hasConceptScore W2108940430C185592680 @default.
• W2108940430 hasConceptScore W2108940430C2776175330 @default.
• W2108940430 hasConceptScore W2108940430C2777180221 @default.
• W2108940430 hasConceptScore W2108940430C2777357209 @default.
• W2108940430 hasConceptScore W2108940430C2777391703 @default.
• W2108940430 hasConceptScore W2108940430C555293320 @default.
• W2108940430 hasConceptScore W2108940430C71924100 @default.
• W2108940430 hasIssue "6" @default.
• W2108940430 hasLocation W21089404301 @default.
• W2108940430 hasLocation W21089404302 @default.
• W2108940430 hasOpenAccess W2108940430 @default.
• W2108940430 hasPrimaryLocation W21089404301 @default.

• next