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• W2108956559 abstract "In the general population the prevalence of peripheral arterial disease (PAD) varies between 7 and 21% [ 1 Fowkes F.G. Housley E. Cawood E.H. et al. Edinburgh Artery Study: prevalence of asymptomatic and symptomatic peripheral arterial disease in the general population. International Journal of Epidemiology. 1991; 20: 384-392 Crossref PubMed Scopus (966) Google Scholar , 2 Diehm C. Lange S. Darius H. et al. Association of low ankle brachial index with high mortality in primary care. European Heart Journal. 2006; 27: 1743-1749 Crossref PubMed Scopus (236) Google Scholar , 3 Alzamora M.T. Fores R. Baena-Diez J.M. et al. The peripheral arterial disease study (PERART/ARTPER): prevalence and risk factors in the general population. BMC Public Health. 2010; 10: 38 Crossref PubMed Scopus (115) Google Scholar ]. The prevalence is strongly related to age, gender and the definition of PAD, defined by the ankle-brachial index (ABI) cut-off and/or the presence of symptoms. Before progressing to clinical stages such as intermittent claudication or even critical limb ischemia, PAD is typically asymptomatic during several years [ [4] Rutherford R.B. Standards for evaluating results of interventional therapy for peripheral vascular disease. Circulation. 1991; 83: I6-11 PubMed Google Scholar ]. The ABI, as a screening tool, has emerged as an accurate and reliable marker of (a)symptomatic PAD and as a measure of systemic atherosclerotic burden. In the primary care setting, the getABI study demonstrated a prevalence of PAD of 18%, while only 2.8% of the patients were symptomatic [ [2] Diehm C. Lange S. Darius H. et al. Association of low ankle brachial index with high mortality in primary care. European Heart Journal. 2006; 27: 1743-1749 Crossref PubMed Scopus (236) Google Scholar ]. These data were confirmed in several other general population-based studies, revealing a high prevalence of asymptomatic PAD [ 3 Alzamora M.T. Fores R. Baena-Diez J.M. et al. The peripheral arterial disease study (PERART/ARTPER): prevalence and risk factors in the general population. BMC Public Health. 2010; 10: 38 Crossref PubMed Scopus (115) Google Scholar , 5 Ramos R. Quesada M. Solanas P. et al. Prevalence of symptomatic and asymptomatic peripheral arterial disease and the value of the ankle-brachial index to stratify cardiovascular risk. European Journal of Vascular and Endovascular Surgery. 2009; 38: 305-311 Abstract Full Text Full Text PDF PubMed Scopus (126) Google Scholar ]." @default.
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• W2108956559 title "Risk factors and peripheral arterial disease; a plea for objective measurements" @default.
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