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• W2108983064 abstract "Objective: PAI-1 Ag has been suggested as an independent risk factor for reproductive loss (SpAb) in some women. We sought to describe relationships among plasminogen activator inhibitor-1 levels, and prothrombin G20210A and MTHFR C677T gene polymorphisms, as a function of ovarian appearance on routine transvaginal ultrasound (TV-USG) in women presenting for infertility evaluation. Design: Prospective prevalence study. Materials and Methods: In 21 patients, TV-USG assessment of ovarian morphology yielded a score on a binary scale as either normal or polycystic. “Polycystic” ovaries showed ≥10 small (<10mm) peripheral cysts with central stromal sparing. Allele-specific PCR/restriction fragment length polymorphism (RFLP) analysis was performed via restriction endonuclease for both G20210A and C677T. Additionally, plasminogen activator inhibitor-1 antigen (PAI-1 Ag), PAI-1 activity, and t-PA Ag were measured by Scripps reference laboratory method. Mutation status (homozygous, heterozygous, or no mutation) was registered for all cases. Patients were screened prior to participation to identify any overt fibrinolytic diatheses. For this study, SpAb was defined as non-elective pregnancy loss at ≤20th gestational week. Results: Mean (IQR [25;75]) age was 30.2 [26;33]; BMI=30.9 [25;34]. Selected characteristics of the study group are summarized below: legendOvarian image (TV-USG)legendNotes: aa = homozygous, Aa = heterozygous, AA = no mutation., legend1 ng/ml., legend2 u/ml., legend3 By two sample t-test.SpAbPolymorphism statusMean (IQR[25;75]) titreG20210AC677TPAI-1 Ag1PAI-1 activity2t-PA Ag101≥2aaAaAAaaAaAANon-polycystic51100713312.7 [4.9;15.4]1.4 [0.3;1.7]4.0 [2.6;4.7]Polycystic10220014031136.6 [11.0;47.3]2.4 [0.7;3.2]5.2 [4.6;5.6]p30.0380.2610.155legend Notes: aa = homozygous, Aa = heterozygous, AA = no mutation.legend 1 ng/ml.legend 2 u/ml.legend 3 By two sample t-test. Open table in a new tab Conclusion: We found PAI-1 Ag titres significantly higher when “polycystic” ovarian morphology was present. PAI-1 activity and t-PA Ag levels were also elevated in this group, but this difference was not statistically significant. Overall prevalence of G20210A and C677T gene polymorphisms ranged from 0 to 28.6% in this sample. No important correlations among mutation status, SpAb history, and/or ovarian morphology were identified, although the study group lacked sufficient size to permit analysis of all parameters. Office assessment of ovarian morphology via transvaginal ultrasound appears to be a simple method to identify patients with elevated PAI-1 Ag, a reversible condition associated with thrombosis-induced placental insufficiency. Since PAI-1 testing relies on a tedious assay not universally available, clinical sonographic evaluation may permit targeted therapy to reduce reproductive loss among women with hypofibrinolytic tendencies." @default.
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• W2108983064 date "2000-09-01" @default.
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• W2108983064 title "Plasminogen Activator Inhibitor-1 Levels, Prothrombin G20210A and Methyltetrahydrofolate Reductase C677T Gene Polymorphism Frequencies, and Reproductive History: Correlations with Ultrasonographic Ovarian Morphology" @default.
• W2108983064 doi "https://doi.org/10.1016/s0015-0282(00)00760-3" @default.
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