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• W2108992945 abstract "We have used genetic and microarray analysis to determine how ionizing radiation (IR) induces p53-dependent transcription and apoptosis in Drosophila melanogaster. IR induces MNK/Chk2-dependent phosphorylation of p53 without changing p53 protein levels, indicating that p53 activity can be regulated without an Mdm2-like activity. In a genome-wide analysis of IR-induced transcription in wild-type and mutant embryos, all IR-induced increases in transcript levels required both p53 and the Drosophila Chk2 homolog MNK. Proapoptotic targets of p53 include hid, reaper, sickle, and the tumor necrosis factor family member Eiger. Overexpression of Eiger is sufficient to induce apoptosis, but mutations in Eiger do not block IR-induced apoptosis. Animals heterozygous for deletions that span the reaper, sickle, and hid genes exhibited reduced IR-dependent apoptosis, indicating that this gene complex is haploinsufficient for induction of apoptosis. Among the genes in this region, hid plays a central, dosage-sensitive role in IR-induced apoptosis. p53 and MNK/Chk2 also regulate DNA repair genes, including two components of the nonhomologous end-joining repair pathway, Ku70 and Ku80. Our results indicate that MNK/Chk2-dependent modification of Drosophila p53 activates a global transcriptional response to DNA damage that induces error-prone DNA repair as well as intrinsic and extrinsic apoptosis pathways." @default.
• W2108992945 created "2016-06-24" @default.
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• W2108992945 date "2004-02-01" @default.
• W2108992945 modified "2023-10-16" @default.
• W2108992945 title "<i>Drosophila melanogaster</i> MNK/Chk2 and p53 Regulate Multiple DNA Repair and Apoptotic Pathways following DNA Damage" @default.
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• W2108992945 cites W1507334568 @default.
• W2108992945 cites W1531240647 @default.
• W2108992945 cites W1534987406 @default.
• W2108992945 cites W1605970215 @default.
• W2108992945 cites W165254100 @default.
• W2108992945 cites W1963636909 @default.
• W2108992945 cites W1964269904 @default.
• W2108992945 cites W1964538721 @default.
• W2108992945 cites W1966343869 @default.
• W2108992945 cites W1968552183 @default.
• W2108992945 cites W1980176640 @default.
• W2108992945 cites W1984080722 @default.
• W2108992945 cites W1984755213 @default.
• W2108992945 cites W1984925149 @default.
• W2108992945 cites W1986179131 @default.
• W2108992945 cites W1990248374 @default.
• W2108992945 cites W1991982212 @default.
• W2108992945 cites W1996952871 @default.
• W2108992945 cites W1997054509 @default.
• W2108992945 cites W1998287298 @default.
• W2108992945 cites W2000823493 @default.
• W2108992945 cites W2003411878 @default.
• W2108992945 cites W2006705796 @default.
• W2108992945 cites W2023153839 @default.
• W2108992945 cites W2023331434 @default.
• W2108992945 cites W2023420554 @default.
• W2108992945 cites W2027920612 @default.
• W2108992945 cites W2028044172 @default.
• W2108992945 cites W2038437697 @default.
• W2108992945 cites W2041629876 @default.
• W2108992945 cites W2043107604 @default.
• W2108992945 cites W2046930479 @default.
• W2108992945 cites W2048109276 @default.
• W2108992945 cites W2049422138 @default.
• W2108992945 cites W2055580039 @default.
• W2108992945 cites W2056518099 @default.
• W2108992945 cites W2063669247 @default.
• W2108992945 cites W2067087347 @default.
• W2108992945 cites W2070019711 @default.
• W2108992945 cites W2078144681 @default.
• W2108992945 cites W2080602376 @default.
• W2108992945 cites W2080993588 @default.
• W2108992945 cites W2090538417 @default.
• W2108992945 cites W2092537625 @default.
• W2108992945 cites W2093655143 @default.
• W2108992945 cites W2096359570 @default.
• W2108992945 cites W2102566010 @default.
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• W2108992945 cites W2111131079 @default.
• W2108992945 cites W2112881364 @default.
• W2108992945 cites W2115345669 @default.
• W2108992945 cites W2118616529 @default.
• W2108992945 cites W2119506861 @default.
• W2108992945 cites W2124052729 @default.
• W2108992945 cites W2124553555 @default.
• W2108992945 cites W2128252882 @default.
• W2108992945 cites W2130883309 @default.
• W2108992945 cites W2131833681 @default.
• W2108992945 cites W2136545880 @default.
• W2108992945 cites W2139135963 @default.
• W2108992945 cites W2148207751 @default.
• W2108992945 cites W2149442287 @default.
• W2108992945 cites W2155640249 @default.
• W2108992945 cites W2155995453 @default.
• W2108992945 cites W2162735386 @default.
• W2108992945 cites W2163668204 @default.
• W2108992945 cites W2166451270 @default.
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• W2108992945 cites W2334697789 @default.
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• W2108992945 doi "https://doi.org/10.1128/mcb.24.3.1219-1231.2004" @default.
• W2108992945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/321428" @default.
• W2108992945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14729967" @default.
• W2108992945 hasPublicationYear "2004" @default.
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