Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108993318> ?p ?o ?g. }
- W2108993318 endingPage "511" @default.
- W2108993318 startingPage "503" @default.
- W2108993318 abstract "Human embryonic stem (hES) cells are pluripotent cells usually derived from the inner cell mass (ICM) of blastocysts. Because of their ability to differentiate into all three embryonic germ layers, hES cells represent an important material for studying developmental biology and cell replacement therapy. hES cell lines derived from blastocysts diagnosed as carrying a genetic disorder after PGD represent in vitro disease models.ICMs isolated by immunosurgery from human blastocysts donated for research after IVF cycles and after PGD were plated in serum-free medium (except VUB01) on mouse feeder layers.Five hES cell lines were isolated, two from IVF embryos and three from PGD embryos. All lines behave similarly in culture and present a normal karyotype. The lines express all the markers considered characteristic of undifferentiated hES cells and were proven to be pluripotent both in vitro and in vivo (ongoing for VUB05_HD).We report here on the derivation of two hES cell lines presumed to be genetically normal (VUB01 and VUB02) and three hES cell lines carrying mutations for myotonic dystrophy type 1 (VUB03_DM1), cystic fibrosis (VUB04_CF) and Huntington disease (VUB05_HD)." @default.
- W2108993318 created "2016-06-24" @default.
- W2108993318 creator A5012839649 @default.
- W2108993318 creator A5014427312 @default.
- W2108993318 creator A5038307696 @default.
- W2108993318 creator A5051965991 @default.
- W2108993318 creator A5055004236 @default.
- W2108993318 creator A5056960441 @default.
- W2108993318 creator A5061166680 @default.
- W2108993318 creator A5061240995 @default.
- W2108993318 creator A5061394784 @default.
- W2108993318 creator A5072634770 @default.
- W2108993318 creator A5078295738 @default.
- W2108993318 date "2005-11-10" @default.
- W2108993318 modified "2023-09-30" @default.
- W2108993318 title "Derivation of human embryonic stem cell lines from embryos obtained after IVF and after PGD for monogenic disorders" @default.
- W2108993318 cites W1536742213 @default.
- W2108993318 cites W1571607447 @default.
- W2108993318 cites W1603508604 @default.
- W2108993318 cites W1922169195 @default.
- W2108993318 cites W1970834330 @default.
- W2108993318 cites W1979970002 @default.
- W2108993318 cites W1988865085 @default.
- W2108993318 cites W1992609622 @default.
- W2108993318 cites W2030895549 @default.
- W2108993318 cites W2032897530 @default.
- W2108993318 cites W2042047814 @default.
- W2108993318 cites W2047107520 @default.
- W2108993318 cites W2066589250 @default.
- W2108993318 cites W2072254270 @default.
- W2108993318 cites W2073880868 @default.
- W2108993318 cites W2081804379 @default.
- W2108993318 cites W2086943348 @default.
- W2108993318 cites W2087693815 @default.
- W2108993318 cites W2091996572 @default.
- W2108993318 cites W2097679827 @default.
- W2108993318 cites W2098785511 @default.
- W2108993318 cites W2104089107 @default.
- W2108993318 cites W2123999433 @default.
- W2108993318 cites W2136340785 @default.
- W2108993318 cites W2138442302 @default.
- W2108993318 cites W2142001424 @default.
- W2108993318 cites W2149523673 @default.
- W2108993318 cites W2152305065 @default.
- W2108993318 cites W2163236108 @default.
- W2108993318 cites W2164899730 @default.
- W2108993318 cites W4247315162 @default.
- W2108993318 doi "https://doi.org/10.1093/humrep/dei345" @default.
- W2108993318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16284066" @default.
- W2108993318 hasPublicationYear "2005" @default.
- W2108993318 type Work @default.
- W2108993318 sameAs 2108993318 @default.
- W2108993318 citedByCount "224" @default.
- W2108993318 countsByYear W21089933182012 @default.
- W2108993318 countsByYear W21089933182013 @default.
- W2108993318 countsByYear W21089933182014 @default.
- W2108993318 countsByYear W21089933182015 @default.
- W2108993318 countsByYear W21089933182016 @default.
- W2108993318 countsByYear W21089933182017 @default.
- W2108993318 countsByYear W21089933182018 @default.
- W2108993318 countsByYear W21089933182019 @default.
- W2108993318 countsByYear W21089933182020 @default.
- W2108993318 countsByYear W21089933182021 @default.
- W2108993318 countsByYear W21089933182022 @default.
- W2108993318 countsByYear W21089933182023 @default.
- W2108993318 crossrefType "journal-article" @default.
- W2108993318 hasAuthorship W2108993318A5012839649 @default.
- W2108993318 hasAuthorship W2108993318A5014427312 @default.
- W2108993318 hasAuthorship W2108993318A5038307696 @default.
- W2108993318 hasAuthorship W2108993318A5051965991 @default.
- W2108993318 hasAuthorship W2108993318A5055004236 @default.
- W2108993318 hasAuthorship W2108993318A5056960441 @default.
- W2108993318 hasAuthorship W2108993318A5061166680 @default.
- W2108993318 hasAuthorship W2108993318A5061240995 @default.
- W2108993318 hasAuthorship W2108993318A5061394784 @default.
- W2108993318 hasAuthorship W2108993318A5072634770 @default.
- W2108993318 hasAuthorship W2108993318A5078295738 @default.
- W2108993318 hasBestOaLocation W21089933181 @default.
- W2108993318 hasConcept C104317684 @default.
- W2108993318 hasConcept C107459253 @default.
- W2108993318 hasConcept C145103041 @default.
- W2108993318 hasConcept C159399396 @default.
- W2108993318 hasConcept C16685009 @default.
- W2108993318 hasConcept C196843134 @default.
- W2108993318 hasConcept C203014093 @default.
- W2108993318 hasConcept C23416140 @default.
- W2108993318 hasConcept C2778063965 @default.
- W2108993318 hasConcept C2778177303 @default.
- W2108993318 hasConcept C28328180 @default.
- W2108993318 hasConcept C30481170 @default.
- W2108993318 hasConcept C53226629 @default.
- W2108993318 hasConcept C54355233 @default.
- W2108993318 hasConcept C71924100 @default.
- W2108993318 hasConcept C81885089 @default.
- W2108993318 hasConcept C86803240 @default.
- W2108993318 hasConcept C87073359 @default.
- W2108993318 hasConcept C95444343 @default.
- W2108993318 hasConceptScore W2108993318C104317684 @default.