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• W2108997669 abstract "An enzyme that catalyzes the formose reaction, termed formolase, was recently engineered through a combination of computational protein design and directed evolution. We have investigated the kinetic role of the computationally designed residues and further characterized the enzyme's product profile. Kinetic studies illustrated that the computationally designed mutations were synergistic in their contributions towards enhancing activity. Mass spectrometry revealed that the engineered enzyme produces two products of the formose reaction-dihydroxyacetone and glycolaldehyde-with the product profile dependent on the formaldehyde concentration. We further explored the effects of this product profile on the thermodynamics and yield of the overall carbon assimilation from the formolase pathway to help guide future efforts to engineer this pathway." @default.
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• W2108997669 date "2015-07-27" @default.
• W2108997669 modified "2023-10-14" @default.
• W2108997669 title "Mechanistic Analysis of an Engineered Enzyme that Catalyzes the Formose Reaction" @default.
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• W2108997669 doi "https://doi.org/10.1002/cbic.201500228" @default.
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