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• W2109002955 abstract "Obesity is associated with higher 4E-BP1 expression in endometrial cancer Emily Falk Libby,1,* Maria Azrad,1,* Lea Novak,2 Ana I Vazquez,3 Tamara R Wilson,1 Wendy Demark-Wahnefried1 1Department of Nutrition Sciences, 2Department of Pathology, 3Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA*These authors contributed equally to this workPurpose: Obesity is associated with risk and prognosis of endometrial cancer (EC), and the mammalian target of rapamycin complex 1 (mTORC1) pathway may play an instrumental role. We sought to explore the associations between cellular proliferation, Akt, and 4E binding protein-1 (4E-BP1) (a downstream target of mTORC1), in obese and nonobese women with and without EC.Methods: Archival tissue-specimens from endometrial biopsies were grouped into two broad categories based on the observed disease behavior and similarities in tissue staining patterns: benign/hyperplasia (without cytologic atypia) (n=18) versus atypia (complex hyperplasia with cytologic atypia)/carcinoma (n=25). The characteristics of the study population, including height and weight to determine body mass index (BMI: kg/m2), were abstracted from medical records. Immunohistochemistry was used to assess the phosphorylated (p)Akt, p4E-BP1, and antigen Ki67.Results: Cytoplasmic and nuclear pAkt were significantly associated with cytoplasmic p4E-BP1 (ρ=+0.48, ρ=+0.50) (P" @default.
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• W2109002955 date "2014-01-01" @default.
• W2109002955 modified "2023-09-25" @default.
• W2109002955 title "Obesity is associated with higher 4E-BP1 expression in endometrial cancer" @default.
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• W2109002955 doi "https://doi.org/10.2147/cbf.s53530" @default.
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