FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109013581> ?p ?o ?g. }

• W2109013581 endingPage "1933" @default.
• W2109013581 startingPage "1929" @default.
• W2109013581 abstract "Abstract Increases in fetal hemoglobin have been identified after birth in several clinical settings associated with stressed or malignant erythropoiesis. To better understand the relationship between the expression of this fetal protein and growth, donated human erythroid progenitor cells were cultured in the presence of erythropoietin (EPO) plus the growth-modifying cytokine stem cell factor (SCF), and several growth-related signaling pathways were interrogated. Only the MEK1/2 inhibitor (PD98059) demonstrated significant effects on fetal hemoglobin. In the absence of PD98059, levels of fetal hemoglobin averaged 27.4% ± 7.9% in EPO+SCF compared with 1.26% ± 1.7% in EPO alone (P = .02). A linear dose response in levels of fetal hemoglobin to PD98059 was detected (0.16 μM = 27.13%, 0.8 μM = 19.6%, 4 μM = 12.2%, 20 μM = 1.54%). Western blot analyses revealed that SCF was required for phosphorylation of MEK and p44MAPK in this setting, and quantitative polymerase chain reaction demonstrated a significant increase in γ-globin mRNA. Particular perturbations of growth-related signaling may also function to activate tissue-specific genes normally expressed during fetal development. This concept may be relevant for the development of new treatment rationales for beta hemoglobinopathies." @default.
• W2109013581 created "2016-06-24" @default.
• W2109013581 creator A5032746542 @default.
• W2109013581 creator A5052306699 @default.
• W2109013581 creator A5055255923 @default.
• W2109013581 creator A5056020457 @default.
• W2109013581 date "2004-03-01" @default.
• W2109013581 modified "2023-10-15" @default.
• W2109013581 title "A signaling mechanism for growth-related expression of fetal hemoglobin" @default.
• W2109013581 cites W1538978269 @default.
• W2109013581 cites W1546164714 @default.
• W2109013581 cites W1561219581 @default.
• W2109013581 cites W1575784571 @default.
• W2109013581 cites W1624442503 @default.
• W2109013581 cites W172498270 @default.
• W2109013581 cites W1972735584 @default.
• W2109013581 cites W1973929883 @default.
• W2109013581 cites W1974376373 @default.
• W2109013581 cites W1984362855 @default.
• W2109013581 cites W1990566663 @default.
• W2109013581 cites W1997656209 @default.
• W2109013581 cites W2004289105 @default.
• W2109013581 cites W2011030679 @default.
• W2109013581 cites W2015794428 @default.
• W2109013581 cites W2035936653 @default.
• W2109013581 cites W2053510126 @default.
• W2109013581 cites W2061188498 @default.
• W2109013581 cites W2076153728 @default.
• W2109013581 cites W2076741524 @default.
• W2109013581 cites W2086819383 @default.
• W2109013581 cites W2090482255 @default.
• W2109013581 cites W2106119346 @default.
• W2109013581 cites W2108041597 @default.
• W2109013581 cites W2132755748 @default.
• W2109013581 cites W2156597055 @default.
• W2109013581 cites W2171702968 @default.
• W2109013581 cites W2331369924 @default.
• W2109013581 cites W2409082022 @default.
• W2109013581 cites W2413702326 @default.
• W2109013581 cites W2792659630 @default.
• W2109013581 cites W283362244 @default.
• W2109013581 cites W4233402941 @default.
• W2109013581 cites W4249969224 @default.
• W2109013581 cites W69347198 @default.
• W2109013581 cites W2331322280 @default.
• W2109013581 doi "https://doi.org/10.1182/blood-2003-05-1624" @default.
• W2109013581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14592835" @default.
• W2109013581 hasPublicationYear "2004" @default.
• W2109013581 type Work @default.
• W2109013581 sameAs 2109013581 @default.
• W2109013581 citedByCount "35" @default.
• W2109013581 countsByYear W21090135812012 @default.
• W2109013581 countsByYear W21090135812013 @default.
• W2109013581 countsByYear W21090135812014 @default.
• W2109013581 countsByYear W21090135812015 @default.
• W2109013581 countsByYear W21090135812017 @default.
• W2109013581 countsByYear W21090135812022 @default.
• W2109013581 crossrefType "journal-article" @default.
• W2109013581 hasAuthorship W2109013581A5032746542 @default.
• W2109013581 hasAuthorship W2109013581A5052306699 @default.
• W2109013581 hasAuthorship W2109013581A5055255923 @default.
• W2109013581 hasAuthorship W2109013581A5056020457 @default.
• W2109013581 hasBestOaLocation W21090135811 @default.
• W2109013581 hasConcept C125996951 @default.
• W2109013581 hasConcept C126322002 @default.
• W2109013581 hasConcept C134018914 @default.
• W2109013581 hasConcept C16685009 @default.
• W2109013581 hasConcept C172680121 @default.
• W2109013581 hasConcept C201750760 @default.
• W2109013581 hasConcept C2022786 @default.
• W2109013581 hasConcept C2776317666 @default.
• W2109013581 hasConcept C2778248108 @default.
• W2109013581 hasConcept C2778534260 @default.
• W2109013581 hasConcept C2778917026 @default.
• W2109013581 hasConcept C2779234561 @default.
• W2109013581 hasConcept C2779703530 @default.
• W2109013581 hasConcept C28328180 @default.
• W2109013581 hasConcept C54355233 @default.
• W2109013581 hasConcept C55493867 @default.
• W2109013581 hasConcept C62112901 @default.
• W2109013581 hasConcept C62478195 @default.
• W2109013581 hasConcept C71924100 @default.
• W2109013581 hasConcept C86803240 @default.
• W2109013581 hasConcept C95444343 @default.
• W2109013581 hasConceptScore W2109013581C125996951 @default.
• W2109013581 hasConceptScore W2109013581C126322002 @default.
• W2109013581 hasConceptScore W2109013581C134018914 @default.
• W2109013581 hasConceptScore W2109013581C16685009 @default.
• W2109013581 hasConceptScore W2109013581C172680121 @default.
• W2109013581 hasConceptScore W2109013581C201750760 @default.
• W2109013581 hasConceptScore W2109013581C2022786 @default.
• W2109013581 hasConceptScore W2109013581C2776317666 @default.
• W2109013581 hasConceptScore W2109013581C2778248108 @default.
• W2109013581 hasConceptScore W2109013581C2778534260 @default.
• W2109013581 hasConceptScore W2109013581C2778917026 @default.
• W2109013581 hasConceptScore W2109013581C2779234561 @default.
• W2109013581 hasConceptScore W2109013581C2779703530 @default.
• W2109013581 hasConceptScore W2109013581C28328180 @default.

• next