FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109014734> ?p ?o ?g. }

• W2109014734 endingPage "32" @default.
• W2109014734 startingPage "125" @default.
• W2109014734 abstract "The vasoconstrictors norepinephrine (NE) and angiotensin II (AII) mediate increases in oxygen uptake (VO2) by the constant flow perfused rat hind limb that are inhibited by quinidine-like membrane-stabilizing effects (involving the interruption of action potential) of (+/-)-propranolol with little effect on vasoconstriction. The membrane labilizer veratridine, 10 microM, which has the capability of maintaining voltage-gated Na+ channels of the plasma membrane in their open state, also increases VO2 but without an increase in pressure. Thus in the present study veratridine was characterized in detail and compared with NE in the same system. Veratridine (3-100 microM) produced a dose-dependent stimulation of VO2 (from 11.8 +/- 0.3 to 20.4 +/- 0.6 mumol.h-1.g-1 (n = 5), p < 0.0001) and lactate efflux (LE) (from 7.4 +/- 0.6 to 23.0 +/- 4.7 mumol.h-1.g-1 (n = 5), p < 0.01). These increases were independent of vasoconstriction at low doses (< or = 10 microM). At higher doses of veratridine the accompanying minor vasoconstriction (from 17 +/- 1 to 30 +/- 2 mmHg (1 mmHg = 133.3 Pa) (n = 5), p < 0.005) was blocked by sodium nitroprusside (NP) while neither VO2 nor LE was greatly affected. Low Na+ perfusions (25 mM) did not affect the vasoconstrictor action of NE but markedly inhibited increases in VO2 and LE due to either veratridine or NE. Veratridine (10 microM) mediated increases in VO2 and LE were blocked by either (+/-)-propranolol (100 microM) or 150 microM quinidine. It is concluded that vasoconstrictors such as NE, which stimulate VO2 in the perfused rat hind limb, do so by a two-stage process involving an essential nitroprusside-sensitive redirection of flow followed by a mechanism involving increased ion movement across skeletal muscle cell membranes, which is blocked by membrane stabilizers. Veratridine achieves a similar increase in VO2 but may do so by directly destabilizing the skeletal muscle cell membrane without the requirement of a redirection of flow." @default.
• W2109014734 created "2016-06-24" @default.
• W2109014734 creator A5032479781 @default.
• W2109014734 creator A5033285682 @default.
• W2109014734 creator A5090861601 @default.
• W2109014734 date "1998-02-01" @default.
• W2109014734 modified "2023-09-23" @default.
• W2109014734 title "Similarities between vasoconstrictor- and veratridine-stimulated metabolism in perfused rat hind limb." @default.
• W2109014734 cites W179599991 @default.
• W2109014734 cites W1836747283 @default.
• W2109014734 cites W1874250917 @default.
• W2109014734 cites W1966170280 @default.
• W2109014734 cites W1982508692 @default.
• W2109014734 cites W1989662878 @default.
• W2109014734 cites W1991860010 @default.
• W2109014734 cites W1994103891 @default.
• W2109014734 cites W1994881845 @default.
• W2109014734 cites W1995770845 @default.
• W2109014734 cites W1999011050 @default.
• W2109014734 cites W1999323265 @default.
• W2109014734 cites W2017216254 @default.
• W2109014734 cites W2020024927 @default.
• W2109014734 cites W2020056957 @default.
• W2109014734 cites W2032692023 @default.
• W2109014734 cites W2034084412 @default.
• W2109014734 cites W2043063294 @default.
• W2109014734 cites W2046970032 @default.
• W2109014734 cites W2056135625 @default.
• W2109014734 cites W2084260408 @default.
• W2109014734 cites W2093271206 @default.
• W2109014734 cites W2094362927 @default.
• W2109014734 cites W2102397442 @default.
• W2109014734 cites W2122601554 @default.
• W2109014734 cites W2200292682 @default.
• W2109014734 cites W2248848514 @default.
• W2109014734 cites W2270816426 @default.
• W2109014734 cites W2277369219 @default.
• W2109014734 cites W2419362575 @default.
• W2109014734 cites W2464815531 @default.
• W2109014734 cites W623570351 @default.
• W2109014734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9635150" @default.
• W2109014734 hasPublicationYear "1998" @default.
• W2109014734 type Work @default.
• W2109014734 sameAs 2109014734 @default.
• W2109014734 citedByCount "2" @default.
• W2109014734 crossrefType "journal-article" @default.
• W2109014734 hasAuthorship W2109014734A5032479781 @default.
• W2109014734 hasAuthorship W2109014734A5033285682 @default.
• W2109014734 hasAuthorship W2109014734A5090861601 @default.
• W2109014734 hasConcept C126322002 @default.
• W2109014734 hasConcept C134018914 @default.
• W2109014734 hasConcept C170493617 @default.
• W2109014734 hasConcept C178790620 @default.
• W2109014734 hasConcept C185592680 @default.
• W2109014734 hasConcept C2776986425 @default.
• W2109014734 hasConcept C2778151854 @default.
• W2109014734 hasConcept C2779610285 @default.
• W2109014734 hasConcept C2779961880 @default.
• W2109014734 hasConcept C2780339425 @default.
• W2109014734 hasConcept C2908929049 @default.
• W2109014734 hasConcept C50952357 @default.
• W2109014734 hasConcept C519581460 @default.
• W2109014734 hasConcept C537181965 @default.
• W2109014734 hasConcept C55493867 @default.
• W2109014734 hasConcept C71924100 @default.
• W2109014734 hasConcept C86803240 @default.
• W2109014734 hasConceptScore W2109014734C126322002 @default.
• W2109014734 hasConceptScore W2109014734C134018914 @default.
• W2109014734 hasConceptScore W2109014734C170493617 @default.
• W2109014734 hasConceptScore W2109014734C178790620 @default.
• W2109014734 hasConceptScore W2109014734C185592680 @default.
• W2109014734 hasConceptScore W2109014734C2776986425 @default.
• W2109014734 hasConceptScore W2109014734C2778151854 @default.
• W2109014734 hasConceptScore W2109014734C2779610285 @default.
• W2109014734 hasConceptScore W2109014734C2779961880 @default.
• W2109014734 hasConceptScore W2109014734C2780339425 @default.
• W2109014734 hasConceptScore W2109014734C2908929049 @default.
• W2109014734 hasConceptScore W2109014734C50952357 @default.
• W2109014734 hasConceptScore W2109014734C519581460 @default.
• W2109014734 hasConceptScore W2109014734C537181965 @default.
• W2109014734 hasConceptScore W2109014734C55493867 @default.
• W2109014734 hasConceptScore W2109014734C71924100 @default.
• W2109014734 hasConceptScore W2109014734C86803240 @default.
• W2109014734 hasIssue "2" @default.
• W2109014734 hasLocation W21090147341 @default.
• W2109014734 hasOpenAccess W2109014734 @default.
• W2109014734 hasPrimaryLocation W21090147341 @default.
• W2109014734 hasRelatedWork W1964591718 @default.
• W2109014734 hasRelatedWork W1980743080 @default.
• W2109014734 hasRelatedWork W1982806284 @default.
• W2109014734 hasRelatedWork W1988623063 @default.
• W2109014734 hasRelatedWork W2109014734 @default.
• W2109014734 hasRelatedWork W2141504910 @default.
• W2109014734 hasRelatedWork W2164260658 @default.
• W2109014734 hasRelatedWork W2404186823 @default.
• W2109014734 hasRelatedWork W4252613708 @default.
• W2109014734 hasRelatedWork W1993656166 @default.
• W2109014734 hasVolume "76" @default.

• next