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- W2109019498 abstract "The effects of N-hydroxyphenacetin on DNA function and structure were investigated to elucidate the involvement of phenacetin in analgesic nephropathy and transitional cell carcinoma. N-Hydroxyphenacetin or a metabolite inhibited synthesis of DNA, RNA and protein; DNA inhibition was greater at higher pH. No single-strand breaks were detectable in DNA after N-hydroxyphenacetin treatment and no appreciable effect on cell viability was observed at concentrations up to 5 mM. N-Hydroxyphenacetin-induced alteration to chromatin structure was detected using nucleoid sedimentation analysis. Direct binding to plasmid DNA was not observed. These observations are consistent with a role for phenacetin metabolites in renal disease." @default.
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- W2109019498 date "1987-01-01" @default.
- W2109019498 modified "2023-09-26" @default.
- W2109019498 title "Inhibition of DNA, RNA and protein synthesis and chromatin alteration byN-hydroxyphenacetin" @default.
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- W2109019498 doi "https://doi.org/10.3109/00498258709047181" @default.
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