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- W2109034092 endingPage "433" @default.
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- W2109034092 abstract "Vitamin D and calcium are essential for normal skeletal growth and for maintaining the mechanical and structural integrity of the skeleton. Reduced intake of calcium and vitamin D may be associated with reduced bone mass and osteoporosis while a chronic and severe vitamin D deficiency may lead to osteomalacia. Given the importance of vitamin D in bone homeostasis, common polymorphisms in the vitamin D receptor gene were the first to be investigated as possible determinants of bone mass and fracture risk. Even though results are still conflicting and the molecular mechanisms by which these polymorphisms influence receptor activity remain in part to be investigated, an additional important issue is represented by their potential pharmacogenomic and pharmacogenetic implications. This review analyzes major pharmacogenetic studies of polymorphisms in the vitamin D receptor gene and osteoporosis." @default.
- W2109034092 created "2016-06-24" @default.
- W2109034092 creator A5013534702 @default.
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- W2109034092 creator A5048078483 @default.
- W2109034092 creator A5052576992 @default.
- W2109034092 creator A5081666999 @default.
- W2109034092 date "2009-03-01" @default.
- W2109034092 modified "2023-10-12" @default.
- W2109034092 title "Update on the pharmacogenetics of the vitamin D receptor and osteoporosis" @default.
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