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• W2109045032 abstract "Rho kinase is involved in the pathogenesis of hypertension, which favors the occurrence of endothelium-dependent contractions. The present study was designed to determine the effects of two Rho kinase inhibitors, HA1077 [1-(5-isoquinolinesulfonyl)-homopiperazine (fasudil)] and Y27632 [(+)-(<i>R</i>)-<i>trans</i>-4-(1-aminoethyl)-<i>N</i>-(4-pyridyl) cyclohexane carboxamide dihydrochloride], on endothelium-dependent and -independent contractions. Isometric tension of 1-year-old spontaneously hypertensive rat and Wistar Kyoto aortae were measured. In the presence of <i>N</i>^ω-nitro-l-arginine methyl ester, HA1077, and Y27632 reduced endothelium-dependent contractions caused by acetylcholine and the calcium ionophore 5-(methylamino)-2-[[2<i>R</i>,3<i>R</i>,6<i>S</i>,8<i>S</i>,9<i>R</i>,11<i>R</i>)-3,9,11-trimethyl-8-[(1<i>S</i>)-1-methyl-2-oxo-2-(1<i>H</i>-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid (A23187). The Rho kinase inhibitors did not significantly affect prostacyclin production measured as 6-keto prostaglandin F_1α. They nearly abolished endothelium-independent contractions to (5<i>Z</i>)-7-[(1<i>R</i>,4<i>S</i>,5<i>S</i>,6<i>R</i>)-6-[(1<i>E</i>,3<i>S</i>)-3-hydroxy-1-octenyl]-2-oxabicyclo-[2.2.1]hept-5-yl]-5-heptenoic acid (U46619), prostaglandin F_2α, and phenylephrine. Western blotting revealed a comparable expression of Rho kinase in the aortae of the two strains. The reduction by Rho kinase inhibitors of endothelium-dependent contractions is mainly because of their direct effect on the vascular smooth muscle cells." @default.
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• W2109045032 date "2009-02-04" @default.
• W2109045032 modified "2023-10-03" @default.
• W2109045032 title "Rho Kinase Inhibitors Prevent Endothelium-Dependent Contractions in the Rat Aorta" @default.
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• W2109045032 doi "https://doi.org/10.1124/jpet.108.148247" @default.
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