FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109049969> ?p ?o ?g. }

• W2109049969 endingPage "98" @default.
• W2109049969 startingPage "92" @default.
• W2109049969 abstract "Agonists of G protein-coupled receptors, such as thrombin, act in part by transactivating the epidermal growth factor (EGF) receptor (EGFR). Although at first a ligand-independent mechanism for EGFR transactivation was postulated, it has recently been shown that this transactivation by various G protein-coupled receptor agonists can involve heparin-binding EGF-like growth factor (HB-EGF). Because thrombin stimulation of vascular smooth muscle cell migration is blocked by heparin and because heparin can displace HB-EGF, we investigated the possibility that thrombin stimulation of smooth muscle cells (SMCs) depends on EGFR activation by HB-EGF. In rat SMCs, EGFR phosphorylation and extracellular signal-regulated kinase (ERK) activation in response to thrombin are inhibited not only by the EGFR inhibitor AG1478 and by EGFR blocking antibody but also by heparin and by neutralizing HB-EGF antibody. HB-EGF-dependent signaling induced by thrombin is inhibited by batimastat, which suggests a requirement for pro-HB-EGF shedding by a metalloproteinase. We further demonstrate that this novel pathway is required for the migration of rat and baboon SMCs in response to thrombin. We conclude from these data that the inhibitory effect of heparin on SMC migration induced by thrombin relies, at least in part, on a blockade of HB-EGF-mediated EGFR transactivation." @default.
• W2109049969 created "2016-06-24" @default.
• W2109049969 creator A5008688662 @default.
• W2109049969 creator A5011331485 @default.
• W2109049969 creator A5039045480 @default.
• W2109049969 creator A5064950593 @default.
• W2109049969 creator A5077552332 @default.
• W2109049969 date "2000-07-21" @default.
• W2109049969 modified "2023-10-11" @default.
• W2109049969 title "Heparin Blockade of Thrombin-Induced Smooth Muscle Cell Migration Involves Inhibition of Epidermal Growth Factor (EGF) Receptor Transactivation by Heparin-Binding EGF-Like Growth Factor" @default.
• W2109049969 cites W1507735847 @default.
• W2109049969 cites W1774746154 @default.
• W2109049969 cites W1964499190 @default.
• W2109049969 cites W1974813965 @default.
• W2109049969 cites W1977798903 @default.
• W2109049969 cites W1980981080 @default.
• W2109049969 cites W1981493299 @default.
• W2109049969 cites W1993223505 @default.
• W2109049969 cites W2012104993 @default.
• W2109049969 cites W2012441637 @default.
• W2109049969 cites W2017751932 @default.
• W2109049969 cites W2022142677 @default.
• W2109049969 cites W2028534260 @default.
• W2109049969 cites W2029486437 @default.
• W2109049969 cites W2030377215 @default.
• W2109049969 cites W2041294148 @default.
• W2109049969 cites W2043526402 @default.
• W2109049969 cites W2055622229 @default.
• W2109049969 cites W2058742965 @default.
• W2109049969 cites W2072987324 @default.
• W2109049969 cites W2081210866 @default.
• W2109049969 cites W2084339088 @default.
• W2109049969 cites W2084805930 @default.
• W2109049969 cites W2101413460 @default.
• W2109049969 cites W2101846726 @default.
• W2109049969 cites W2123190981 @default.
• W2109049969 cites W2132475459 @default.
• W2109049969 cites W2137570167 @default.
• W2109049969 cites W2149419925 @default.
• W2109049969 cites W2153899018 @default.
• W2109049969 cites W2162827558 @default.
• W2109049969 cites W4232995978 @default.
• W2109049969 doi "https://doi.org/10.1161/01.res.87.2.92" @default.
• W2109049969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10903991" @default.
• W2109049969 hasPublicationYear "2000" @default.
• W2109049969 type Work @default.
• W2109049969 sameAs 2109049969 @default.
• W2109049969 citedByCount "155" @default.
• W2109049969 countsByYear W21090499692012 @default.
• W2109049969 countsByYear W21090499692013 @default.
• W2109049969 countsByYear W21090499692014 @default.
• W2109049969 countsByYear W21090499692015 @default.
• W2109049969 countsByYear W21090499692016 @default.
• W2109049969 countsByYear W21090499692017 @default.
• W2109049969 countsByYear W21090499692018 @default.
• W2109049969 countsByYear W21090499692019 @default.
• W2109049969 countsByYear W21090499692020 @default.
• W2109049969 countsByYear W21090499692021 @default.
• W2109049969 countsByYear W21090499692022 @default.
• W2109049969 countsByYear W21090499692023 @default.
• W2109049969 crossrefType "journal-article" @default.
• W2109049969 hasAuthorship W2109049969A5008688662 @default.
• W2109049969 hasAuthorship W2109049969A5011331485 @default.
• W2109049969 hasAuthorship W2109049969A5039045480 @default.
• W2109049969 hasAuthorship W2109049969A5064950593 @default.
• W2109049969 hasAuthorship W2109049969A5077552332 @default.
• W2109049969 hasBestOaLocation W21090499691 @default.
• W2109049969 hasConcept C104317684 @default.
• W2109049969 hasConcept C1292079 @default.
• W2109049969 hasConcept C153911025 @default.
• W2109049969 hasConcept C159048773 @default.
• W2109049969 hasConcept C170493617 @default.
• W2109049969 hasConcept C185592680 @default.
• W2109049969 hasConcept C203014093 @default.
• W2109049969 hasConcept C2775960820 @default.
• W2109049969 hasConcept C2776362946 @default.
• W2109049969 hasConcept C2777292125 @default.
• W2109049969 hasConcept C2777557582 @default.
• W2109049969 hasConcept C2778886182 @default.
• W2109049969 hasConcept C2779438470 @default.
• W2109049969 hasConcept C502942594 @default.
• W2109049969 hasConcept C55493867 @default.
• W2109049969 hasConcept C86339819 @default.
• W2109049969 hasConcept C86803240 @default.
• W2109049969 hasConcept C89560881 @default.
• W2109049969 hasConcept C95444343 @default.
• W2109049969 hasConceptScore W2109049969C104317684 @default.
• W2109049969 hasConceptScore W2109049969C1292079 @default.
• W2109049969 hasConceptScore W2109049969C153911025 @default.
• W2109049969 hasConceptScore W2109049969C159048773 @default.
• W2109049969 hasConceptScore W2109049969C170493617 @default.
• W2109049969 hasConceptScore W2109049969C185592680 @default.
• W2109049969 hasConceptScore W2109049969C203014093 @default.
• W2109049969 hasConceptScore W2109049969C2775960820 @default.
• W2109049969 hasConceptScore W2109049969C2776362946 @default.
• W2109049969 hasConceptScore W2109049969C2777292125 @default.
• W2109049969 hasConceptScore W2109049969C2777557582 @default.
• W2109049969 hasConceptScore W2109049969C2778886182 @default.

• next