Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109061954> ?p ?o ?g. }
- W2109061954 endingPage "53" @default.
- W2109061954 startingPage "40" @default.
- W2109061954 abstract "Cardiovascular disease (CVD) remains one of the leading causes of morbidity and mortality in the developed world, and there is a clear need to develop novel therapeutic strategies to reduce cardiovascular risk further than is currently possible. Traditionally, the effectiveness of new cardiovascular drugs has been evaluated in clinical trials using cardiovascular outcomes as endpoints. However, such trials require large numbers of patients followed over long periods of time. Clinical trials using surrogate markers for CVD may be shorter in duration and involve fewer participants. Measurement of atherosclerotic progression is an ideal surrogate marker as it is predictive of future cardiovascular events. The “gold standard” for detecting and defining the severity, extent, and rate of atherosclerotic progression has been quantitative coronary angiography. However, this technique has fundamental limitations. More recently, measurement of carotid intima-media thickness using B-mode ultrasound and measurement of atheroma volume using intravascular ultrasound have emerged as more accurate techniques for detecting atherosclerotic progression. Both of these techniques have potential utility as surrogate endpoints in place of cardiovascular outcomes in clinical trials. Their use might facilitate the more rapid development of novel, safe, and effective therapies." @default.
- W2109061954 created "2016-06-24" @default.
- W2109061954 creator A5040162127 @default.
- W2109061954 creator A5050786891 @default.
- W2109061954 creator A5051403789 @default.
- W2109061954 creator A5056173898 @default.
- W2109061954 creator A5061676012 @default.
- W2109061954 date "2007-02-28" @default.
- W2109061954 modified "2023-10-16" @default.
- W2109061954 title "Biomarkers in the Prevention and Treatment of Atherosclerosis: Need, Validation, and Future" @default.
- W2109061954 cites W1966817707 @default.
- W2109061954 cites W1971217345 @default.
- W2109061954 cites W1973391096 @default.
- W2109061954 cites W1974015788 @default.
- W2109061954 cites W1978623283 @default.
- W2109061954 cites W1981237781 @default.
- W2109061954 cites W1982080117 @default.
- W2109061954 cites W1982982654 @default.
- W2109061954 cites W1985932775 @default.
- W2109061954 cites W1992894877 @default.
- W2109061954 cites W1994154940 @default.
- W2109061954 cites W1995409872 @default.
- W2109061954 cites W2003307830 @default.
- W2109061954 cites W2005786831 @default.
- W2109061954 cites W2016746678 @default.
- W2109061954 cites W2018938059 @default.
- W2109061954 cites W2020632420 @default.
- W2109061954 cites W2025321056 @default.
- W2109061954 cites W2026651190 @default.
- W2109061954 cites W2028728862 @default.
- W2109061954 cites W2032485049 @default.
- W2109061954 cites W2049170821 @default.
- W2109061954 cites W2049184091 @default.
- W2109061954 cites W2052176508 @default.
- W2109061954 cites W2058331351 @default.
- W2109061954 cites W2058610272 @default.
- W2109061954 cites W2058709767 @default.
- W2109061954 cites W2061800560 @default.
- W2109061954 cites W2062241462 @default.
- W2109061954 cites W2063058274 @default.
- W2109061954 cites W2065604182 @default.
- W2109061954 cites W2066711466 @default.
- W2109061954 cites W2079307913 @default.
- W2109061954 cites W2079522334 @default.
- W2109061954 cites W2081708907 @default.
- W2109061954 cites W2084093517 @default.
- W2109061954 cites W2087287221 @default.
- W2109061954 cites W2089900480 @default.
- W2109061954 cites W2094941678 @default.
- W2109061954 cites W2095507444 @default.
- W2109061954 cites W2100083473 @default.
- W2109061954 cites W2102006980 @default.
- W2109061954 cites W2102899779 @default.
- W2109061954 cites W2105187058 @default.
- W2109061954 cites W2107165713 @default.
- W2109061954 cites W2107948144 @default.
- W2109061954 cites W2108668893 @default.
- W2109061954 cites W2111779767 @default.
- W2109061954 cites W2112618189 @default.
- W2109061954 cites W2118154631 @default.
- W2109061954 cites W2120491756 @default.
- W2109061954 cites W2122146058 @default.
- W2109061954 cites W2129617639 @default.
- W2109061954 cites W2131275408 @default.
- W2109061954 cites W2131334142 @default.
- W2109061954 cites W2131343690 @default.
- W2109061954 cites W2133954443 @default.
- W2109061954 cites W2140510131 @default.
- W2109061954 cites W2143421233 @default.
- W2109061954 cites W2145799136 @default.
- W2109061954 cites W2146228563 @default.
- W2109061954 cites W2149042652 @default.
- W2109061954 cites W2153788691 @default.
- W2109061954 cites W2157857368 @default.
- W2109061954 cites W2159449551 @default.
- W2109061954 cites W2162922521 @default.
- W2109061954 cites W2163092745 @default.
- W2109061954 cites W2166910397 @default.
- W2109061954 cites W2169336862 @default.
- W2109061954 cites W2169535116 @default.
- W2109061954 cites W2316167515 @default.
- W2109061954 cites W2316376271 @default.
- W2109061954 cites W2324712847 @default.
- W2109061954 cites W2329619445 @default.
- W2109061954 cites W4230870013 @default.
- W2109061954 doi "https://doi.org/10.1124/pr.59.1.1" @default.
- W2109061954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17329547" @default.
- W2109061954 hasPublicationYear "2007" @default.
- W2109061954 type Work @default.
- W2109061954 sameAs 2109061954 @default.
- W2109061954 citedByCount "64" @default.
- W2109061954 countsByYear W21090619542012 @default.
- W2109061954 countsByYear W21090619542013 @default.
- W2109061954 countsByYear W21090619542014 @default.
- W2109061954 countsByYear W21090619542015 @default.
- W2109061954 countsByYear W21090619542016 @default.
- W2109061954 countsByYear W21090619542017 @default.
- W2109061954 countsByYear W21090619542019 @default.