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- W2109071217 abstract "Nomifensine (Nom), an antidepressant which activates dopamine (DA) transmission mainly by inhibiting DA reuptake in the central nervous system, was assessed as a tool for distinguishing between tumorous and nontumorous hyperprolactinemia (Hper-PRL). The criterion adopted to define responsiveness to Nom was 30% or more suppression below baseline of the plasma PRL concentrations in samples collected within the 120- to 240-min postdrug interval. In 27 Hyper-PRL subjects in whom the existence of a tumor was subsequently established at surgery (25 prolactinoma, 1 ependymoma, and 1 cholesteatoma) and in 13 subjects with roentgenographic alterations of the sella turcica unequivocal for the presence of pituitary tumors, oral administration of Nom (200 mg) did not significantly lower baseline plasma PRL levels. In 46 Hyper-PRL subjects with no or only equivocal alterations of the sella turcica, Nom was effective in lowering plasma PRL in 14 subjects and ineffective in the remaining 32 subjects. It is of note that ..." @default.
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- W2109071217 date "1980-09-01" @default.
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- W2109071217 title "Prolactin Responsiveness to Nomifensine in Patients with Hyperprolactinemia of Tumorous or Uncertain Etiology*" @default.
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- W2109071217 doi "https://doi.org/10.1210/jcem-51-3-650" @default.
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