FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109072308> ?p ?o ?g. }

• W2109072308 endingPage "5932" @default.
• W2109072308 startingPage "5928" @default.
• W2109072308 abstract "Cell cycle, apoptosis, and replicative senescence are all influenced by the cyclin-dependent kinase inhibitor, p21. It was previously reported that deletion of p21 in 129/Sv x C57BL/6 mixed genetic background mice induced a severe lupus-like disease, almost exclusively in females. However, we did not confirm this finding in an independently derived stock of 129/Sv x C57BL/6 p21(-/-) mice. To further address this discrepancy, we examined the effects of p21 deletion in BXSB female mice that develop late-life, mild lupus-like disease. Survival, polyclonal Igs, anti-chromatin Abs, and kidney histopathology in these mice were unremarkable and identical to wild-type littermates for up to 14 mo of age. We conclude that p21 deficiency does not promote autoimmunity even in females of a predisposed strain. The findings indicate that the use of mixed background 129/Sv x C57BL/6 mice to study effects of gene deletions in systemic autoimmunity may be confounded by the genetic heterogeneity of this cross. We suggest that studies addressing gene deletion effects in systemic autoimmunity should use sufficiently backcrossed mice to attain genetic homogeneity, include wild-type littermate controls, and preferentially use congenic inbred strains with late-life lupus predisposition to emulate the polygenic nature of this disease." @default.
• W2109072308 created "2016-06-24" @default.
• W2109072308 creator A5004663851 @default.
• W2109072308 creator A5038738015 @default.
• W2109072308 creator A5051438513 @default.
• W2109072308 date "2002-06-01" @default.
• W2109072308 modified "2023-10-12" @default.
• W2109072308 title "Deletion of p21 (WAF-1/Cip1) Does Not Induce Systemic Autoimmunity in Female BXSB Mice" @default.
• W2109072308 cites W1505469822 @default.
• W2109072308 cites W1599982743 @default.
• W2109072308 cites W1622739787 @default.
• W2109072308 cites W1636013522 @default.
• W2109072308 cites W190488077 @default.
• W2109072308 cites W1967690365 @default.
• W2109072308 cites W1981482475 @default.
• W2109072308 cites W2003893627 @default.
• W2109072308 cites W2007772649 @default.
• W2109072308 cites W2029082526 @default.
• W2109072308 cites W2044057392 @default.
• W2109072308 cites W2050149433 @default.
• W2109072308 cites W2059102619 @default.
• W2109072308 cites W2067217824 @default.
• W2109072308 cites W2071753279 @default.
• W2109072308 cites W2093958228 @default.
• W2109072308 cites W2095533402 @default.
• W2109072308 cites W2111420633 @default.
• W2109072308 cites W2118210213 @default.
• W2109072308 cites W2133175085 @default.
• W2109072308 cites W2135403088 @default.
• W2109072308 cites W2139913587 @default.
• W2109072308 cites W2148607448 @default.
• W2109072308 cites W2156451662 @default.
• W2109072308 cites W2169018274 @default.
• W2109072308 cites W2227157639 @default.
• W2109072308 doi "https://doi.org/10.4049/jimmunol.168.11.5928" @default.
• W2109072308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12023399" @default.
• W2109072308 hasPublicationYear "2002" @default.
• W2109072308 type Work @default.
• W2109072308 sameAs 2109072308 @default.
• W2109072308 citedByCount "24" @default.
• W2109072308 countsByYear W21090723082012 @default.
• W2109072308 countsByYear W21090723082013 @default.
• W2109072308 countsByYear W21090723082014 @default.
• W2109072308 countsByYear W21090723082020 @default.
• W2109072308 crossrefType "journal-article" @default.
• W2109072308 hasAuthorship W2109072308A5004663851 @default.
• W2109072308 hasAuthorship W2109072308A5038738015 @default.
• W2109072308 hasAuthorship W2109072308A5051438513 @default.
• W2109072308 hasBestOaLocation W21090723081 @default.
• W2109072308 hasConcept C104317684 @default.
• W2109072308 hasConcept C126322002 @default.
• W2109072308 hasConcept C159654299 @default.
• W2109072308 hasConcept C190283241 @default.
• W2109072308 hasConcept C203014093 @default.
• W2109072308 hasConcept C2776912625 @default.
• W2109072308 hasConcept C2779134260 @default.
• W2109072308 hasConcept C2780130043 @default.
• W2109072308 hasConcept C31573885 @default.
• W2109072308 hasConcept C33195913 @default.
• W2109072308 hasConcept C522857546 @default.
• W2109072308 hasConcept C54355233 @default.
• W2109072308 hasConcept C71924100 @default.
• W2109072308 hasConcept C84951073 @default.
• W2109072308 hasConcept C86803240 @default.
• W2109072308 hasConcept C98424977 @default.
• W2109072308 hasConceptScore W2109072308C104317684 @default.
• W2109072308 hasConceptScore W2109072308C126322002 @default.
• W2109072308 hasConceptScore W2109072308C159654299 @default.
• W2109072308 hasConceptScore W2109072308C190283241 @default.
• W2109072308 hasConceptScore W2109072308C203014093 @default.
• W2109072308 hasConceptScore W2109072308C2776912625 @default.
• W2109072308 hasConceptScore W2109072308C2779134260 @default.
• W2109072308 hasConceptScore W2109072308C2780130043 @default.
• W2109072308 hasConceptScore W2109072308C31573885 @default.
• W2109072308 hasConceptScore W2109072308C33195913 @default.
• W2109072308 hasConceptScore W2109072308C522857546 @default.
• W2109072308 hasConceptScore W2109072308C54355233 @default.
• W2109072308 hasConceptScore W2109072308C71924100 @default.
• W2109072308 hasConceptScore W2109072308C84951073 @default.
• W2109072308 hasConceptScore W2109072308C86803240 @default.
• W2109072308 hasConceptScore W2109072308C98424977 @default.
• W2109072308 hasIssue "11" @default.
• W2109072308 hasLocation W21090723081 @default.
• W2109072308 hasLocation W21090723082 @default.
• W2109072308 hasOpenAccess W2109072308 @default.
• W2109072308 hasPrimaryLocation W21090723081 @default.
• W2109072308 hasRelatedWork W1175275987 @default.
• W2109072308 hasRelatedWork W1965215187 @default.
• W2109072308 hasRelatedWork W1982601313 @default.
• W2109072308 hasRelatedWork W2009872487 @default.
• W2109072308 hasRelatedWork W2050258751 @default.
• W2109072308 hasRelatedWork W2339701574 @default.
• W2109072308 hasRelatedWork W2349801336 @default.
• W2109072308 hasRelatedWork W2370409175 @default.
• W2109072308 hasRelatedWork W2372948955 @default.
• W2109072308 hasRelatedWork W3032774863 @default.
• W2109072308 hasVolume "168" @default.
• W2109072308 isParatext "false" @default.

• next