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- W2109080201 endingPage "1811" @default.
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- W2109080201 abstract "Secondary homochiral lithium amides derived from α-methylbenzylamine undergo highly diastereoselective conjugate additions to a range of α,β-unsaturated esters. The corresponding β-amino acids are readily liberated by successive N-debenzylation and ester hydrolysis, furnishing (R)-β-amino butyric acid, (R)-β-amino pentanoic acid, (S)-β-leucine, (R)-β-amino octanoic acid, (S)-β-phenylalanine, (S)-β-tyrosine methyl ether, (S)-β-tyrosine hydrochloride and (S)-β-(2-methoxyphenyl)-β-amino propanoic acid in high yields and high ee. The application of this procedure to the synthesis of the natural products (R)-β-DOPA and (R)-β-lysine is demonstrated. The development of a simplified one-pot reaction protocol applicable to the multi-gram scale synthesis of homochiral β-amino esters is also delineated." @default.
- W2109080201 created "2016-06-24" @default.
- W2109080201 creator A5002441008 @default.
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- W2109080201 date "2006-07-01" @default.
- W2109080201 modified "2023-10-15" @default.
- W2109080201 title "Homochiral lithium amides for the asymmetric synthesis of β-amino acids" @default.
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- W2109080201 doi "https://doi.org/10.1016/j.tetasy.2006.05.008" @default.
- W2109080201 hasPublicationYear "2006" @default.