Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109090890> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2109090890 endingPage "77" @default.
- W2109090890 startingPage "73" @default.
- W2109090890 abstract "Twelve patients undergoing total hip replacement were given 600 mg of linezolid as a 20 min iv infusion along with conventional prophylaxis of 1 g of cefamandole immediately before surgery. Routine total hip arthroplasty was carried out, and at timed intervals during surgery samples of bone, fat, muscle and blood were collected for assay by high-performance liquid chromatography analysis. Samples of the haematoma fluid that formed around the operation site and further blood samples for assay were also collected at timed intervals following the operation. The penetration of linezolid into bone was rapid, with mean concentrations of 9.1 mg/L (95% CI 7.7-10.6 mg/L) achieved at 10 min after the infusion, decreasing to 6.3 mg/L (95% CI 3.9-8.6 mg/L) at 30 min. Correction for the simultaneous blood concentrations gave mean values for bone penetration of 51% at 10 min, 60% at 20 min and 47% at 30 min. Although the penetration of linezolid into fat was also rapid, mean concentrations and degree of penetration were c. 60% of those in bone; at 10 min they were 4.5 mg/L (95% CI 3.0-6.1 mg/L; penetration 27%); at 20 min they were 5.2 mg/L (95% CI 4.0-6.4 mg/L; penetration 37%); and at 30 min, 4.1 mg/L (95% CI 3.3-4.8 mg/L; penetration 31%). For muscle the corresponding values were 10.4 mg/L (95% CI 8.1-12.7 mg/L; penetration 58%) at 10 min, 13.4 mg/L (95% CI 10.2-16.5 mg/L; penetration 94%) at 20 min and 12.0 mg/L (95% CI 9.2-14.8 mg/L; penetration 93%) at 30 min. Mean concentrations of linezolid in the haematoma fluid drained from around the operation site were 8.2 mg/L at 6-8 h and 5.6 mg/L at 10-12 h after the infusion, and 7.0 mg/L at 2-4 h following a second 600 mg infusion given 12 h post-operatively. We conclude that linezolid exhibits rapid penetration into bone, fat and muscle of patients undergoing hip arthroplasty, to achieve levels in excess of its MIC for susceptible organisms (< or=4 mg/L); therapeutic concentrations were maintained in the haematoma fluid that surrounds the operation site for >16 h." @default.
- W2109090890 created "2016-06-24" @default.
- W2109090890 creator A5033242621 @default.
- W2109090890 date "2002-07-01" @default.
- W2109090890 modified "2023-10-13" @default.
- W2109090890 title "Penetration of linezolid into bone, fat, muscle and haematoma of patients undergoing routine hip replacement" @default.
- W2109090890 cites W1966894730 @default.
- W2109090890 cites W1975061606 @default.
- W2109090890 cites W2020661402 @default.
- W2109090890 cites W2069937384 @default.
- W2109090890 cites W2099446110 @default.
- W2109090890 cites W2117409056 @default.
- W2109090890 cites W2135869309 @default.
- W2109090890 cites W2138500207 @default.
- W2109090890 cites W2153781972 @default.
- W2109090890 cites W2162398839 @default.
- W2109090890 cites W2163310337 @default.
- W2109090890 cites W2186778839 @default.
- W2109090890 doi "https://doi.org/10.1093/jac/dkf066" @default.
- W2109090890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12096009" @default.
- W2109090890 hasPublicationYear "2002" @default.
- W2109090890 type Work @default.
- W2109090890 sameAs 2109090890 @default.
- W2109090890 citedByCount "173" @default.
- W2109090890 countsByYear W21090908902012 @default.
- W2109090890 countsByYear W21090908902013 @default.
- W2109090890 countsByYear W21090908902014 @default.
- W2109090890 countsByYear W21090908902015 @default.
- W2109090890 countsByYear W21090908902016 @default.
- W2109090890 countsByYear W21090908902017 @default.
- W2109090890 countsByYear W21090908902018 @default.
- W2109090890 countsByYear W21090908902019 @default.
- W2109090890 countsByYear W21090908902020 @default.
- W2109090890 countsByYear W21090908902021 @default.
- W2109090890 countsByYear W21090908902022 @default.
- W2109090890 countsByYear W21090908902023 @default.
- W2109090890 crossrefType "journal-article" @default.
- W2109090890 hasAuthorship W2109090890A5033242621 @default.
- W2109090890 hasBestOaLocation W21090908901 @default.
- W2109090890 hasConcept C127413603 @default.
- W2109090890 hasConcept C141071460 @default.
- W2109090890 hasConcept C185592680 @default.
- W2109090890 hasConcept C2778980435 @default.
- W2109090890 hasConcept C2779489039 @default.
- W2109090890 hasConcept C2780463255 @default.
- W2109090890 hasConcept C2781414143 @default.
- W2109090890 hasConcept C42219234 @default.
- W2109090890 hasConcept C42475967 @default.
- W2109090890 hasConcept C501593827 @default.
- W2109090890 hasConcept C523546767 @default.
- W2109090890 hasConcept C54355233 @default.
- W2109090890 hasConcept C55493867 @default.
- W2109090890 hasConcept C64778159 @default.
- W2109090890 hasConcept C71924100 @default.
- W2109090890 hasConcept C80107235 @default.
- W2109090890 hasConcept C86803240 @default.
- W2109090890 hasConceptScore W2109090890C127413603 @default.
- W2109090890 hasConceptScore W2109090890C141071460 @default.
- W2109090890 hasConceptScore W2109090890C185592680 @default.
- W2109090890 hasConceptScore W2109090890C2778980435 @default.
- W2109090890 hasConceptScore W2109090890C2779489039 @default.
- W2109090890 hasConceptScore W2109090890C2780463255 @default.
- W2109090890 hasConceptScore W2109090890C2781414143 @default.
- W2109090890 hasConceptScore W2109090890C42219234 @default.
- W2109090890 hasConceptScore W2109090890C42475967 @default.
- W2109090890 hasConceptScore W2109090890C501593827 @default.
- W2109090890 hasConceptScore W2109090890C523546767 @default.
- W2109090890 hasConceptScore W2109090890C54355233 @default.
- W2109090890 hasConceptScore W2109090890C55493867 @default.
- W2109090890 hasConceptScore W2109090890C64778159 @default.
- W2109090890 hasConceptScore W2109090890C71924100 @default.
- W2109090890 hasConceptScore W2109090890C80107235 @default.
- W2109090890 hasConceptScore W2109090890C86803240 @default.
- W2109090890 hasIssue "1" @default.
- W2109090890 hasLocation W21090908901 @default.
- W2109090890 hasLocation W21090908902 @default.
- W2109090890 hasOpenAccess W2109090890 @default.
- W2109090890 hasPrimaryLocation W21090908901 @default.
- W2109090890 hasRelatedWork W2003938723 @default.
- W2109090890 hasRelatedWork W2047967234 @default.
- W2109090890 hasRelatedWork W2118496982 @default.
- W2109090890 hasRelatedWork W2364998975 @default.
- W2109090890 hasRelatedWork W2369162477 @default.
- W2109090890 hasRelatedWork W2439875401 @default.
- W2109090890 hasRelatedWork W2748952813 @default.
- W2109090890 hasRelatedWork W2899084033 @default.
- W2109090890 hasRelatedWork W4238867864 @default.
- W2109090890 hasRelatedWork W2525756941 @default.
- W2109090890 hasVolume "50" @default.
- W2109090890 isParatext "false" @default.
- W2109090890 isRetracted "false" @default.
- W2109090890 magId "2109090890" @default.
- W2109090890 workType "article" @default.