Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109096578> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2109096578 abstract "It has been postulated that telomere dysfunction and telomerase activation have important roles in prostate tumorigenesis. Since the ataxia-telangiectasia mutated gene product (ATM protein) is involved in maintaining telomere length and integrity, we hypothesized that its expression might be altered in prostate tumors and, thus, examined its profile in 49 tumor samples. The majority (32/49) had ATM protein levels higher than those observed in normal tissues, with only 5 of 49 tissue samples showing reduced or absent ATM levels. Three of these were from the group of 6 young-onset or sibling-pair tumors. There was a trend toward higher ATM expression in tumors with a higher Gleason score (23/32 [72%] for grade 8-10 vs 9/17 [53%] for grades 5-7), although this difference was not statistically significant. These findings support our hypothesis that the presence of the ATM protein at the same or a higher level than that in normal prostate cells might have an important role in the maintenance of the shortened telomeres commonly found in prostate cancer cells." @default.
- W2109096578 created "2016-06-24" @default.
- W2109096578 creator A5010113291 @default.
- W2109096578 creator A5011222815 @default.
- W2109096578 creator A5019481184 @default.
- W2109096578 creator A5061733681 @default.
- W2109096578 creator A5076754182 @default.
- W2109096578 creator A5081886381 @default.
- W2109096578 date "2004-02-01" @default.
- W2109096578 modified "2023-09-23" @default.
- W2109096578 title "ATM Protein Overexpression in Prostate Tumors Possible Role in Telomere Maintenance" @default.
- W2109096578 cites W1516734969 @default.
- W2109096578 cites W1976240148 @default.
- W2109096578 cites W1980695429 @default.
- W2109096578 cites W1995365852 @default.
- W2109096578 cites W2023276228 @default.
- W2109096578 cites W2030188161 @default.
- W2109096578 cites W2064727462 @default.
- W2109096578 cites W2078465024 @default.
- W2109096578 cites W2087321474 @default.
- W2109096578 cites W2130758991 @default.
- W2109096578 cites W2155984586 @default.
- W2109096578 cites W2160840611 @default.
- W2109096578 cites W2162923066 @default.
- W2109096578 cites W2164639950 @default.
- W2109096578 cites W3187872748 @default.
- W2109096578 doi "https://doi.org/10.1309/jtkg-ggku-rfx3-xmgt" @default.
- W2109096578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14983937" @default.
- W2109096578 hasPublicationYear "2004" @default.
- W2109096578 type Work @default.
- W2109096578 sameAs 2109096578 @default.
- W2109096578 citedByCount "13" @default.
- W2109096578 countsByYear W21090965782012 @default.
- W2109096578 countsByYear W21090965782013 @default.
- W2109096578 countsByYear W21090965782014 @default.
- W2109096578 countsByYear W21090965782016 @default.
- W2109096578 countsByYear W21090965782017 @default.
- W2109096578 countsByYear W21090965782018 @default.
- W2109096578 countsByYear W21090965782019 @default.
- W2109096578 countsByYear W21090965782022 @default.
- W2109096578 crossrefType "journal-article" @default.
- W2109096578 hasAuthorship W2109096578A5010113291 @default.
- W2109096578 hasAuthorship W2109096578A5011222815 @default.
- W2109096578 hasAuthorship W2109096578A5019481184 @default.
- W2109096578 hasAuthorship W2109096578A5061733681 @default.
- W2109096578 hasAuthorship W2109096578A5076754182 @default.
- W2109096578 hasAuthorship W2109096578A5081886381 @default.
- W2109096578 hasBestOaLocation W21090965781 @default.
- W2109096578 hasConcept C104317684 @default.
- W2109096578 hasConcept C121608353 @default.
- W2109096578 hasConcept C142724271 @default.
- W2109096578 hasConcept C177336024 @default.
- W2109096578 hasConcept C2776235491 @default.
- W2109096578 hasConcept C2780192828 @default.
- W2109096578 hasConcept C502942594 @default.
- W2109096578 hasConcept C54355233 @default.
- W2109096578 hasConcept C555283112 @default.
- W2109096578 hasConcept C71924100 @default.
- W2109096578 hasConcept C86803240 @default.
- W2109096578 hasConcept C94581717 @default.
- W2109096578 hasConceptScore W2109096578C104317684 @default.
- W2109096578 hasConceptScore W2109096578C121608353 @default.
- W2109096578 hasConceptScore W2109096578C142724271 @default.
- W2109096578 hasConceptScore W2109096578C177336024 @default.
- W2109096578 hasConceptScore W2109096578C2776235491 @default.
- W2109096578 hasConceptScore W2109096578C2780192828 @default.
- W2109096578 hasConceptScore W2109096578C502942594 @default.
- W2109096578 hasConceptScore W2109096578C54355233 @default.
- W2109096578 hasConceptScore W2109096578C555283112 @default.
- W2109096578 hasConceptScore W2109096578C71924100 @default.
- W2109096578 hasConceptScore W2109096578C86803240 @default.
- W2109096578 hasConceptScore W2109096578C94581717 @default.
- W2109096578 hasLocation W21090965781 @default.
- W2109096578 hasLocation W21090965782 @default.
- W2109096578 hasOpenAccess W2109096578 @default.
- W2109096578 hasPrimaryLocation W21090965781 @default.
- W2109096578 hasRelatedWork W2054091971 @default.
- W2109096578 hasRelatedWork W2074188486 @default.
- W2109096578 hasRelatedWork W2091699981 @default.
- W2109096578 hasRelatedWork W2140117316 @default.
- W2109096578 hasRelatedWork W2143347912 @default.
- W2109096578 hasRelatedWork W2154837214 @default.
- W2109096578 hasRelatedWork W2164639950 @default.
- W2109096578 hasRelatedWork W2768923159 @default.
- W2109096578 hasRelatedWork W2795210755 @default.
- W2109096578 hasRelatedWork W334808203 @default.
- W2109096578 isParatext "false" @default.
- W2109096578 isRetracted "false" @default.
- W2109096578 magId "2109096578" @default.
- W2109096578 workType "article" @default.