FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109097294> ?p ?o ?g. }

• W2109097294 endingPage "117" @default.
• W2109097294 startingPage "113" @default.
• W2109097294 abstract "<h3>Objective:</h3> Previous histochemical studies in the demyelinating form of Guillain-Barré syndrome (GBS), acute inflammatory demyelinating polyneuropathy (AIDP), have shown complement deposition on the surface of Schwann cells, and therefore unknown epitopes would be present on the outer surface of Schwann cells. <h3>Methods:</h3> We used a proteomic-based approach to search for the target molecules of AIDP in the extracted proteins from schwannoma cells. Sera were obtained from 40 patients with GBS, 31 controls with inflammatory disease, and 46 normal controls. <h3>Results:</h3> We found that patients with AIDP after cytomegalovirus (CMV) infection have serum autoantibodies against membrane-organizing extension spike protein (moesin), which is expressed in the Schwann cell processes at the nodes of Ranvier and is crucial for myelination. Of the 40 patients with GBS, 6 had recent CMV infection and 5 of them (83%) had high levels of serum immunoglobulin G antibodies against moesin. The anti-moesin antibodies were found in none of the control subjects with disease including 5 with CMV infection but no neuropathy, and only 2 (4%) of the 46 normal control subjects. Immunocytochemistry showed that moesin was stained at the distal tips of schwannoma cells by sera from the patients with CMV-related AIDP but not by sera from controls. <h3>Conclusion:</h3> Moesin is a possible immunologic target molecule of pathogenic autoantibodies in patients with CMV-related AIDP. <h3>Classification of evidence:</h3> This study provides Class II evidence that levels of serum anti-moesin antibodies accurately distinguishes CMV-related AIDP from non–CMV-related AIDP (sensitivity 83%, specificity 93%)." @default.
• W2109097294 created "2016-06-24" @default.
• W2109097294 creator A5000527844 @default.
• W2109097294 creator A5004889289 @default.
• W2109097294 creator A5005333448 @default.
• W2109097294 creator A5009588500 @default.
• W2109097294 creator A5012393967 @default.
• W2109097294 creator A5018146056 @default.
• W2109097294 creator A5032735315 @default.
• W2109097294 creator A5035507863 @default.
• W2109097294 creator A5037584672 @default.
• W2109097294 creator A5042556610 @default.
• W2109097294 creator A5043458895 @default.
• W2109097294 creator A5047285396 @default.
• W2109097294 creator A5056390161 @default.
• W2109097294 creator A5063813350 @default.
• W2109097294 creator A5065317007 @default.
• W2109097294 creator A5086153164 @default.
• W2109097294 creator A5090310364 @default.
• W2109097294 date "2014-06-11" @default.
• W2109097294 modified "2023-09-25" @default.
• W2109097294 title "Moesin is a possible target molecule for cytomegalovirus-related Guillain-Barre syndrome" @default.
• W2109097294 cites W1984695287 @default.
• W2109097294 cites W1991644386 @default.
• W2109097294 cites W1993412762 @default.
• W2109097294 cites W2017281603 @default.
• W2109097294 cites W2027139906 @default.
• W2109097294 cites W2063642387 @default.
• W2109097294 cites W2133545106 @default.
• W2109097294 cites W2147467901 @default.
• W2109097294 cites W2163550872 @default.
• W2109097294 cites W2312774930 @default.
• W2109097294 doi "https://doi.org/10.1212/wnl.0000000000000566" @default.
• W2109097294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25488994" @default.
• W2109097294 hasPublicationYear "2014" @default.
• W2109097294 type Work @default.
• W2109097294 sameAs 2109097294 @default.
• W2109097294 citedByCount "48" @default.
• W2109097294 countsByYear W21090972942014 @default.
• W2109097294 countsByYear W21090972942015 @default.
• W2109097294 countsByYear W21090972942016 @default.
• W2109097294 countsByYear W21090972942017 @default.
• W2109097294 countsByYear W21090972942018 @default.
• W2109097294 countsByYear W21090972942019 @default.
• W2109097294 countsByYear W21090972942020 @default.
• W2109097294 countsByYear W21090972942021 @default.
• W2109097294 countsByYear W21090972942022 @default.
• W2109097294 countsByYear W21090972942023 @default.
• W2109097294 crossrefType "journal-article" @default.
• W2109097294 hasAuthorship W2109097294A5000527844 @default.
• W2109097294 hasAuthorship W2109097294A5004889289 @default.
• W2109097294 hasAuthorship W2109097294A5005333448 @default.
• W2109097294 hasAuthorship W2109097294A5009588500 @default.
• W2109097294 hasAuthorship W2109097294A5012393967 @default.
• W2109097294 hasAuthorship W2109097294A5018146056 @default.
• W2109097294 hasAuthorship W2109097294A5032735315 @default.
• W2109097294 hasAuthorship W2109097294A5035507863 @default.
• W2109097294 hasAuthorship W2109097294A5037584672 @default.
• W2109097294 hasAuthorship W2109097294A5042556610 @default.
• W2109097294 hasAuthorship W2109097294A5043458895 @default.
• W2109097294 hasAuthorship W2109097294A5047285396 @default.
• W2109097294 hasAuthorship W2109097294A5056390161 @default.
• W2109097294 hasAuthorship W2109097294A5063813350 @default.
• W2109097294 hasAuthorship W2109097294A5065317007 @default.
• W2109097294 hasAuthorship W2109097294A5086153164 @default.
• W2109097294 hasAuthorship W2109097294A5090310364 @default.
• W2109097294 hasConcept C142669718 @default.
• W2109097294 hasConcept C142724271 @default.
• W2109097294 hasConcept C1491633281 @default.
• W2109097294 hasConcept C159654299 @default.
• W2109097294 hasConcept C163764329 @default.
• W2109097294 hasConcept C195616568 @default.
• W2109097294 hasConcept C203014093 @default.
• W2109097294 hasConcept C2776292417 @default.
• W2109097294 hasConcept C2780246058 @default.
• W2109097294 hasConcept C54355233 @default.
• W2109097294 hasConcept C71924100 @default.
• W2109097294 hasConcept C86803240 @default.
• W2109097294 hasConceptScore W2109097294C142669718 @default.
• W2109097294 hasConceptScore W2109097294C142724271 @default.
• W2109097294 hasConceptScore W2109097294C1491633281 @default.
• W2109097294 hasConceptScore W2109097294C159654299 @default.
• W2109097294 hasConceptScore W2109097294C163764329 @default.
• W2109097294 hasConceptScore W2109097294C195616568 @default.
• W2109097294 hasConceptScore W2109097294C203014093 @default.
• W2109097294 hasConceptScore W2109097294C2776292417 @default.
• W2109097294 hasConceptScore W2109097294C2780246058 @default.
• W2109097294 hasConceptScore W2109097294C54355233 @default.
• W2109097294 hasConceptScore W2109097294C71924100 @default.
• W2109097294 hasConceptScore W2109097294C86803240 @default.
• W2109097294 hasIssue "2" @default.
• W2109097294 hasLocation W21090972941 @default.
• W2109097294 hasLocation W21090972942 @default.
• W2109097294 hasOpenAccess W2109097294 @default.
• W2109097294 hasPrimaryLocation W21090972941 @default.
• W2109097294 hasRelatedWork W2004845289 @default.
• W2109097294 hasRelatedWork W2024525526 @default.
• W2109097294 hasRelatedWork W2041711747 @default.

• next