Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109099407> ?p ?o ?g. }
- W2109099407 endingPage "522" @default.
- W2109099407 startingPage "509" @default.
- W2109099407 abstract "Colorectal cancer is one of the leading causes of tumor-related morbidity and mortality worldwide. While mechanisms underlying this disease have been elucidated over the past two decades, these molecular insights have failed to translate into efficacious therapy. The oncogenomic view of cancer suggests that terminal transformation reflects the sequential corruption of signal transduction circuits regulating key homeostatic mechanisms, whose multiplicity underlies the therapeutic resistance of most tumors to interventions targeting individual pathways. Conversely, the paucity of mechanistic insights into proximal pathophysiological processes that initiate and amplify oncogenic circuits preceding accumulation of mutations and transformation impedes development of effective prevention and therapy. In that context, guanylyl cyclase C (GCC), the intestinal receptor for the paracrine hormones guanylin and uroguanylin, whose early loss characterizes colorectal transformation, has emerged as a component of lineage-specific homeostatic programs organizing spatiotemporal patterning along the crypt-surface axis. Dysregulation of GCC signaling, reflecting hormone loss, promotes tumorigenesis through reprogramming of replicative and bioenergetic circuits and genomic instability. Compensatory upregulation of GCC in response to hormone loss provides a unique translational opportunity for prevention and treatment of colorectal tumors by hormone-replacement therapy." @default.
- W2109099407 created "2016-06-24" @default.
- W2109099407 creator A5022300126 @default.
- W2109099407 creator A5036674274 @default.
- W2109099407 creator A5062664304 @default.
- W2109099407 creator A5071458554 @default.
- W2109099407 creator A5082988030 @default.
- W2109099407 date "2009-05-01" @default.
- W2109099407 modified "2023-09-23" @default.
- W2109099407 title "Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target" @default.
- W2109099407 cites W1535438232 @default.
- W2109099407 cites W1554815317 @default.
- W2109099407 cites W1569755992 @default.
- W2109099407 cites W1712540979 @default.
- W2109099407 cites W1964680364 @default.
- W2109099407 cites W1966447268 @default.
- W2109099407 cites W1966761605 @default.
- W2109099407 cites W1970744454 @default.
- W2109099407 cites W1973800266 @default.
- W2109099407 cites W1976873804 @default.
- W2109099407 cites W1979618971 @default.
- W2109099407 cites W1980481067 @default.
- W2109099407 cites W1982810858 @default.
- W2109099407 cites W1984012038 @default.
- W2109099407 cites W1984611427 @default.
- W2109099407 cites W1984621921 @default.
- W2109099407 cites W1986500594 @default.
- W2109099407 cites W1989215255 @default.
- W2109099407 cites W1992127683 @default.
- W2109099407 cites W1993238204 @default.
- W2109099407 cites W1996979039 @default.
- W2109099407 cites W1997813173 @default.
- W2109099407 cites W1997826749 @default.
- W2109099407 cites W2001258296 @default.
- W2109099407 cites W2001443196 @default.
- W2109099407 cites W2001568034 @default.
- W2109099407 cites W2002404925 @default.
- W2109099407 cites W2003958144 @default.
- W2109099407 cites W2005865365 @default.
- W2109099407 cites W2006239354 @default.
- W2109099407 cites W2008221746 @default.
- W2109099407 cites W2009857926 @default.
- W2109099407 cites W2011053154 @default.
- W2109099407 cites W2011282245 @default.
- W2109099407 cites W2011810742 @default.
- W2109099407 cites W2011912935 @default.
- W2109099407 cites W2012110850 @default.
- W2109099407 cites W2012276721 @default.
- W2109099407 cites W2013306879 @default.
- W2109099407 cites W2017862163 @default.
- W2109099407 cites W2018348035 @default.
- W2109099407 cites W2018602900 @default.
- W2109099407 cites W2019789647 @default.
- W2109099407 cites W2022572059 @default.
- W2109099407 cites W2023542615 @default.
- W2109099407 cites W2024121049 @default.
- W2109099407 cites W2025225219 @default.
- W2109099407 cites W2025319771 @default.
- W2109099407 cites W2026533505 @default.
- W2109099407 cites W2026778985 @default.
- W2109099407 cites W2027630134 @default.
- W2109099407 cites W2028368645 @default.
- W2109099407 cites W2031522329 @default.
- W2109099407 cites W2032409947 @default.
- W2109099407 cites W2032900031 @default.
- W2109099407 cites W2033486224 @default.
- W2109099407 cites W2034269086 @default.
- W2109099407 cites W2034375388 @default.
- W2109099407 cites W2035640880 @default.
- W2109099407 cites W2036147050 @default.
- W2109099407 cites W2039210770 @default.
- W2109099407 cites W2040566047 @default.
- W2109099407 cites W2040942754 @default.
- W2109099407 cites W2042922199 @default.
- W2109099407 cites W2043103956 @default.
- W2109099407 cites W2046976278 @default.
- W2109099407 cites W2050397881 @default.
- W2109099407 cites W2051070943 @default.
- W2109099407 cites W2052319461 @default.
- W2109099407 cites W2056137479 @default.
- W2109099407 cites W2057224405 @default.
- W2109099407 cites W2057830803 @default.
- W2109099407 cites W2058138221 @default.
- W2109099407 cites W2058785803 @default.
- W2109099407 cites W2059430254 @default.
- W2109099407 cites W2059813946 @default.
- W2109099407 cites W2060041328 @default.
- W2109099407 cites W2060628991 @default.
- W2109099407 cites W2065431388 @default.
- W2109099407 cites W2066140100 @default.
- W2109099407 cites W2066171378 @default.
- W2109099407 cites W2070453770 @default.
- W2109099407 cites W2071697240 @default.
- W2109099407 cites W2071937135 @default.
- W2109099407 cites W2072939418 @default.
- W2109099407 cites W2076103389 @default.
- W2109099407 cites W2081985759 @default.
- W2109099407 cites W2085669292 @default.