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• W2109103024 endingPage "4111" @default.
• W2109103024 startingPage "4102" @default.
• W2109103024 abstract "ABSTRACT CD44 has been implicated in immune and inflammatory processes. We have analyzed the role of CD44 in the outcome of Listeria monocytogenes infection in murine bone marrow-derived macrophages (BMM). Surprisingly, a dramatically decreased intracellular survival of L. monocytogenes was observed in CD44 −/− BMM. CD44 −/− heart or lung fibroblast cultures also showed reduced bacterial levels. Moreover, livers from CD44 −/− -infected mice showed diminished levels of L. monocytogenes . In contrast, intracellular growth of Salmonella enterica serovar Typhimurium was the same in CD44 −/− and control BMM. The CD44-mediated increased bacterial proliferation was not linked to altered BMM differentiation or to secretion of soluble factors. CD44 did not mediate listerial uptake, and it played no role in bacterial escape from the primary phagosome or formation of actin tails. Furthermore, CD44-enhanced listerial proliferation occurred in the absence of intracellular bacterial spreading. Interestingly, coincubation of BMM with hyaluronidase or anti-CD44 antibodies that selectively inhibit hyaluronan binding increased intracellular listerial proliferation. Treatment of cells with hyaluronan, in contrast, diminished listerial growth and induced proinflammatory transcript levels. We suggest that L. monocytogenes takes advantage of the CD44-mediated signaling to proliferate intracellularly, although binding of CD44 to certain ligands will inhibit such response." @default.
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• W2109103024 date "2003-07-01" @default.
• W2109103024 modified "2023-10-10" @default.
• W2109103024 title "CD44-Regulated Intracellular Proliferation of<i>Listeria monocytogenes</i>" @default.
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• W2109103024 doi "https://doi.org/10.1128/iai.71.7.4102-4111.2003" @default.
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