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- W2109104501 abstract "Understanding the distribution of velocities of identical motors as they walk along polar tracks is important in deciphering their locomotion mechanism. We created a three parameter kinetic model to describe the velocity, $P(v)$, and run-length distributions of generic molecular motors that step (forward and backward) on a track and have finite processivity. We obtain exact analytic results for the run-length and velocity distributions as a function of external resistive force. Remarkably, our theory fits Kinesin-1 data very well at zero force, and reproduces measured stall-force and ratio of the stepping rates. We extend the model to predict the behavior of Kinesin-1 velocity distributions under load. When extended to non-zero loads, the theory makes two interesting predictions. One is that the $P(v)$ is non-Gaussian and the other is a bimodal structure in $P(v)$. The bimodal structure, a feature that remains even with a finite step-size distribution, is a direct consequence of the discrete step-size of Kinesin-1. Although we analyze only Kinesin-1 data, our results are general and should hold for any processive motor, which walks on a polar track with a discrete step-size." @default.
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- W2109104501 date "2015-01-01" @default.
- W2109104501 modified "2023-09-28" @default.
- W2109104501 title "Effect of Force and Discrete Step-Size on the Velocity Distribution of Processive Molecular Motors" @default.
- W2109104501 doi "https://doi.org/10.1016/j.bpj.2014.11.755" @default.
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