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- W2109120703 abstract "Statin therapy is highly effective in reducing low-density lipoprotein cholesterol (LDL-C) and cardiovascular events; however, many high-risk patients on statin monotherapy do not achieve sufficient LDL-C lowering. Statin-dose uptitration, switching to more potent statins and/or addition of complementary lipid-lowering drugs has been recommended for these patients. Numerous clinical trials have shown that coadministration of statins with cholesterol absorption inhibitor, ezetimibe, improves LDL-C lowering and other lipid parameters more than statins alone, including doubling the statin dose. In clinical outcome trials, ezetimibe combined with simvastatin reduced ischemic events in high-risk patients with chronic kidney disease and aortic stenosis; the incremental benefit of LDL-C lowering when ezetimibe is added to statin therapy on cardiovascular risk reduction compared with statin monotherapy is currently being evaluated in an ongoing clinical trial. Recently, a fixed-dose combination of ezetimibe plus ..." @default.
- W2109120703 created "2016-06-24" @default.
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- W2109120703 date "2014-08-01" @default.
- W2109120703 modified "2023-10-18" @default.
- W2109120703 title "Efficacy and safety of ezetimibe plus atorvastatin therapy" @default.
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