Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109127788> ?p ?o ?g. }
- W2109127788 abstract "The mesenchymal stem cell (MSC) is being broadly studied in clinical trials. Contrary to the early paradigm of cell replacement and differentiation as a therapeutic mechanism of action, evidence is mounting that the secretions of the cells are responsible for their therapeutic effects. These secretions include molecules and extracellular vesicles that have both local and distant effects. This review summarizes the up- and down-regulation of MSC anti-inflammatory, immune modulating, anti-tumor, and regenerative secretions resulting from different stimuli including: a) hypoxia, which increases the production of growth factors and anti-inflammatory molecules; b) pro-inflammatory stimuli that induce the secretion of immune modulating and anti-inflammatory factors; and c) 3 dimensional growth which up regulates the production of anti-cancer factors and anti-inflammatory molecules compared to monolayer culture. Finally we review in detail the most important factors present in conditioned medium of MSC that can be considered protagonists of MSC physiological effects including HGF, TGF-b, VEGF, TSG-6, PGE2 and galectins 1, and 9. We conclude that there is potential for the development of acellular therapeutic interventions for autoimmune, inflammatory, and malignant diseases and tissue regeneration from cellular secretions derived from MSCs cultured under the appropriate conditions." @default.
- W2109127788 created "2016-06-24" @default.
- W2109127788 creator A5007606932 @default.
- W2109127788 creator A5083320721 @default.
- W2109127788 creator A5089883823 @default.
- W2109127788 date "2014-10-11" @default.
- W2109127788 modified "2023-10-12" @default.
- W2109127788 title "A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods" @default.
- W2109127788 cites W1479842253 @default.
- W2109127788 cites W1487779806 @default.
- W2109127788 cites W1497497385 @default.
- W2109127788 cites W1531093118 @default.
- W2109127788 cites W1546306647 @default.
- W2109127788 cites W1568945049 @default.
- W2109127788 cites W1573256436 @default.
- W2109127788 cites W1589179725 @default.
- W2109127788 cites W1593070855 @default.
- W2109127788 cites W1598936816 @default.
- W2109127788 cites W1603852791 @default.
- W2109127788 cites W1630880489 @default.
- W2109127788 cites W1638424324 @default.
- W2109127788 cites W1640854798 @default.
- W2109127788 cites W1647832452 @default.
- W2109127788 cites W1726957010 @default.
- W2109127788 cites W1788131483 @default.
- W2109127788 cites W1931127206 @default.
- W2109127788 cites W1960997296 @default.
- W2109127788 cites W1963667020 @default.
- W2109127788 cites W1965547342 @default.
- W2109127788 cites W1965953554 @default.
- W2109127788 cites W1966523500 @default.
- W2109127788 cites W1967927207 @default.
- W2109127788 cites W1968254493 @default.
- W2109127788 cites W1968409866 @default.
- W2109127788 cites W1968545038 @default.
- W2109127788 cites W1968559439 @default.
- W2109127788 cites W1969095017 @default.
- W2109127788 cites W1969137358 @default.
- W2109127788 cites W1972171120 @default.
- W2109127788 cites W1972347738 @default.
- W2109127788 cites W1972835138 @default.
- W2109127788 cites W1975603491 @default.
- W2109127788 cites W1976371737 @default.
- W2109127788 cites W1976681765 @default.
- W2109127788 cites W1979497719 @default.
- W2109127788 cites W1982408656 @default.
- W2109127788 cites W1982426523 @default.
- W2109127788 cites W1982861439 @default.
- W2109127788 cites W1982916645 @default.
- W2109127788 cites W1983493560 @default.
- W2109127788 cites W1983970047 @default.
- W2109127788 cites W1986321004 @default.
- W2109127788 cites W1987974662 @default.
- W2109127788 cites W1991311930 @default.
- W2109127788 cites W1994027416 @default.
- W2109127788 cites W1994426347 @default.
- W2109127788 cites W1996389318 @default.
- W2109127788 cites W1999647769 @default.
- W2109127788 cites W2001093897 @default.
- W2109127788 cites W2001353598 @default.
- W2109127788 cites W2002620928 @default.
- W2109127788 cites W2002963491 @default.
- W2109127788 cites W2003079057 @default.
- W2109127788 cites W2011403734 @default.
- W2109127788 cites W2012056552 @default.
- W2109127788 cites W2013039703 @default.
- W2109127788 cites W2013074450 @default.
- W2109127788 cites W2014907034 @default.
- W2109127788 cites W2018013954 @default.
- W2109127788 cites W2018619273 @default.
- W2109127788 cites W2021916724 @default.
- W2109127788 cites W2022614733 @default.
- W2109127788 cites W2023284474 @default.
- W2109127788 cites W2026639735 @default.
- W2109127788 cites W2027183438 @default.
- W2109127788 cites W2029047024 @default.
- W2109127788 cites W2029097180 @default.
- W2109127788 cites W2029584195 @default.
- W2109127788 cites W2029599332 @default.
- W2109127788 cites W2029976265 @default.
- W2109127788 cites W2031356385 @default.
- W2109127788 cites W2033284503 @default.
- W2109127788 cites W2035459661 @default.
- W2109127788 cites W2037395645 @default.
- W2109127788 cites W2039146285 @default.
- W2109127788 cites W2039751388 @default.
- W2109127788 cites W2040481506 @default.
- W2109127788 cites W2040525836 @default.
- W2109127788 cites W2041436853 @default.
- W2109127788 cites W2041529772 @default.
- W2109127788 cites W2044788671 @default.
- W2109127788 cites W2045287986 @default.
- W2109127788 cites W2046237540 @default.
- W2109127788 cites W2047003893 @default.
- W2109127788 cites W2049430343 @default.
- W2109127788 cites W2051255041 @default.
- W2109127788 cites W2051634279 @default.
- W2109127788 cites W2052071472 @default.
- W2109127788 cites W2052504301 @default.
- W2109127788 cites W2053393023 @default.