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- W2109130014 abstract "The innate immune system relies on evolutionally conserved Toll-like receptors (TLRs) to recognize diverse microbial molecular structures. Most TLRs depend on a family of adaptor proteins termed MyD88s to transduce their signals. Critical roles of MyD88-1–4 in host defense were demonstrated by defective immune responses in knockout mice. In contrast, the sites of expression and functions of vertebrate MyD88-5 have remained elusive. We show that MyD88-5 is distinct from other MyD88s in that MyD88-5 is preferentially expressed in neurons, colocalizes in part with mitochondria and JNK3, and regulates neuronal death. We prepared MyD88-5/GFP transgenic mice via a bacterial artificial chromosome to preserve its endogenous expression pattern. MyD88-5/GFP was detected chiefly in the brain, where it associated with punctate structures within neurons and copurified in part with mitochondria. In vitro, MyD88-5 coimmunoprecipitated with JNK3 and recruited JNK3 from cytosol to mitochondria. Hippocampal neurons from MyD88-5–deficient mice were protected from death after deprivation of oxygen and glucose. In contrast, MyD88-5–null macrophages behaved like wild-type cells in their response to microbial products. Thus, MyD88-5 appears unique among MyD88s in functioning to mediate stress-induced neuronal toxicity." @default.
- W2109130014 created "2016-06-24" @default.
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- W2109130014 date "2007-08-27" @default.
- W2109130014 modified "2023-10-15" @default.
- W2109130014 title "MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival" @default.
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- W2109130014 cites W1530284699 @default.
- W2109130014 cites W1557316591 @default.
- W2109130014 cites W1560110579 @default.
- W2109130014 cites W1588312796 @default.
- W2109130014 cites W1779401872 @default.
- W2109130014 cites W1823288226 @default.
- W2109130014 cites W1966772446 @default.
- W2109130014 cites W1967269498 @default.
- W2109130014 cites W1968440197 @default.
- W2109130014 cites W1973227020 @default.
- W2109130014 cites W1975321314 @default.
- W2109130014 cites W1976519846 @default.
- W2109130014 cites W1978720466 @default.
- W2109130014 cites W1979747773 @default.
- W2109130014 cites W1981592463 @default.
- W2109130014 cites W1989656760 @default.
- W2109130014 cites W1993206887 @default.
- W2109130014 cites W1994679263 @default.
- W2109130014 cites W1996120614 @default.
- W2109130014 cites W1996234796 @default.
- W2109130014 cites W2008677145 @default.
- W2109130014 cites W2011089118 @default.
- W2109130014 cites W2013601771 @default.
- W2109130014 cites W2017400430 @default.
- W2109130014 cites W2018834244 @default.
- W2109130014 cites W2023542615 @default.
- W2109130014 cites W2032342779 @default.
- W2109130014 cites W2049874360 @default.
- W2109130014 cites W2052536256 @default.
- W2109130014 cites W2060657842 @default.
- W2109130014 cites W2062601645 @default.
- W2109130014 cites W2068419165 @default.
- W2109130014 cites W2070045384 @default.
- W2109130014 cites W2071162967 @default.
- W2109130014 cites W2071229320 @default.
- W2109130014 cites W2076361525 @default.
- W2109130014 cites W2078534230 @default.
- W2109130014 cites W2078824404 @default.
- W2109130014 cites W2082890018 @default.
- W2109130014 cites W2092896180 @default.
- W2109130014 cites W2095841601 @default.
- W2109130014 cites W2096910934 @default.
- W2109130014 cites W2099954870 @default.
- W2109130014 cites W2101397045 @default.
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- W2109130014 cites W2113019448 @default.
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- W2109130014 cites W2121039111 @default.
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- W2109130014 cites W2123868590 @default.
- W2109130014 cites W2128016761 @default.
- W2109130014 cites W2129328366 @default.
- W2109130014 cites W2130421043 @default.
- W2109130014 cites W2130879335 @default.
- W2109130014 cites W2141982669 @default.
- W2109130014 cites W2143746383 @default.
- W2109130014 cites W2145574997 @default.
- W2109130014 cites W2147038697 @default.
- W2109130014 cites W2148061274 @default.
- W2109130014 cites W2149028037 @default.
- W2109130014 cites W2149789552 @default.
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- W2109130014 doi "https://doi.org/10.1084/jem.20070868" @default.
- W2109130014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2118693" @default.
- W2109130014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17724133" @default.
- W2109130014 hasPublicationYear "2007" @default.
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