Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109131632> ?p ?o ?g. }
- W2109131632 endingPage "654" @default.
- W2109131632 startingPage "646" @default.
- W2109131632 abstract "We investigated rivastigmine effectiveness in 84 Alzheimer outpatients, with a special focus on behavioural problems. Cognition, activities in daily living (ADL) and behaviour were assessed during 30 months. Changes in test results between 6 months and baseline were compared with a historical control cohort of Alzheimer patients (n = 69) by performing t-tests and calculation of Cohen's d and standardised response mean (SRM). During 6 months, rivastigmine showed effect on cognition (p < 0.001, Cohen's d = 0.33, SRM = 0.78), ADL (p < 0.001, Cohen's d = −0.43, SRM = −0.54) and memory-related behaviour (p = 0.006, Cohen's d = −0.28, SRM = −0.28). Depressive behaviour worsened (p = 0.001, Cohen's d = 0.30, SRM = 0.37) and disruptive behaviour (p = 0.369, Cohen's d = −0.07, SRM = −0.09) was not effected by rivastigmine. During 30 months, a gradual decline was shown in most domains. Most RMBPC items showed stabilization during 30 months. Improvement on disruptive behaviour items and depression items was shown after 6 months of treatment in a large proportion of patients in whom behavioural problems were present at baseline. In conclusion, a huge discontinuation rate is experienced within the first half year of treatment. In the subpopulation of patients who continued rivastigmine for 6 months, it shows modest effectiveness on cognition, functionality and memory-associated behaviour compared with historical control patients. Unfortunately, disruptive behaviour is not altered by rivastigmine therapy, and depressive behaviour worsened slightly after initial treatment. During 30 months, rivastigmine showed stabilization on numerous behaviour items as measured by the RMBPC." @default.
- W2109131632 created "2016-06-24" @default.
- W2109131632 creator A5001570809 @default.
- W2109131632 creator A5007703609 @default.
- W2109131632 creator A5022527154 @default.
- W2109131632 creator A5029474399 @default.
- W2109131632 creator A5031115157 @default.
- W2109131632 creator A5050708922 @default.
- W2109131632 creator A5062227574 @default.
- W2109131632 date "2006-05-24" @default.
- W2109131632 modified "2023-09-26" @default.
- W2109131632 title "Treatment effects of rivastigmine on cognition, performance of daily living activities and behaviour in Alzheimer's disease in an outpatient geriatric setting" @default.
- W2109131632 cites W1498917275 @default.
- W2109131632 cites W1847168837 @default.
- W2109131632 cites W1971797932 @default.
- W2109131632 cites W1973512378 @default.
- W2109131632 cites W1976085628 @default.
- W2109131632 cites W1977755787 @default.
- W2109131632 cites W1985528178 @default.
- W2109131632 cites W1986736806 @default.
- W2109131632 cites W2005259934 @default.
- W2109131632 cites W2012987313 @default.
- W2109131632 cites W2013177991 @default.
- W2109131632 cites W2026659454 @default.
- W2109131632 cites W2049066516 @default.
- W2109131632 cites W2060084873 @default.
- W2109131632 cites W2060575765 @default.
- W2109131632 cites W2062517131 @default.
- W2109131632 cites W2069922650 @default.
- W2109131632 cites W2081482233 @default.
- W2109131632 cites W2083677744 @default.
- W2109131632 cites W2103514611 @default.
- W2109131632 cites W2109140840 @default.
- W2109131632 cites W2122472025 @default.
- W2109131632 cites W2147988536 @default.
- W2109131632 cites W2156220037 @default.
- W2109131632 cites W2157407871 @default.
- W2109131632 cites W2158603760 @default.
- W2109131632 cites W2160442878 @default.
- W2109131632 cites W4236932840 @default.
- W2109131632 cites W4293052689 @default.
- W2109131632 doi "https://doi.org/10.1111/j.1368-5031.2006.00970.x" @default.
- W2109131632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16805746" @default.
- W2109131632 hasPublicationYear "2006" @default.
- W2109131632 type Work @default.
- W2109131632 sameAs 2109131632 @default.
- W2109131632 citedByCount "17" @default.
- W2109131632 countsByYear W21091316322014 @default.
- W2109131632 countsByYear W21091316322015 @default.
- W2109131632 countsByYear W21091316322018 @default.
- W2109131632 countsByYear W21091316322020 @default.
- W2109131632 countsByYear W21091316322021 @default.
- W2109131632 crossrefType "journal-article" @default.
- W2109131632 hasAuthorship W2109131632A5001570809 @default.
- W2109131632 hasAuthorship W2109131632A5007703609 @default.
- W2109131632 hasAuthorship W2109131632A5022527154 @default.
- W2109131632 hasAuthorship W2109131632A5029474399 @default.
- W2109131632 hasAuthorship W2109131632A5031115157 @default.
- W2109131632 hasAuthorship W2109131632A5050708922 @default.
- W2109131632 hasAuthorship W2109131632A5062227574 @default.
- W2109131632 hasBestOaLocation W21091316321 @default.
- W2109131632 hasConcept C118552586 @default.
- W2109131632 hasConcept C126322002 @default.
- W2109131632 hasConcept C139719470 @default.
- W2109131632 hasConcept C162324750 @default.
- W2109131632 hasConcept C169900460 @default.
- W2109131632 hasConcept C2776332859 @default.
- W2109131632 hasConcept C2776656118 @default.
- W2109131632 hasConcept C2776867660 @default.
- W2109131632 hasConcept C2778715236 @default.
- W2109131632 hasConcept C2779134260 @default.
- W2109131632 hasConcept C2779483572 @default.
- W2109131632 hasConcept C2780904820 @default.
- W2109131632 hasConcept C2984915365 @default.
- W2109131632 hasConcept C71924100 @default.
- W2109131632 hasConcept C72563966 @default.
- W2109131632 hasConcept C79544238 @default.
- W2109131632 hasConceptScore W2109131632C118552586 @default.
- W2109131632 hasConceptScore W2109131632C126322002 @default.
- W2109131632 hasConceptScore W2109131632C139719470 @default.
- W2109131632 hasConceptScore W2109131632C162324750 @default.
- W2109131632 hasConceptScore W2109131632C169900460 @default.
- W2109131632 hasConceptScore W2109131632C2776332859 @default.
- W2109131632 hasConceptScore W2109131632C2776656118 @default.
- W2109131632 hasConceptScore W2109131632C2776867660 @default.
- W2109131632 hasConceptScore W2109131632C2778715236 @default.
- W2109131632 hasConceptScore W2109131632C2779134260 @default.
- W2109131632 hasConceptScore W2109131632C2779483572 @default.
- W2109131632 hasConceptScore W2109131632C2780904820 @default.
- W2109131632 hasConceptScore W2109131632C2984915365 @default.
- W2109131632 hasConceptScore W2109131632C71924100 @default.
- W2109131632 hasConceptScore W2109131632C72563966 @default.
- W2109131632 hasConceptScore W2109131632C79544238 @default.
- W2109131632 hasIssue "6" @default.
- W2109131632 hasLocation W21091316321 @default.
- W2109131632 hasLocation W21091316322 @default.
- W2109131632 hasLocation W21091316323 @default.
- W2109131632 hasOpenAccess W2109131632 @default.