FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109133691> ?p ?o ?g. }

• W2109133691 endingPage "2079" @default.
• W2109133691 startingPage "2062" @default.
• W2109133691 abstract "Abstract FSH is produced by the pituitary gonadotrope to regulate gametogenesis. Steroid hormones, including androgens, progestins, and glucocorticoids, have all been shown to stimulate expression of the FSHβ subunit in primary pituitary cells and rodent models. Understanding the molecular mechanisms of steroid induction of FSHβ has been difficult due to the heterogeneity of the anterior pituitary. Immortalized LβT2 cells are a model of a mature gonadotrope cell and express the endogenous steroid receptor for each of the three hormones. Transient transfection of each receptor, along with ligand treatment, stimulates the mouse FSHβ promoter, but induction is severely diminished using receptors that lack the ability to bind DNA, indicating that induction is likely through direct DNA binding. All three steroid hormones act within the first 500 bp of the FSHβ promoter where six putative hormone response elements exist. The −381 site is critical for FSHβ induction by all three steroid hormones, whereas the −197 and −139 sites contribute to maximal induction. Interestingly, the −273 and −230 sites are also necessary for androgen and progestin induction of FSHβ, but not for glucocorticoid induction. Additionally, we find that all three receptors bind the endogenous FSHβ promoter, in vivo, and specifically bind the −381 site in vitro, suggesting that the binding of the receptors to this element is critical for the induction of FSHβ by these 3-keto steroid hormones. Our data indicate that androgens, glucocorticoids, and progestins act via their receptors to directly activate FSHβ gene expression in the pituitary gonadotrope." @default.
• W2109133691 created "2016-06-24" @default.
• W2109133691 creator A5014316757 @default.
• W2109133691 creator A5042178162 @default.
• W2109133691 creator A5050968979 @default.
• W2109133691 date "2006-09-01" @default.
• W2109133691 modified "2023-10-13" @default.
• W2109133691 title "Androgens, Progestins, and Glucocorticoids Induce Follicle-Stimulating Hormone β-Subunit Gene Expression at the Level of the Gonadotrope" @default.
• W2109133691 cites W1551136566 @default.
• W2109133691 cites W1966007046 @default.
• W2109133691 cites W1967174959 @default.
• W2109133691 cites W1970973631 @default.
• W2109133691 cites W1971322762 @default.
• W2109133691 cites W1971410321 @default.
• W2109133691 cites W1973113277 @default.
• W2109133691 cites W1976676739 @default.
• W2109133691 cites W1976983409 @default.
• W2109133691 cites W1977357672 @default.
• W2109133691 cites W1977423388 @default.
• W2109133691 cites W1977748889 @default.
• W2109133691 cites W1977833507 @default.
• W2109133691 cites W1979419333 @default.
• W2109133691 cites W1979576412 @default.
• W2109133691 cites W1989478369 @default.
• W2109133691 cites W1992013972 @default.
• W2109133691 cites W1994665476 @default.
• W2109133691 cites W1997510672 @default.
• W2109133691 cites W2001278188 @default.
• W2109133691 cites W2001830316 @default.
• W2109133691 cites W2003266245 @default.
• W2109133691 cites W2003345409 @default.
• W2109133691 cites W2006585554 @default.
• W2109133691 cites W2006890864 @default.
• W2109133691 cites W2008742762 @default.
• W2109133691 cites W2011585740 @default.
• W2109133691 cites W2019251281 @default.
• W2109133691 cites W2020709023 @default.
• W2109133691 cites W2024584207 @default.
• W2109133691 cites W2026276408 @default.
• W2109133691 cites W2026709466 @default.
• W2109133691 cites W2029800597 @default.
• W2109133691 cites W2030914006 @default.
• W2109133691 cites W2031192188 @default.
• W2109133691 cites W2031551813 @default.
• W2109133691 cites W2034011053 @default.
• W2109133691 cites W2035000884 @default.
• W2109133691 cites W2036509369 @default.
• W2109133691 cites W2042617707 @default.
• W2109133691 cites W2045206677 @default.
• W2109133691 cites W2047102749 @default.
• W2109133691 cites W2049971061 @default.
• W2109133691 cites W2052341629 @default.
• W2109133691 cites W2059086045 @default.
• W2109133691 cites W2060903877 @default.
• W2109133691 cites W2062997715 @default.
• W2109133691 cites W2063645101 @default.
• W2109133691 cites W2064224644 @default.
• W2109133691 cites W2064348906 @default.
• W2109133691 cites W2064894676 @default.
• W2109133691 cites W2065053313 @default.
• W2109133691 cites W2066951718 @default.
• W2109133691 cites W2071792035 @default.
• W2109133691 cites W2072551067 @default.
• W2109133691 cites W2081443590 @default.
• W2109133691 cites W2084287421 @default.
• W2109133691 cites W2085403222 @default.
• W2109133691 cites W2092224562 @default.
• W2109133691 cites W2097210020 @default.
• W2109133691 cites W2105698692 @default.
• W2109133691 cites W2107757798 @default.
• W2109133691 cites W2109218990 @default.
• W2109133691 cites W2109393054 @default.
• W2109133691 cites W2111286539 @default.
• W2109133691 cites W2112912949 @default.
• W2109133691 cites W2115738815 @default.
• W2109133691 cites W2116553172 @default.
• W2109133691 cites W2124518271 @default.
• W2109133691 cites W2126362486 @default.
• W2109133691 cites W2128103152 @default.
• W2109133691 cites W2128840922 @default.
• W2109133691 cites W2131226468 @default.
• W2109133691 cites W2133777142 @default.
• W2109133691 cites W2134976758 @default.
• W2109133691 cites W2137676124 @default.
• W2109133691 cites W2138232622 @default.
• W2109133691 cites W2144075249 @default.
• W2109133691 cites W2144451311 @default.
• W2109133691 cites W2153947307 @default.
• W2109133691 cites W2164695122 @default.
• W2109133691 cites W2165580513 @default.
• W2109133691 cites W2172256092 @default.
• W2109133691 cites W230394473 @default.
• W2109133691 cites W2412490099 @default.
• W2109133691 cites W2073078212 @default.
• W2109133691 doi "https://doi.org/10.1210/me.2005-0316" @default.
• W2109133691 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2941439" @default.
• W2109133691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16675544" @default.
• W2109133691 hasPublicationYear "2006" @default.

• next