FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109134094> ?p ?o ?g. }

• W2109134094 endingPage "R26" @default.
• W2109134094 startingPage "R26" @default.
• W2109134094 abstract "This study investigated whether the calcineurin inhibitor, tacrolimus, suppresses receptor activator of NF-κB ligand (RANKL) expression in fibroblast-like synoviocytes (FLS) through regulation of IL-6/Janus activated kinase (JAK2)/signal transducer and activator of transcription-3 (STAT3) and suppressor of cytokine signaling (SOCS3) signaling.The expression of RANKL, JAK2, STAT3, and SOCS3 proteins was assessed by western blot analysis, real-time PCR and ELISA in IL-6 combined with soluble IL-6 receptor (sIL-6R)-stimulated rheumatoid arthritis (RA)-FLS with or without tacrolimus treatment. The effects of tacrolimus on synovial inflammation and bone erosion were assessed using mice with arthritis induced by K/BxN serum. Immunofluorescent staining was performed to identify the effect of tacrolimus on RANKL and SOCS3. The tartrate-resistant acid phosphatase staining assay was performed to assess the effect of tacrolimus on osteoclast differentiation.We found that RANKL expression in RA FLS is regulated by the IL-6/sIL-6R/JAK2/STAT3/SOCS3 pathway. Inhibitory effects of tacrolimus on RANKL expression in a serum-induced arthritis mice model were identified. Tacrolimus inhibits RANKL expression in IL-6/sIL-6R-stimulated FLS by suppressing STAT3. Among negative regulators of the JAK/STAT pathway, such as CIS1, SOCS1, and SOCS3, only SOCS3 is significantly induced by tacrolimus. As compared to dexamethasone and methotrexate, tacrolimus more potently suppresses RANKL expression in FLS. By up-regulating SOCS3, tacrolimus down-regulates activation of the JAK-STAT pathway by IL-6/sIL-6R trans-signaling, thus decreasing RANKL expression in FLS.These data suggest that tacrolimus might affect the RANKL expression in IL-6 stimulated FLS through STAT3 suppression, together with up-regulation of SOCS3." @default.
• W2109134094 created "2016-06-24" @default.
• W2109134094 creator A5022994723 @default.
• W2109134094 creator A5047222469 @default.
• W2109134094 creator A5050458041 @default.
• W2109134094 creator A5077581043 @default.
• W2109134094 creator A5087845668 @default.
• W2109134094 date "2013-01-01" @default.
• W2109134094 modified "2023-10-07" @default.
• W2109134094 title "Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes" @default.
• W2109134094 cites W1969708241 @default.
• W2109134094 cites W1972363513 @default.
• W2109134094 cites W1989607165 @default.
• W2109134094 cites W1995997868 @default.
• W2109134094 cites W1997581290 @default.
• W2109134094 cites W1998103686 @default.
• W2109134094 cites W2000583211 @default.
• W2109134094 cites W2003208357 @default.
• W2109134094 cites W2003287175 @default.
• W2109134094 cites W2024293017 @default.
• W2109134094 cites W2035636765 @default.
• W2109134094 cites W2044219199 @default.
• W2109134094 cites W2046899826 @default.
• W2109134094 cites W2074885296 @default.
• W2109134094 cites W2088942316 @default.
• W2109134094 cites W2114335223 @default.
• W2109134094 cites W2127938598 @default.
• W2109134094 cites W2138784254 @default.
• W2109134094 cites W2139996507 @default.
• W2109134094 cites W2148172224 @default.
• W2109134094 cites W2152348310 @default.
• W2109134094 cites W2153869151 @default.
• W2109134094 doi "https://doi.org/10.1186/ar4162" @default.
• W2109134094 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3672788" @default.
• W2109134094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23406906" @default.
• W2109134094 hasPublicationYear "2013" @default.
• W2109134094 type Work @default.
• W2109134094 sameAs 2109134094 @default.
• W2109134094 citedByCount "39" @default.
• W2109134094 countsByYear W21091340942013 @default.
• W2109134094 countsByYear W21091340942014 @default.
• W2109134094 countsByYear W21091340942015 @default.
• W2109134094 countsByYear W21091340942016 @default.
• W2109134094 countsByYear W21091340942017 @default.
• W2109134094 countsByYear W21091340942018 @default.
• W2109134094 countsByYear W21091340942019 @default.
• W2109134094 countsByYear W21091340942020 @default.
• W2109134094 countsByYear W21091340942021 @default.
• W2109134094 countsByYear W21091340942022 @default.
• W2109134094 crossrefType "journal-article" @default.
• W2109134094 hasAuthorship W2109134094A5022994723 @default.
• W2109134094 hasAuthorship W2109134094A5047222469 @default.
• W2109134094 hasAuthorship W2109134094A5050458041 @default.
• W2109134094 hasAuthorship W2109134094A5077581043 @default.
• W2109134094 hasAuthorship W2109134094A5087845668 @default.
• W2109134094 hasBestOaLocation W21091340941 @default.
• W2109134094 hasConcept C112392421 @default.
• W2109134094 hasConcept C126042315 @default.
• W2109134094 hasConcept C126322002 @default.
• W2109134094 hasConcept C128057223 @default.
• W2109134094 hasConcept C170493617 @default.
• W2109134094 hasConcept C185592680 @default.
• W2109134094 hasConcept C2778923194 @default.
• W2109134094 hasConcept C2779428903 @default.
• W2109134094 hasConcept C2909675724 @default.
• W2109134094 hasConcept C2911091166 @default.
• W2109134094 hasConcept C502942594 @default.
• W2109134094 hasConcept C55493867 @default.
• W2109134094 hasConcept C62478195 @default.
• W2109134094 hasConcept C71924100 @default.
• W2109134094 hasConcept C88045685 @default.
• W2109134094 hasConcept C98274493 @default.
• W2109134094 hasConceptScore W2109134094C112392421 @default.
• W2109134094 hasConceptScore W2109134094C126042315 @default.
• W2109134094 hasConceptScore W2109134094C126322002 @default.
• W2109134094 hasConceptScore W2109134094C128057223 @default.
• W2109134094 hasConceptScore W2109134094C170493617 @default.
• W2109134094 hasConceptScore W2109134094C185592680 @default.
• W2109134094 hasConceptScore W2109134094C2778923194 @default.
• W2109134094 hasConceptScore W2109134094C2779428903 @default.
• W2109134094 hasConceptScore W2109134094C2909675724 @default.
• W2109134094 hasConceptScore W2109134094C2911091166 @default.
• W2109134094 hasConceptScore W2109134094C502942594 @default.
• W2109134094 hasConceptScore W2109134094C55493867 @default.
• W2109134094 hasConceptScore W2109134094C62478195 @default.
• W2109134094 hasConceptScore W2109134094C71924100 @default.
• W2109134094 hasConceptScore W2109134094C88045685 @default.
• W2109134094 hasConceptScore W2109134094C98274493 @default.
• W2109134094 hasIssue "1" @default.
• W2109134094 hasLocation W21091340941 @default.
• W2109134094 hasLocation W21091340942 @default.
• W2109134094 hasLocation W21091340943 @default.
• W2109134094 hasLocation W21091340944 @default.
• W2109134094 hasOpenAccess W2109134094 @default.
• W2109134094 hasPrimaryLocation W21091340941 @default.
• W2109134094 hasRelatedWork W1740603564 @default.
• W2109134094 hasRelatedWork W1990611714 @default.
• W2109134094 hasRelatedWork W2023805676 @default.

• next