Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109136976> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2109136976 endingPage "2515" @default.
- W2109136976 startingPage "2510" @default.
- W2109136976 abstract "Background The relation between early afterdepolarizations (EADs) and changes in intracellular Ca 2+ concentration ([Ca 2+ ] i ) is still unclear. In the present study, we compared spatiotemporal changes in [Ca 2+ ] i related to EADs and delayed afterdepolarizations (DADs) induced by isoproterenol. Methods and Results Isolated patch-clamped guinea pig ventricular myocytes, loaded with fluo-3 acetoxymethyl ester (fluo-3 AM), were paced at 0.1 to 2 Hz. Isoproterenol (100 nmol/L) caused alterations in both phase 2 and phase 4 of the action potential (AP), consistent with EADs and DADs, respectively. During EADs (n=16), similar to driven APs, increases in [Ca 2+ ] i occurred simultaneously throughout the cell, whereas during DADs (n=25), they originated in discrete cell sites and propagated as a wave. This difference was confirmed by analysis of eight EADs and DADs coupled to the same beat. Ca 2+ transients linked to EADs reached a peak relative fluorescence level (expressed as percentage of the maximal level reached during the last stimulated beat) that was always higher than that reached during the DADs (77±3% versus 64±2%, P <.001). Spatial heterogeneity of Ca 2+ transients was assessed by the maximal time interval between peaks monitored in different cell regions; this time lag was always greater during DADs than during EADs (290 versus 40 milliseconds, P =.006). Conclusions The present study had two main findings. First, even very modest notches occurring during the plateau of the AP may be accompanied by a marked secondary increase in [Ca 2+ ] i . Second, these Ca 2+ transients occurring during EADs are synchronous throughout the cell and differ significantly from those observed under identical conditions during DADs." @default.
- W2109136976 created "2016-06-24" @default.
- W2109136976 creator A5012299878 @default.
- W2109136976 creator A5048981444 @default.
- W2109136976 creator A5051326866 @default.
- W2109136976 creator A5073175559 @default.
- W2109136976 creator A5080214191 @default.
- W2109136976 date "1995-05-15" @default.
- W2109136976 modified "2023-09-26" @default.
- W2109136976 title "Distinct Patterns of Calcium Transients During Early and Delayed Afterdepolarizations Induced by Isoproterenol in Ventricular Myocytes" @default.
- W2109136976 cites W1506088182 @default.
- W2109136976 cites W1601936385 @default.
- W2109136976 cites W2048652590 @default.
- W2109136976 cites W2050607977 @default.
- W2109136976 cites W2070128271 @default.
- W2109136976 cites W2070207428 @default.
- W2109136976 cites W2075793586 @default.
- W2109136976 cites W2138945495 @default.
- W2109136976 cites W2148308576 @default.
- W2109136976 cites W40325564 @default.
- W2109136976 doi "https://doi.org/10.1161/01.cir.91.10.2510" @default.
- W2109136976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7743611" @default.
- W2109136976 hasPublicationYear "1995" @default.
- W2109136976 type Work @default.
- W2109136976 sameAs 2109136976 @default.
- W2109136976 citedByCount "55" @default.
- W2109136976 countsByYear W21091369762012 @default.
- W2109136976 countsByYear W21091369762013 @default.
- W2109136976 countsByYear W21091369762014 @default.
- W2109136976 countsByYear W21091369762015 @default.
- W2109136976 countsByYear W21091369762016 @default.
- W2109136976 countsByYear W21091369762018 @default.
- W2109136976 countsByYear W21091369762020 @default.
- W2109136976 crossrefType "journal-article" @default.
- W2109136976 hasAuthorship W2109136976A5012299878 @default.
- W2109136976 hasAuthorship W2109136976A5048981444 @default.
- W2109136976 hasAuthorship W2109136976A5051326866 @default.
- W2109136976 hasAuthorship W2109136976A5073175559 @default.
- W2109136976 hasAuthorship W2109136976A5080214191 @default.
- W2109136976 hasConcept C121332964 @default.
- W2109136976 hasConcept C12554922 @default.
- W2109136976 hasConcept C126322002 @default.
- W2109136976 hasConcept C134018914 @default.
- W2109136976 hasConcept C146403970 @default.
- W2109136976 hasConcept C155730078 @default.
- W2109136976 hasConcept C185263204 @default.
- W2109136976 hasConcept C185592680 @default.
- W2109136976 hasConcept C189809214 @default.
- W2109136976 hasConcept C207200792 @default.
- W2109136976 hasConcept C24890656 @default.
- W2109136976 hasConcept C519063684 @default.
- W2109136976 hasConcept C55493867 @default.
- W2109136976 hasConcept C71924100 @default.
- W2109136976 hasConcept C79879829 @default.
- W2109136976 hasConcept C86803240 @default.
- W2109136976 hasConceptScore W2109136976C121332964 @default.
- W2109136976 hasConceptScore W2109136976C12554922 @default.
- W2109136976 hasConceptScore W2109136976C126322002 @default.
- W2109136976 hasConceptScore W2109136976C134018914 @default.
- W2109136976 hasConceptScore W2109136976C146403970 @default.
- W2109136976 hasConceptScore W2109136976C155730078 @default.
- W2109136976 hasConceptScore W2109136976C185263204 @default.
- W2109136976 hasConceptScore W2109136976C185592680 @default.
- W2109136976 hasConceptScore W2109136976C189809214 @default.
- W2109136976 hasConceptScore W2109136976C207200792 @default.
- W2109136976 hasConceptScore W2109136976C24890656 @default.
- W2109136976 hasConceptScore W2109136976C519063684 @default.
- W2109136976 hasConceptScore W2109136976C55493867 @default.
- W2109136976 hasConceptScore W2109136976C71924100 @default.
- W2109136976 hasConceptScore W2109136976C79879829 @default.
- W2109136976 hasConceptScore W2109136976C86803240 @default.
- W2109136976 hasIssue "10" @default.
- W2109136976 hasLocation W21091369761 @default.
- W2109136976 hasLocation W21091369762 @default.
- W2109136976 hasOpenAccess W2109136976 @default.
- W2109136976 hasPrimaryLocation W21091369761 @default.
- W2109136976 hasRelatedWork W111279135 @default.
- W2109136976 hasRelatedWork W1981642108 @default.
- W2109136976 hasRelatedWork W2003842308 @default.
- W2109136976 hasRelatedWork W2010740725 @default.
- W2109136976 hasRelatedWork W2064236298 @default.
- W2109136976 hasRelatedWork W2095093072 @default.
- W2109136976 hasRelatedWork W2337785167 @default.
- W2109136976 hasRelatedWork W2384457103 @default.
- W2109136976 hasRelatedWork W2748952813 @default.
- W2109136976 hasRelatedWork W3151887034 @default.
- W2109136976 hasVolume "91" @default.
- W2109136976 isParatext "false" @default.
- W2109136976 isRetracted "false" @default.
- W2109136976 magId "2109136976" @default.
- W2109136976 workType "article" @default.