FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109137601> ?p ?o ?g. }

• W2109137601 endingPage "183" @default.
• W2109137601 startingPage "175" @default.
• W2109137601 abstract "Loss of expression of the type III transforming growth factor-beta receptor (TbetaRIII or betaglycan), a transforming growth factor-beta (TGF-beta) superfamily co-receptor, is common in human breast cancers. TbetaRIII suppresses cancer progression in vivo by reducing cancer cell migration and invasion by largely unknown mechanisms. Here, we demonstrate that the cytoplasmic domain of TbetaRIII is essential for TbetaRIII-mediated downregulation of migration and invasion in vitro and TbetaRIII-mediated inhibition of breast cancer progression in vivo. Functionally, the cytoplasmic domain of TbetaRIII is required to attenuate TGF-beta signaling, whereas TbetaRIII-mediated attenuation of TGF-beta signaling is required for TbetaRIII-mediated inhibition of migration and invasion. Mechanistically, both TbetaRIII-mediated inhibition of TGF-beta signaling and TbetaRIII-mediated inhibition of invasion occur through the interaction of the cytoplasmic domain of TbetaRIII with the scaffolding protein GAIP-interacting protein C-terminus (GIPC). Taken together, these studies support a functional role for the TbetaRIII cytoplasmic domain interacting with GIPC to suppress breast cancer progression." @default.
• W2109137601 created "2016-06-24" @default.
• W2109137601 creator A5012601024 @default.
• W2109137601 creator A5024845751 @default.
• W2109137601 creator A5029870390 @default.
• W2109137601 creator A5059740024 @default.
• W2109137601 date "2009-12-02" @default.
• W2109137601 modified "2023-10-14" @default.
• W2109137601 title "The type III TGF-β receptor suppresses breast cancer progression through GIPC-mediated inhibition of TGF-β signaling" @default.
• W2109137601 cites W1969619516 @default.
• W2109137601 cites W1981803039 @default.
• W2109137601 cites W1984495187 @default.
• W2109137601 cites W1987148584 @default.
• W2109137601 cites W1993108215 @default.
• W2109137601 cites W1997508119 @default.
• W2109137601 cites W2030715184 @default.
• W2109137601 cites W2036148210 @default.
• W2109137601 cites W2049530394 @default.
• W2109137601 cites W2067875575 @default.
• W2109137601 cites W2079189474 @default.
• W2109137601 cites W2088721663 @default.
• W2109137601 cites W2092404030 @default.
• W2109137601 cites W2103031848 @default.
• W2109137601 cites W2111949892 @default.
• W2109137601 cites W2118456764 @default.
• W2109137601 cites W2119593390 @default.
• W2109137601 cites W2131597845 @default.
• W2109137601 cites W2138411138 @default.
• W2109137601 cites W2146078790 @default.
• W2109137601 cites W2150091603 @default.
• W2109137601 cites W2156022038 @default.
• W2109137601 cites W2156581465 @default.
• W2109137601 cites W2170563954 @default.
• W2109137601 cites W2316067769 @default.
• W2109137601 doi "https://doi.org/10.1093/carcin/bgp271" @default.
• W2109137601 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2812570" @default.
• W2109137601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19955393" @default.
• W2109137601 hasPublicationYear "2009" @default.
• W2109137601 type Work @default.
• W2109137601 sameAs 2109137601 @default.
• W2109137601 citedByCount "53" @default.
• W2109137601 countsByYear W21091376012012 @default.
• W2109137601 countsByYear W21091376012013 @default.
• W2109137601 countsByYear W21091376012014 @default.
• W2109137601 countsByYear W21091376012015 @default.
• W2109137601 countsByYear W21091376012016 @default.
• W2109137601 countsByYear W21091376012017 @default.
• W2109137601 countsByYear W21091376012018 @default.
• W2109137601 countsByYear W21091376012019 @default.
• W2109137601 countsByYear W21091376012020 @default.
• W2109137601 countsByYear W21091376012021 @default.
• W2109137601 countsByYear W21091376012022 @default.
• W2109137601 countsByYear W21091376012023 @default.
• W2109137601 crossrefType "journal-article" @default.
• W2109137601 hasAuthorship W2109137601A5012601024 @default.
• W2109137601 hasAuthorship W2109137601A5024845751 @default.
• W2109137601 hasAuthorship W2109137601A5029870390 @default.
• W2109137601 hasAuthorship W2109137601A5059740024 @default.
• W2109137601 hasBestOaLocation W21091376012 @default.
• W2109137601 hasConcept C104317684 @default.
• W2109137601 hasConcept C111001777 @default.
• W2109137601 hasConcept C118131993 @default.
• W2109137601 hasConcept C121608353 @default.
• W2109137601 hasConcept C126322002 @default.
• W2109137601 hasConcept C127561419 @default.
• W2109137601 hasConcept C137738243 @default.
• W2109137601 hasConcept C1491633281 @default.
• W2109137601 hasConcept C170493617 @default.
• W2109137601 hasConcept C190062978 @default.
• W2109137601 hasConcept C2778229498 @default.
• W2109137601 hasConcept C2779256057 @default.
• W2109137601 hasConcept C502942594 @default.
• W2109137601 hasConcept C53645450 @default.
• W2109137601 hasConcept C55493867 @default.
• W2109137601 hasConcept C62112901 @default.
• W2109137601 hasConcept C62478195 @default.
• W2109137601 hasConcept C71924100 @default.
• W2109137601 hasConcept C86803240 @default.
• W2109137601 hasConcept C95444343 @default.
• W2109137601 hasConceptScore W2109137601C104317684 @default.
• W2109137601 hasConceptScore W2109137601C111001777 @default.
• W2109137601 hasConceptScore W2109137601C118131993 @default.
• W2109137601 hasConceptScore W2109137601C121608353 @default.
• W2109137601 hasConceptScore W2109137601C126322002 @default.
• W2109137601 hasConceptScore W2109137601C127561419 @default.
• W2109137601 hasConceptScore W2109137601C137738243 @default.
• W2109137601 hasConceptScore W2109137601C1491633281 @default.
• W2109137601 hasConceptScore W2109137601C170493617 @default.
• W2109137601 hasConceptScore W2109137601C190062978 @default.
• W2109137601 hasConceptScore W2109137601C2778229498 @default.
• W2109137601 hasConceptScore W2109137601C2779256057 @default.
• W2109137601 hasConceptScore W2109137601C502942594 @default.
• W2109137601 hasConceptScore W2109137601C53645450 @default.
• W2109137601 hasConceptScore W2109137601C55493867 @default.
• W2109137601 hasConceptScore W2109137601C62112901 @default.
• W2109137601 hasConceptScore W2109137601C62478195 @default.
• W2109137601 hasConceptScore W2109137601C71924100 @default.
• W2109137601 hasConceptScore W2109137601C86803240 @default.

• next