Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109142485> ?p ?o ?g. }
- W2109142485 endingPage "8" @default.
- W2109142485 startingPage "1" @default.
- W2109142485 abstract "The primary functional abnormality in asthma is airway hyperresponsiveness (AHR)-excessive airway narrowing to bronchoconstrictor stimuli. Our understanding of the underlying mechanism(s) producing AHR is incomplete. While structure-function relationships have been evoked to explain AHR (e.g., increased airway smooth muscle (ASM) mass in asthma) more recently there has been a focus on how the dynamic mechanical environment of the lung impacts airway responsiveness in health and disease. The effects of breathing movements such as deep inspiration reveal innate protective mechanisms in healthy individuals that are likely mediated by dynamic ASM stretch but which may be impaired in asthmatic patients and thereby facilitate AHR. This perspective considers the evidence for and against a role of dynamic ASM stretch in limiting the capacity of airways to narrow excessively. We propose that lung function measured after bronchial provocation in the laboratory and changes in lung function perceived by the patient in everyday life may be quite different in their dependence on dynamic ASM stretch." @default.
- W2109142485 created "2016-06-24" @default.
- W2109142485 creator A5006245077 @default.
- W2109142485 creator A5042018773 @default.
- W2109142485 creator A5068692445 @default.
- W2109142485 creator A5074160945 @default.
- W2109142485 creator A5090399601 @default.
- W2109142485 date "2012-10-17" @default.
- W2109142485 modified "2023-10-05" @default.
- W2109142485 title "Airway Smooth Muscle Dynamics and Hyperresponsiveness: In and outside the Clinic" @default.
- W2109142485 cites W1900945426 @default.
- W2109142485 cites W1915107197 @default.
- W2109142485 cites W1965683748 @default.
- W2109142485 cites W1968199450 @default.
- W2109142485 cites W1968829169 @default.
- W2109142485 cites W1972801148 @default.
- W2109142485 cites W1989260226 @default.
- W2109142485 cites W1991524561 @default.
- W2109142485 cites W1994007036 @default.
- W2109142485 cites W1997663100 @default.
- W2109142485 cites W2009067219 @default.
- W2109142485 cites W2018776138 @default.
- W2109142485 cites W2021400722 @default.
- W2109142485 cites W2023554026 @default.
- W2109142485 cites W2029466697 @default.
- W2109142485 cites W2035796389 @default.
- W2109142485 cites W2038359500 @default.
- W2109142485 cites W2043976144 @default.
- W2109142485 cites W2047545780 @default.
- W2109142485 cites W2050903584 @default.
- W2109142485 cites W2051368466 @default.
- W2109142485 cites W2053299045 @default.
- W2109142485 cites W2067558692 @default.
- W2109142485 cites W2068034080 @default.
- W2109142485 cites W2074096822 @default.
- W2109142485 cites W2074924122 @default.
- W2109142485 cites W2080296558 @default.
- W2109142485 cites W2083019591 @default.
- W2109142485 cites W2091959629 @default.
- W2109142485 cites W2096716033 @default.
- W2109142485 cites W2100144388 @default.
- W2109142485 cites W2101834528 @default.
- W2109142485 cites W2103382661 @default.
- W2109142485 cites W2103488996 @default.
- W2109142485 cites W2105767868 @default.
- W2109142485 cites W2110154021 @default.
- W2109142485 cites W2110475616 @default.
- W2109142485 cites W2116219344 @default.
- W2109142485 cites W2119455580 @default.
- W2109142485 cites W2123994460 @default.
- W2109142485 cites W2126790740 @default.
- W2109142485 cites W2131279196 @default.
- W2109142485 cites W2133864761 @default.
- W2109142485 cites W2134312563 @default.
- W2109142485 cites W2135414619 @default.
- W2109142485 cites W2137183250 @default.
- W2109142485 cites W2143932517 @default.
- W2109142485 cites W2145389220 @default.
- W2109142485 cites W2147133415 @default.
- W2109142485 cites W2147241594 @default.
- W2109142485 cites W2155854962 @default.
- W2109142485 cites W2156882067 @default.
- W2109142485 cites W2163496762 @default.
- W2109142485 cites W2165981929 @default.
- W2109142485 cites W2166734122 @default.
- W2109142485 cites W2170621629 @default.
- W2109142485 cites W2173089663 @default.
- W2109142485 cites W2173581179 @default.
- W2109142485 cites W2178187882 @default.
- W2109142485 cites W2178190895 @default.
- W2109142485 cites W2186370106 @default.
- W2109142485 cites W2227709721 @default.
- W2109142485 cites W2230717736 @default.
- W2109142485 cites W2239965405 @default.
- W2109142485 cites W2259347332 @default.
- W2109142485 cites W2263355384 @default.
- W2109142485 cites W2269913491 @default.
- W2109142485 cites W2279063440 @default.
- W2109142485 cites W2323709445 @default.
- W2109142485 cites W2413776145 @default.
- W2109142485 doi "https://doi.org/10.1155/2012/157047" @default.
- W2109142485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3483736" @default.
- W2109142485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23118774" @default.
- W2109142485 hasPublicationYear "2012" @default.
- W2109142485 type Work @default.
- W2109142485 sameAs 2109142485 @default.
- W2109142485 citedByCount "11" @default.
- W2109142485 countsByYear W21091424852013 @default.
- W2109142485 countsByYear W21091424852015 @default.
- W2109142485 countsByYear W21091424852016 @default.
- W2109142485 countsByYear W21091424852019 @default.
- W2109142485 countsByYear W21091424852020 @default.
- W2109142485 countsByYear W21091424852021 @default.
- W2109142485 crossrefType "journal-article" @default.
- W2109142485 hasAuthorship W2109142485A5006245077 @default.
- W2109142485 hasAuthorship W2109142485A5042018773 @default.
- W2109142485 hasAuthorship W2109142485A5068692445 @default.
- W2109142485 hasAuthorship W2109142485A5074160945 @default.