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• W2109142716 startingPage "2949" @default.
• W2109142716 abstract "ABSTRACT The armA ( a minoglycoside r esistance m ethylase) gene, which confers resistance to 4,6-disubstituted deoxystreptamines and fortimicin, was initially found in Klebsiella pneumoniae BM4536 on IncL/M plasmid pIP1204 of ca. 90 kb which also encodes the extended-spectrum β-lactamase CTX-M-3. Thirty-four enterobacteria from various countries that were likely to produce a CTX-M enzyme since they were more resistant to cefotaxime than to ceftazidime were studied. The armA gene was detected in 12 clinical isolates of Citrobacter freundii , Enterobacter cloacae , Escherichia coli , K. pneumoniae , Salmonella enterica , and Shigella flexneri , in which it was always associated with bla CTX-M-3 on an IncL/M plasmid. Conjugation, analysis of DNA sequences, PCR mapping, and plasmid conduction experiments indicated that the armA gene was part of composite transposon Tn 1548 together with genes ant39 , sul1 , and dfrXII , which are responsible for resistance to streptomycin-spectinomycin, sulfonamides, and trimethoprim, respectively. The 16.6-kb genetic element was flanked by two copies of IS 6 and migrated by replicative transposition. This observation accounts for the presence of armA on self-transferable plasmids of various incompatibility groups and its worldwide dissemination. It thus appears that posttranscriptional modification of 16S rRNA confers high-level resistance to all the clinically available aminoglycosides except streptomycin in gram-negative human and animal pathogens." @default.
• W2109142716 created "2016-06-24" @default.
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• W2109142716 date "2005-07-01" @default.
• W2109142716 modified "2023-09-26" @default.
• W2109142716 title "Worldwide Disseminated <i>armA</i> Aminoglycoside Resistance Methylase Gene Is Borne by Composite Transposon Tn <i>1548</i>" @default.
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• W2109142716 doi "https://doi.org/10.1128/aac.49.7.2949-2953.2005" @default.
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