FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109145711> ?p ?o ?g. }

• W2109145711 endingPage "3892" @default.
• W2109145711 startingPage "3883" @default.
• W2109145711 abstract "Androgens delay lung maturation through their action on lung fibroblasts. Knowing that testosterone is secreted by the lung epithelial-like cell line A-549, we have studied the metabolism of androgens by several human lung diploid fibroblasts cell lines. No 17-ketosteroid reductase activity was detected. In contrast, testosterone was transformed mainly into androstenedione and androstanedione with no 5 alpha-dihydrotestosterone formed, indicating the presence of 17 beta- hydroxysteroid dehydrogenase (HSD) type 2 and 5 alpha-reductase activities. The eight cell lines analyzed had either a low or high 17 beta-HSD type 2 activity level. No correlation between these levels and the sex or age stage of cells was established, but Northern blot analysis of human lung RNA samples of five adult subjects revealed very similar variations between subjects in the level of 17 beta-HSD type 2 mRNA. The 5 alpha-reductase activity had a marked substrate preference for androstenedione, the product of 17 beta-HSD type 2. When tritiated testosterone was used as substrate, only barely detectable levels of 5 alpha-dihydrotestosterone were observed by HPLC in the presence of the 17 beta-HSD type 2 inhibitor EM-919. The use of unlabeled testosterone or of the antiandrogen hydroxyflutamide demonstrated that the tritiated testosterone substrate itself had no effect on levels of 5 alpha-reduction. In fact, in these cells, 5 alpha-reductase has no significant activity on testosterone, but it further converts the product of 17 beta-HSD type 2, thus playing a role with 17 beta-HSD type 2 in androgen inactivation. Because androgens delay lung maturation and surfactant synthesis by their action on lung fibroblasts, it is of particular interest to find that the steroid metabolism of these lung fibroblast cells is oriented toward androgen inactivation. Because lung fibroblasts of subjects with low 17 beta-HSD type 2 expression levels are likely to be exposed to higher levels of androgens, an allelic variation of the 17 beta-HSD-2 gene is suspected, which would result in familial incidence of respiratory distress. This is in line with reported cases of familial incidence of respiratory distress." @default.
• W2109145711 created "2016-06-24" @default.
• W2109145711 creator A5013191249 @default.
• W2109145711 creator A5045412833 @default.
• W2109145711 creator A5047247088 @default.
• W2109145711 creator A5047482233 @default.
• W2109145711 creator A5056212054 @default.
• W2109145711 date "2002-08-01" @default.
• W2109145711 modified "2023-09-28" @default.
• W2109145711 title "Androgen Inactivation in Human Lung Fibroblasts: Variations in Levels of 17β-Hydroxysteroid Dehydrogenase Type 2 and 5α-Reductase Activity Compatible with Androgen Inactivation" @default.
• W2109145711 cites W1106257837 @default.
• W2109145711 cites W1965096256 @default.
• W2109145711 cites W1968654392 @default.
• W2109145711 cites W1969308350 @default.
• W2109145711 cites W1998438487 @default.
• W2109145711 cites W2007530251 @default.
• W2109145711 cites W2008866655 @default.
• W2109145711 cites W2014669590 @default.
• W2109145711 cites W2020259519 @default.
• W2109145711 cites W2021144709 @default.
• W2109145711 cites W2022065845 @default.
• W2109145711 cites W2023513664 @default.
• W2109145711 cites W2030105483 @default.
• W2109145711 cites W2035924476 @default.
• W2109145711 cites W2048149426 @default.
• W2109145711 cites W2048862863 @default.
• W2109145711 cites W2058387263 @default.
• W2109145711 cites W2066097155 @default.
• W2109145711 cites W2066450488 @default.
• W2109145711 cites W2079611953 @default.
• W2109145711 cites W2081679182 @default.
• W2109145711 cites W2083116243 @default.
• W2109145711 cites W2106626882 @default.
• W2109145711 cites W2151013964 @default.
• W2109145711 cites W2153108328 @default.
• W2109145711 cites W4241531133 @default.
• W2109145711 cites W4246234200 @default.
• W2109145711 doi "https://doi.org/10.1210/jcem.87.8.8764" @default.
• W2109145711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12161528" @default.
• W2109145711 hasPublicationYear "2002" @default.
• W2109145711 type Work @default.
• W2109145711 sameAs 2109145711 @default.
• W2109145711 citedByCount "18" @default.
• W2109145711 countsByYear W21091457112013 @default.
• W2109145711 countsByYear W21091457112015 @default.
• W2109145711 countsByYear W21091457112017 @default.
• W2109145711 countsByYear W21091457112020 @default.
• W2109145711 countsByYear W21091457112021 @default.
• W2109145711 countsByYear W21091457112022 @default.
• W2109145711 countsByYear W21091457112023 @default.
• W2109145711 crossrefType "journal-article" @default.
• W2109145711 hasAuthorship W2109145711A5013191249 @default.
• W2109145711 hasAuthorship W2109145711A5045412833 @default.
• W2109145711 hasAuthorship W2109145711A5047247088 @default.
• W2109145711 hasAuthorship W2109145711A5047482233 @default.
• W2109145711 hasAuthorship W2109145711A5056212054 @default.
• W2109145711 hasBestOaLocation W21091457111 @default.
• W2109145711 hasConcept C126322002 @default.
• W2109145711 hasConcept C134018914 @default.
• W2109145711 hasConcept C134651460 @default.
• W2109145711 hasConcept C181199279 @default.
• W2109145711 hasConcept C185592680 @default.
• W2109145711 hasConcept C2776317432 @default.
• W2109145711 hasConcept C2776683971 @default.
• W2109145711 hasConcept C2777714996 @default.
• W2109145711 hasConcept C2777911890 @default.
• W2109145711 hasConcept C2779279991 @default.
• W2109145711 hasConcept C2779881493 @default.
• W2109145711 hasConcept C2781067048 @default.
• W2109145711 hasConcept C54355233 @default.
• W2109145711 hasConcept C55493867 @default.
• W2109145711 hasConcept C71315377 @default.
• W2109145711 hasConcept C71924100 @default.
• W2109145711 hasConcept C81885089 @default.
• W2109145711 hasConcept C86803240 @default.
• W2109145711 hasConceptScore W2109145711C126322002 @default.
• W2109145711 hasConceptScore W2109145711C134018914 @default.
• W2109145711 hasConceptScore W2109145711C134651460 @default.
• W2109145711 hasConceptScore W2109145711C181199279 @default.
• W2109145711 hasConceptScore W2109145711C185592680 @default.
• W2109145711 hasConceptScore W2109145711C2776317432 @default.
• W2109145711 hasConceptScore W2109145711C2776683971 @default.
• W2109145711 hasConceptScore W2109145711C2777714996 @default.
• W2109145711 hasConceptScore W2109145711C2777911890 @default.
• W2109145711 hasConceptScore W2109145711C2779279991 @default.
• W2109145711 hasConceptScore W2109145711C2779881493 @default.
• W2109145711 hasConceptScore W2109145711C2781067048 @default.
• W2109145711 hasConceptScore W2109145711C54355233 @default.
• W2109145711 hasConceptScore W2109145711C55493867 @default.
• W2109145711 hasConceptScore W2109145711C71315377 @default.
• W2109145711 hasConceptScore W2109145711C71924100 @default.
• W2109145711 hasConceptScore W2109145711C81885089 @default.
• W2109145711 hasConceptScore W2109145711C86803240 @default.
• W2109145711 hasIssue "8" @default.
• W2109145711 hasLocation W21091457111 @default.
• W2109145711 hasLocation W21091457112 @default.
• W2109145711 hasOpenAccess W2109145711 @default.
• W2109145711 hasPrimaryLocation W21091457111 @default.

• next