FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109145958> ?p ?o ?g. }

• W2109145958 endingPage "2539" @default.
• W2109145958 startingPage "2529" @default.
• W2109145958 abstract "We examined spindle elongation in anaphase in Saccharomyces cerevisiae cells mutated for the kinesin-5 motor proteins Cin8 and Kip1. Cells were deleted for KIP1 and/or expressed one of two motor-domain Cin8 mutants (Cin8-F467A or Cin8-R196K, which differ in their ability to bind microtubules in vitro, with Cin8-F467A having the weakest ability). We found that, in kinesin-5-mutated cells, predominantly in kip1Δ cin8-F467A cells, anaphase spindle elongation was frequently interrupted after the fast phase, resulting in a mid-anaphase pause. Expression of kinesin-5 mutants also caused an asymmetric midzone location and enlarged midzone size, suggesting that proper organization of the midzone is required for continuous spindle elongation. We also examined the effects of components of the FEAR pathway, which is involved in the early-anaphase activation of Cdc14 regulatory phosphatase, on anaphase spindle elongation in kip1Δ cin8-F467A cells. Deletion of SLK19, but not SPO12, eliminated the mid-anaphase pause, caused premature anaphase onset and defects in DNA division during anaphase, and reduced viability in these cells. Finally, overriding of the pre-anaphase checkpoint by overexpression of Cdc20 also eliminated the mid-anaphase pause and caused DNA deformation during anaphase in kip1Δ cin8-F467A cells. We propose that transient activation of the pre-anaphase checkpoint in kinesin-5-mutated cells induces a Slk19-dependent mid-anaphase pause, which might be important for proper DNA segregation." @default.
• W2109145958 created "2016-06-24" @default.
• W2109145958 creator A5001101284 @default.
• W2109145958 creator A5009079267 @default.
• W2109145958 creator A5012748365 @default.
• W2109145958 creator A5013794253 @default.
• W2109145958 creator A5018555700 @default.
• W2109145958 creator A5024592904 @default.
• W2109145958 creator A5031600248 @default.
• W2109145958 creator A5043202796 @default.
• W2109145958 creator A5059871169 @default.
• W2109145958 date "2008-08-01" @default.
• W2109145958 modified "2023-09-24" @default.
• W2109145958 title "Slk19-dependent mid-anaphase pause in kinesin-5-mutated cells" @default.
• W2109145958 cites W1483456869 @default.
• W2109145958 cites W1931629225 @default.
• W2109145958 cites W1967921151 @default.
• W2109145958 cites W1969299223 @default.
• W2109145958 cites W1973916918 @default.
• W2109145958 cites W1982515699 @default.
• W2109145958 cites W1983412918 @default.
• W2109145958 cites W1987767376 @default.
• W2109145958 cites W1988678729 @default.
• W2109145958 cites W2000456081 @default.
• W2109145958 cites W2001978459 @default.
• W2109145958 cites W2014462275 @default.
• W2109145958 cites W2027378711 @default.
• W2109145958 cites W2027626281 @default.
• W2109145958 cites W2031284400 @default.
• W2109145958 cites W2033290635 @default.
• W2109145958 cites W2034411357 @default.
• W2109145958 cites W2040472652 @default.
• W2109145958 cites W2041158925 @default.
• W2109145958 cites W2044750332 @default.
• W2109145958 cites W2047439787 @default.
• W2109145958 cites W2055743739 @default.
• W2109145958 cites W2060232163 @default.
• W2109145958 cites W2063760089 @default.
• W2109145958 cites W2068022037 @default.
• W2109145958 cites W2075351483 @default.
• W2109145958 cites W2077402273 @default.
• W2109145958 cites W2080408951 @default.
• W2109145958 cites W2083422545 @default.
• W2109145958 cites W2085659615 @default.
• W2109145958 cites W2085989535 @default.
• W2109145958 cites W2088939436 @default.
• W2109145958 cites W2091912506 @default.
• W2109145958 cites W2099787706 @default.
• W2109145958 cites W2100057937 @default.
• W2109145958 cites W2101176165 @default.
• W2109145958 cites W2105430792 @default.
• W2109145958 cites W2108422673 @default.
• W2109145958 cites W2114638000 @default.
• W2109145958 cites W2120122701 @default.
• W2109145958 cites W2120810427 @default.
• W2109145958 cites W2124595210 @default.
• W2109145958 cites W2126969704 @default.
• W2109145958 cites W2128973947 @default.
• W2109145958 cites W2138429565 @default.
• W2109145958 cites W2138563849 @default.
• W2109145958 cites W2140085943 @default.
• W2109145958 cites W2143596074 @default.
• W2109145958 cites W2146314877 @default.
• W2109145958 cites W2160425990 @default.
• W2109145958 cites W2162503833 @default.
• W2109145958 cites W2168018658 @default.
• W2109145958 cites W2171302195 @default.
• W2109145958 cites W4247827897 @default.
• W2109145958 doi "https://doi.org/10.1242/jcs.022996" @default.
• W2109145958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18628309" @default.
• W2109145958 hasPublicationYear "2008" @default.
• W2109145958 type Work @default.
• W2109145958 sameAs 2109145958 @default.
• W2109145958 citedByCount "28" @default.
• W2109145958 countsByYear W21091459582012 @default.
• W2109145958 countsByYear W21091459582013 @default.
• W2109145958 countsByYear W21091459582015 @default.
• W2109145958 countsByYear W21091459582016 @default.
• W2109145958 countsByYear W21091459582017 @default.
• W2109145958 countsByYear W21091459582018 @default.
• W2109145958 countsByYear W21091459582019 @default.
• W2109145958 countsByYear W21091459582020 @default.
• W2109145958 countsByYear W21091459582021 @default.
• W2109145958 countsByYear W21091459582022 @default.
• W2109145958 countsByYear W21091459582023 @default.
• W2109145958 crossrefType "journal-article" @default.
• W2109145958 hasAuthorship W2109145958A5001101284 @default.
• W2109145958 hasAuthorship W2109145958A5009079267 @default.
• W2109145958 hasAuthorship W2109145958A5012748365 @default.
• W2109145958 hasAuthorship W2109145958A5013794253 @default.
• W2109145958 hasAuthorship W2109145958A5018555700 @default.
• W2109145958 hasAuthorship W2109145958A5024592904 @default.
• W2109145958 hasAuthorship W2109145958A5031600248 @default.
• W2109145958 hasAuthorship W2109145958A5043202796 @default.
• W2109145958 hasAuthorship W2109145958A5059871169 @default.
• W2109145958 hasConcept C1491633281 @default.
• W2109145958 hasConcept C20418707 @default.
• W2109145958 hasConcept C29537977 @default.

• next