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• W2109149072 abstract "Four conformationally restricted analogues of pentamidine were prepared. Then, different concentrations (0.039, 0.078, 0.156, 0.312 and 0.625 mg/mL) of each compound and two positive controls (amphotericin B and pentamidine, 0.625 mg/mL), one negative control (culture medium) and one solvent control (DMSO) were prepared and placed in 24-well plates containing 50000 parasite per well. Promastigotes of Leishmania major were incubated over a period of 2 days at 25°C; subsequently, percent of viable parasite in each well determined spectrophotometrically using MTT assay. The average EC 50 for compounds 4a,b and 8a,b in DMSO was 0.098, 0.410, 0.150, 0.720 mg/mL, respectively. The average EC 50 for positive controls pentamidine and amphotericin B was found to be 0.062 and 0.026 mg/mL. The control" @default.
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• W2109149072 date "2009-01-01" @default.
• W2109149072 modified "2023-09-25" @default.
• W2109149072 title "Synthesis and In Vitro Leishmanicidal Effects of Conformationally Restricted Analogues of Pentamidine" @default.
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• W2109149072 doi "https://doi.org/10.22037/ijpr.2010.819" @default.
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