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- W2109155306 abstract "A key step in bacterial transcription initiation is melting of the double-stranded promoter DNA by the RNA polymerase holoenzyme. Primary sigma factors mediate the melting of thousands of promoters through a conserved set of aromatic amino acids. Alternative sigmas, which direct transcription of restricted regulons, lack the full set of melting residues. In this issue of Genes & Development, Koo and colleagues (pp. 2426-2436) show that introducing the primary sigma melting residues into alternative sigmas relaxes their promoter specificity, pointing to a trade-off of reduced promoter melting capacity for increased promoter stringency." @default.
- W2109155306 created "2016-06-24" @default.
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- W2109155306 date "2009-10-15" @default.
- W2109155306 modified "2023-09-27" @default.
- W2109155306 title "Promoter recognition by bacterial alternative σ factors: the price of high selectivity?: Figure 1." @default.
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- W2109155306 doi "https://doi.org/10.1101/gad.1862609" @default.
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