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- W2109156891 abstract "The 2.2 Mb long dystrophin (DMD) gene, the largest gene in the human genome, corresponds to roughly 0.1% of the entire human DNA sequence. Mutations in this gene cause Duchenne muscular dystrophy and other milder X-linked, recessive dystrophinopathies. Using a custom-made tiling array, specifically designed for the DMD locus, we identified a variety of novel long non-coding RNAs (lncRNAs), both sense and antisense oriented, whose expression profiles mirror that of DMD gene. Importantly, these transcripts are intronic in origin and specifically localized to the nucleus and are transcribed contextually with dystrophin isoforms or primed by MyoD-induced myogenic differentiation. Furthermore, their forced ectopic expression in both human muscle and neuronal cells causes a specific and negative regulation of endogenous dystrophin full length isoforms and significantly down-regulate the activity of a luciferase reporter construct carrying the minimal promoter regions of the muscle dystrophin isoform. Consistent with this apparently repressive role, we found that, in muscle samples of dystrophinopathic female carriers, lncRNAs expression levels inversely correlate with those of muscle full length DMD isoforms. Overall these findings unveil an unprecedented complexity of the transcriptional pattern of the DMD locus and reveal that DMD lncRNAs may contribute to the orchestration and homeostasis of the muscle dystrophin expression pattern by either selective targeting and down-modulating the dystrophin promoter transcriptional activity." @default.
- W2109156891 created "2016-06-24" @default.
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- W2109156891 date "2012-09-21" @default.
- W2109156891 modified "2023-09-25" @default.
- W2109156891 title "The DMD Locus Harbours Multiple Long Non-Coding RNAs Which Orchestrate and Control Transcription of Muscle Dystrophin mRNA Isoforms" @default.
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- W2109156891 cites W1973622458 @default.
- W2109156891 cites W1979747200 @default.
- W2109156891 cites W1985975914 @default.
- W2109156891 cites W1990261634 @default.
- W2109156891 cites W1999746344 @default.
- W2109156891 cites W1999814091 @default.
- W2109156891 cites W2001806905 @default.
- W2109156891 cites W2003931365 @default.
- W2109156891 cites W2006107100 @default.
- W2109156891 cites W2006167464 @default.
- W2109156891 cites W2007103799 @default.
- W2109156891 cites W2010757394 @default.
- W2109156891 cites W2014534727 @default.
- W2109156891 cites W2026726511 @default.
- W2109156891 cites W2027011944 @default.
- W2109156891 cites W2030288656 @default.
- W2109156891 cites W2031129013 @default.
- W2109156891 cites W2033094967 @default.
- W2109156891 cites W2034023446 @default.
- W2109156891 cites W2035095433 @default.
- W2109156891 cites W2038663466 @default.
- W2109156891 cites W2038696333 @default.
- W2109156891 cites W2039408641 @default.
- W2109156891 cites W2040751058 @default.
- W2109156891 cites W2040786304 @default.
- W2109156891 cites W2041902006 @default.
- W2109156891 cites W2044964290 @default.
- W2109156891 cites W2046329168 @default.
- W2109156891 cites W2058711543 @default.
- W2109156891 cites W2059478037 @default.
- W2109156891 cites W206006761 @default.
- W2109156891 cites W2060390444 @default.
- W2109156891 cites W2060676431 @default.
- W2109156891 cites W2061797512 @default.
- W2109156891 cites W2062119517 @default.
- W2109156891 cites W2067889824 @default.
- W2109156891 cites W2068367615 @default.
- W2109156891 cites W2072832813 @default.
- W2109156891 cites W2085014031 @default.
- W2109156891 cites W2085516557 @default.
- W2109156891 cites W2087377443 @default.
- W2109156891 cites W2088017477 @default.
- W2109156891 cites W2091204895 @default.
- W2109156891 cites W2094571195 @default.
- W2109156891 cites W2099468911 @default.
- W2109156891 cites W2103419911 @default.
- W2109156891 cites W2104496518 @default.
- W2109156891 cites W2105292164 @default.
- W2109156891 cites W2105599389 @default.
- W2109156891 cites W2106554405 @default.
- W2109156891 cites W2110992276 @default.
- W2109156891 cites W2112001233 @default.
- W2109156891 cites W2120246366 @default.
- W2109156891 cites W2125013165 @default.
- W2109156891 cites W2125946663 @default.
- W2109156891 cites W2125984352 @default.
- W2109156891 cites W2126356636 @default.
- W2109156891 cites W2129078669 @default.
- W2109156891 cites W2130599655 @default.
- W2109156891 cites W2136725005 @default.
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- W2109156891 cites W2146648170 @default.
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- W2109156891 cites W2153222734 @default.
- W2109156891 cites W2155644021 @default.
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- W2109156891 doi "https://doi.org/10.1371/journal.pone.0045328" @default.
- W2109156891 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3448672" @default.
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- W2109156891 hasPublicationYear "2012" @default.
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