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• W2109157083 endingPage "77" @default.
• W2109157083 startingPage "69" @default.
• W2109157083 abstract "Background: Composed of endocardial endothelial, valvular interstitial, cardiac muscle, and smooth muscle cells (SMC), heart valves are prone to various pathologic conditions the morphology of which has been well described. The morphology of diseased valves suggest that the “response to injury” process occurs in these valves, and is associated with an accumulation of interstitial cells and matrix, valvular inflammation and calcification, conditions that lead to dysfunction. The purpose of this study is to describe the current knowledge of the regulation of the valvular “response to injury” process, since we feel that this paradigm is essential to understanding valve disease. Methods: The pertinent literature relating to the cell and molecular biology of valvular repair, and specifically interstitial cell function in valve repair, is reviewed. Results: The cell and molecular biology of valve interstitial cells are poorly understood. Molecules regulating some of the aspects of the “response to injury” process have been studied, however, the signal transduction pathways, gene activation, and interactions of bioactive molecules with each other, with cells, and with the matrix have not been characterized. Initial studies identify the cell and molecular biology of interstitial cells to be an important area of research. Agents that have been studied include nitric oxide (NO) and FGF-2 and several matrix-related proteins including osteopontin. The present review suggests several directions for future study and a working model of valvular repair is presented. Discussion: The regulation of the “response to injury” process in the human heart valve is still largely unknown. The cell and molecular events and processes that occur in heart valve function and repair remain poorly understood. These events and processes are vital to our understanding of the pathobiology of heart valve disease, and to the successful design of tissue engineered replacement valves." @default.
• W2109157083 created "2016-06-24" @default.
• W2109157083 creator A5025369816 @default.
• W2109157083 creator A5059546406 @default.
• W2109157083 date "2002-03-01" @default.
• W2109157083 modified "2023-10-13" @default.
• W2109157083 title "Advances towards understanding heart valve response to injury" @default.
• W2109157083 cites W1549544590 @default.
• W2109157083 cites W1553050604 @default.
• W2109157083 cites W1597110487 @default.
• W2109157083 cites W1606615500 @default.
• W2109157083 cites W1939982746 @default.
• W2109157083 cites W1965094170 @default.
• W2109157083 cites W1965304525 @default.
• W2109157083 cites W1967545054 @default.
• W2109157083 cites W1968108524 @default.
• W2109157083 cites W1969079241 @default.
• W2109157083 cites W1970159544 @default.
• W2109157083 cites W1971510126 @default.
• W2109157083 cites W1975709087 @default.
• W2109157083 cites W1979402648 @default.
• W2109157083 cites W1984872320 @default.
• W2109157083 cites W1985277152 @default.
• W2109157083 cites W1985741777 @default.
• W2109157083 cites W1986812753 @default.
• W2109157083 cites W1987561858 @default.
• W2109157083 cites W1989021197 @default.
• W2109157083 cites W1996723382 @default.
• W2109157083 cites W1996819399 @default.
• W2109157083 cites W1996834548 @default.
• W2109157083 cites W1997379270 @default.
• W2109157083 cites W1999340769 @default.
• W2109157083 cites W2001954819 @default.
• W2109157083 cites W2003055114 @default.
• W2109157083 cites W2006705030 @default.
• W2109157083 cites W2006781499 @default.
• W2109157083 cites W2007660746 @default.
• W2109157083 cites W2008905300 @default.
• W2109157083 cites W2009451441 @default.
• W2109157083 cites W2010114423 @default.
• W2109157083 cites W2013105546 @default.
• W2109157083 cites W2014914858 @default.
• W2109157083 cites W2016637403 @default.
• W2109157083 cites W2017698636 @default.
• W2109157083 cites W2018314802 @default.
• W2109157083 cites W2019555687 @default.
• W2109157083 cites W2021478319 @default.
• W2109157083 cites W2029773366 @default.
• W2109157083 cites W2033201483 @default.
• W2109157083 cites W2033708131 @default.
• W2109157083 cites W2036174481 @default.
• W2109157083 cites W2037552908 @default.
• W2109157083 cites W2039017944 @default.
• W2109157083 cites W2039182800 @default.
• W2109157083 cites W2040189638 @default.
• W2109157083 cites W2040658805 @default.
• W2109157083 cites W2043941389 @default.
• W2109157083 cites W2045272081 @default.
• W2109157083 cites W2046996049 @default.
• W2109157083 cites W2047135655 @default.
• W2109157083 cites W2047398492 @default.
• W2109157083 cites W2047411551 @default.
• W2109157083 cites W2050698208 @default.
• W2109157083 cites W2052372646 @default.
• W2109157083 cites W2057044649 @default.
• W2109157083 cites W2057044951 @default.
• W2109157083 cites W2060877230 @default.
• W2109157083 cites W2062352019 @default.
• W2109157083 cites W2063871555 @default.
• W2109157083 cites W2065664487 @default.
• W2109157083 cites W2066676769 @default.
• W2109157083 cites W2069050052 @default.
• W2109157083 cites W2070236185 @default.
• W2109157083 cites W2075247220 @default.
• W2109157083 cites W2076289971 @default.
• W2109157083 cites W2077239977 @default.
• W2109157083 cites W2077744249 @default.
• W2109157083 cites W2083493888 @default.
• W2109157083 cites W2083643089 @default.
• W2109157083 cites W2084058997 @default.
• W2109157083 cites W2084831922 @default.
• W2109157083 cites W2089003710 @default.
• W2109157083 cites W2091130630 @default.
• W2109157083 cites W2091911301 @default.
• W2109157083 cites W2092690876 @default.
• W2109157083 cites W2093226717 @default.
• W2109157083 cites W2095153236 @default.
• W2109157083 cites W2101480539 @default.
• W2109157083 cites W2102969844 @default.
• W2109157083 cites W2104974378 @default.
• W2109157083 cites W2107429652 @default.
• W2109157083 cites W2110610344 @default.
• W2109157083 cites W2112692194 @default.
• W2109157083 cites W2116037783 @default.
• W2109157083 cites W2121696981 @default.
• W2109157083 cites W2123142710 @default.
• W2109157083 cites W2126618234 @default.
• W2109157083 cites W2127737656 @default.

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