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• W2109162445 abstract "<h3>Objective</h3> Consumption of fish and marine n-3 polyunsaturated fatty acids (PUFA) may be associated with a lower risk of atrial fibrillation (AF), but results have been inconsistent. The aim was to investigate this further by measurements of marine n-3 PUFA in adipose tissue. <h3>Design</h3> Cohort study. <h3>Setting</h3> A total of 57 053 Danish participants 50–64 years of age were enrolled into the Diet, Cancer and Health Cohort Study. <h3>Patients</h3> A randomly drawn subcohort of 3440 participants with available data from baseline adipose tissue biopsies. <h3>Interventions</h3> Exposure was the adipose tissue content of marine n-3 PUFA, which reflects the endogenous exposure and is also an objective marker of the long-term dietary intake. <h3>Main outcome measures</h3> Incident AF during follow-up. <h3>Results</h3> 179 cases of AF occurred over 13.6 years. Multivariate, sex-stratified Cox proportional hazards regression analyses using cubic splines showed a monotonic, negative, dose-response trend, but not statistically significant association, between total marine n-3 PUFA in adipose tissue and incident AF. A similar trend towards a lower risk of AF was seen in the second (HR 0.87, 95% CI 0.60 to 1.24) and third tertiles (HR 0.77, 95% CI 0.53 to 1.10) of marine n-3 PUFA compared with the lowest tertile. Similar trends, but also not statistically significant, were found separately for eicosapentaenoic, docosahexaenoic and docosapentaenoic acids. <h3>Conclusions</h3> There was no statistically significant association between the content of marine n-3 PUFA in adipose tissue and the development of AF; however, data showed a monotonic, negative dose-response trend suggestive of a negative association." @default.
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• W2109162445 date "2013-08-14" @default.
• W2109162445 modified "2023-09-25" @default.
• W2109162445 title "Marine n-3 fatty acids in adipose tissue and development of atrial fibrillation: a Danish cohort study" @default.
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• W2109162445 doi "https://doi.org/10.1136/heartjnl-2013-304385" @default.
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