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• W2109163804 abstract "We studied the impact of wall strain and surrounding pressure on the onset of airflow limitation in a thin-walled “floppy” tube model. A vacuum source-generated steady-state (baseline) airflow (0–350 ml/s) through a thin-walled latex tube (length 80 mm, wall thickness 0.23 mm) enclosed within a rigid, sealed, air-filled, cylindrical chamber while upstream minus downstream pressure, chamber pressure (Pc), and lumen geometry [in-line digital camera; segmentation (Amira 5.2.2) and analysis (Rhinoceros 4) software] were monitored. Longitudinal strain (S; 0–62.5%) and Pc (0–20 cmH 2 O) combinations were imposed, and Pc associated with onset of 1) reduced airflow and 2) fully developed airflow limitation recorded. At any strain, increasing Pc resulted in a decrease in airflow. Across all baseline airflow, threshold pressure was 1–7 cmH 2 O for S < 25%, 6–8 cmH 2 O at S = 25% and 37.5%, and 5–7 cmH 2 O at S = 50% and 62.5%. Pc associated with fully developed airflow limitation was 4–6 cmH 2 O for S < 25%, >20 cmH 2 O at S = 25% (i.e., no flow limitation), 18 cmH 2 O at S = 37.5%, and 8–12 cmH 2 O at S = 50% and 62.5%. Lumen area decreased with increasing Pc but was 1) larger at S = 25% and 2) characterized by bifold narrowing at S < 25% and trifold narrowing at S ≥ 25%. In conclusion, tube function was modulated by Pc vs. S interactions, with S = 25% producing trifold lumen narrowing, maximal patency, and no airflow limitation. Findings may have implications for understanding peripharyngeal tissue pressure and pharyngeal wall strain effects on passive pharyngeal airway function in humans." @default.
• W2109163804 created "2016-06-24" @default.
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• W2109163804 date "2010-11-01" @default.
• W2109163804 modified "2023-09-26" @default.
• W2109163804 title "Onset of airflow limitation in a collapsible tube model: impact of surrounding pressure, longitudinal strain, and wall folding geometry" @default.
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• W2109163804 doi "https://doi.org/10.1152/japplphysiol.00096.2010" @default.
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