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• W2109164945 startingPage "13099" @default.
• W2109164945 abstract "Significance Understanding how synaptic inhibition regulates sensory responses is a fundamental question in neuroscience. In cerebellar granule cells, sensory stimulation is thought to evoke an excitation–inhibition sequence driven by direct input from mossy fibers and followed by classical disynaptic feed-forward inhibition from nearby Golgi cells. We made, to our knowledge, the first voltage-clamp recordings of sensory-evoked inhibition in granule cells in vivo and show that, surprisingly, sensory-evoked inhibition often precedes mossy fiber excitation activated by the same stimulus. We demonstrate how such “preceding” inhibition can shape granule cell responses to sensory stimulation. Our findings challenge the existing view that classical feed-forward inhibition is the dominant mode of inhibition, suggesting that parallel inhibitory networks regulate sensory information transmission through the granular layer." @default.
• W2109164945 created "2016-06-24" @default.
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• W2109164945 date "2015-10-02" @default.
• W2109164945 modified "2023-09-29" @default.
• W2109164945 title "Control of cerebellar granule cell output by sensory-evoked Golgi cell inhibition" @default.
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• W2109164945 doi "https://doi.org/10.1073/pnas.1510249112" @default.
• W2109164945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4620892" @default.
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