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- W2109167913 endingPage "e0124017" @default.
- W2109167913 startingPage "e0124017" @default.
- W2109167913 abstract "Adenylyl cyclases (ACs) catalyze the conversion of ATP into the second messenger cAMP. Membranous AC1 (AC1) is involved in processes of memory and learning and in muscle pain. The AC toxin edema factor (EF) of Bacillus anthracis is involved in the development of anthrax. Both ACs are stimulated by the eukaryotic Ca(2+)-sensor calmodulin (CaM). The CaM-AC interaction could constitute a potential target to enhance or impair the AC activity of AC1 and EF to intervene in above (patho)physiological mechanisms. Thus, we analyzed the impact of 39 compounds including typical CaM-inhibitors, an anticonvulsant, an anticholinergic, antidepressants, antipsychotics and Ca(2+)-antagonists on CaM-stimulated catalytic activity of AC1 and EF. Compounds were tested at 10 μM, i.e., a concentration that can be reached therapeutically for certain antidepressants and antipsychotics. Calmidazolium chloride decreased CaM-stimulated AC1 activity moderately by about 30%. In contrast, CaM-stimulated EF activity was abrogated by calmidazolium chloride and additionally decreased by chlorpromazine, felodipine, penfluridol and trifluoperazine by about 20-40%. The activity of both ACs was decreased by calmidazolium chloride in the presence and absence of CaM. Thus, CaM-stimulated AC1 activity is more insensitive to inhibition by small molecules than CaM-stimulated EF activity. Inhibition of AC1 and EF by calmidazolium chloride is largely mediated via a CaM-independent allosteric mechanism." @default.
- W2109167913 created "2016-06-24" @default.
- W2109167913 creator A5040439170 @default.
- W2109167913 creator A5074094838 @default.
- W2109167913 date "2015-05-06" @default.
- W2109167913 modified "2023-10-16" @default.
- W2109167913 title "Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor" @default.
- W2109167913 cites W1031388349 @default.
- W2109167913 cites W1431623250 @default.
- W2109167913 cites W1518893249 @default.
- W2109167913 cites W1534487896 @default.
- W2109167913 cites W1549745457 @default.
- W2109167913 cites W1572956640 @default.
- W2109167913 cites W1583253515 @default.
- W2109167913 cites W1775749144 @default.
- W2109167913 cites W1829840485 @default.
- W2109167913 cites W1951746469 @default.
- W2109167913 cites W1965727223 @default.
- W2109167913 cites W1968901680 @default.
- W2109167913 cites W1974889144 @default.
- W2109167913 cites W1974917488 @default.
- W2109167913 cites W1977508498 @default.
- W2109167913 cites W1978952396 @default.
- W2109167913 cites W1981724666 @default.
- W2109167913 cites W1984399239 @default.
- W2109167913 cites W1985972401 @default.
- W2109167913 cites W1986308935 @default.
- W2109167913 cites W1989977352 @default.
- W2109167913 cites W1996135614 @default.
- W2109167913 cites W1998456482 @default.
- W2109167913 cites W1998792166 @default.
- W2109167913 cites W2003898260 @default.
- W2109167913 cites W2006037920 @default.
- W2109167913 cites W2007902074 @default.
- W2109167913 cites W2008841385 @default.
- W2109167913 cites W2009725722 @default.
- W2109167913 cites W2010058764 @default.
- W2109167913 cites W2012666208 @default.
- W2109167913 cites W2015211831 @default.
- W2109167913 cites W2016701637 @default.
- W2109167913 cites W2022789859 @default.
- W2109167913 cites W2023062743 @default.
- W2109167913 cites W2030669640 @default.
- W2109167913 cites W2033353019 @default.
- W2109167913 cites W2036225240 @default.
- W2109167913 cites W2040567895 @default.
- W2109167913 cites W2041578033 @default.
- W2109167913 cites W2042139493 @default.
- W2109167913 cites W2043272065 @default.
- W2109167913 cites W2044750367 @default.
- W2109167913 cites W2046291488 @default.
- W2109167913 cites W2047848482 @default.
- W2109167913 cites W2049356398 @default.
- W2109167913 cites W2052366943 @default.
- W2109167913 cites W2055802786 @default.
- W2109167913 cites W2056955051 @default.
- W2109167913 cites W2061693060 @default.
- W2109167913 cites W2075133686 @default.
- W2109167913 cites W2079896672 @default.
- W2109167913 cites W2083259821 @default.
- W2109167913 cites W2084344997 @default.
- W2109167913 cites W2086164109 @default.
- W2109167913 cites W2086635215 @default.
- W2109167913 cites W2087185671 @default.
- W2109167913 cites W2089039697 @default.
- W2109167913 cites W2092763509 @default.
- W2109167913 cites W2096942328 @default.
- W2109167913 cites W2097783955 @default.
- W2109167913 cites W2098678018 @default.
- W2109167913 cites W2099897283 @default.
- W2109167913 cites W2104075210 @default.
- W2109167913 cites W2118469169 @default.
- W2109167913 cites W2129075836 @default.
- W2109167913 cites W2131139238 @default.
- W2109167913 cites W2136560949 @default.
- W2109167913 cites W2137662714 @default.
- W2109167913 cites W2144884547 @default.
- W2109167913 cites W2157200764 @default.
- W2109167913 cites W2176061808 @default.
- W2109167913 cites W2253302896 @default.
- W2109167913 cites W2314940363 @default.
- W2109167913 cites W2337009177 @default.
- W2109167913 cites W2409521202 @default.
- W2109167913 cites W2410835544 @default.
- W2109167913 cites W2461649126 @default.
- W2109167913 cites W2469078899 @default.
- W2109167913 cites W2470869994 @default.
- W2109167913 cites W37904182 @default.
- W2109167913 cites W4229857880 @default.
- W2109167913 cites W4230045353 @default.
- W2109167913 cites W4231530219 @default.
- W2109167913 doi "https://doi.org/10.1371/journal.pone.0124017" @default.
- W2109167913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4422518" @default.
- W2109167913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25946093" @default.
- W2109167913 hasPublicationYear "2015" @default.
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