Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109169395> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2109169395 endingPage "1061" @default.
- W2109169395 startingPage "1040" @default.
- W2109169395 abstract "Cancer drugs are commonly administered in the clinic in the form of mixtures, also called cocktails or combinations. Assessment of synergistic and antagonistic interactions between drugs is therefore an important aspect of cancer research. Numerous methods have been proposed to assess drug interactions, each one based on a null (or additive) model. In this paper, the Loewe additivity index is used as a basis. Parameters of concentration-response curves, used as input to the Loewe equation, are estimated with a nonlinear mixed-effects model. The use of a nonlinear mixed-effects model, in combination with the Loewe index and a procedure to calculate confidence intervals of the index, is referred to as the 'MixLow' method. Simulations of a sham mixture of a drug with itself show that the MixLow method provides parameter estimators that are more precise than those produced by the Median-Effect method, a popular approach that uses log linearization of the concentration-response curves. Coverage of confidence intervals for the interaction index is acceptable for the MixLow method but poor for the Median-Effect method. This is the first comparison report of coverage of confidence intervals for the Loewe interaction index. A mixture of vincristine and topotecan is also analyzed by the MixLow method and the results are compared with those previously published. The MixLow method can be used to quantify drug interactions in any fixed-ratio drug combination study that includes within-group and between-group replicates, and where responses follow a sigmoidal pattern." @default.
- W2109169395 created "2016-06-24" @default.
- W2109169395 creator A5028700093 @default.
- W2109169395 creator A5053753399 @default.
- W2109169395 creator A5083929738 @default.
- W2109169395 date "2008-01-01" @default.
- W2109169395 modified "2023-09-27" @default.
- W2109169395 title "Quantifying synergism/antagonism using nonlinear mixed-effects modeling: A simulation study" @default.
- W2109169395 cites W1971311670 @default.
- W2109169395 cites W2018829597 @default.
- W2109169395 cites W2019173334 @default.
- W2109169395 cites W2023123872 @default.
- W2109169395 cites W2033799417 @default.
- W2109169395 cites W2047746146 @default.
- W2109169395 cites W2077945404 @default.
- W2109169395 cites W2078291699 @default.
- W2109169395 cites W2083654678 @default.
- W2109169395 cites W2091787052 @default.
- W2109169395 cites W2103562758 @default.
- W2109169395 cites W2109574777 @default.
- W2109169395 cites W2154105809 @default.
- W2109169395 cites W2165330647 @default.
- W2109169395 cites W2167974749 @default.
- W2109169395 cites W2169078162 @default.
- W2109169395 doi "https://doi.org/10.1002/sim.3005" @default.
- W2109169395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17768754" @default.
- W2109169395 hasPublicationYear "2008" @default.
- W2109169395 type Work @default.
- W2109169395 sameAs 2109169395 @default.
- W2109169395 citedByCount "48" @default.
- W2109169395 countsByYear W21091693952013 @default.
- W2109169395 countsByYear W21091693952014 @default.
- W2109169395 countsByYear W21091693952015 @default.
- W2109169395 countsByYear W21091693952016 @default.
- W2109169395 countsByYear W21091693952017 @default.
- W2109169395 countsByYear W21091693952018 @default.
- W2109169395 countsByYear W21091693952019 @default.
- W2109169395 countsByYear W21091693952020 @default.
- W2109169395 countsByYear W21091693952022 @default.
- W2109169395 crossrefType "journal-article" @default.
- W2109169395 hasAuthorship W2109169395A5028700093 @default.
- W2109169395 hasAuthorship W2109169395A5053753399 @default.
- W2109169395 hasAuthorship W2109169395A5083929738 @default.
- W2109169395 hasConcept C105795698 @default.
- W2109169395 hasConcept C121332964 @default.
- W2109169395 hasConcept C154945302 @default.
- W2109169395 hasConcept C158622935 @default.
- W2109169395 hasConcept C33923547 @default.
- W2109169395 hasConcept C41008148 @default.
- W2109169395 hasConcept C44249647 @default.
- W2109169395 hasConcept C50644808 @default.
- W2109169395 hasConcept C62520636 @default.
- W2109169395 hasConcept C81388566 @default.
- W2109169395 hasConceptScore W2109169395C105795698 @default.
- W2109169395 hasConceptScore W2109169395C121332964 @default.
- W2109169395 hasConceptScore W2109169395C154945302 @default.
- W2109169395 hasConceptScore W2109169395C158622935 @default.
- W2109169395 hasConceptScore W2109169395C33923547 @default.
- W2109169395 hasConceptScore W2109169395C41008148 @default.
- W2109169395 hasConceptScore W2109169395C44249647 @default.
- W2109169395 hasConceptScore W2109169395C50644808 @default.
- W2109169395 hasConceptScore W2109169395C62520636 @default.
- W2109169395 hasConceptScore W2109169395C81388566 @default.
- W2109169395 hasIssue "7" @default.
- W2109169395 hasLocation W21091693951 @default.
- W2109169395 hasLocation W21091693952 @default.
- W2109169395 hasOpenAccess W2109169395 @default.
- W2109169395 hasPrimaryLocation W21091693951 @default.
- W2109169395 hasRelatedWork W1592683135 @default.
- W2109169395 hasRelatedWork W1899429405 @default.
- W2109169395 hasRelatedWork W1973036726 @default.
- W2109169395 hasRelatedWork W2051221975 @default.
- W2109169395 hasRelatedWork W2113937888 @default.
- W2109169395 hasRelatedWork W2119158312 @default.
- W2109169395 hasRelatedWork W2140208577 @default.
- W2109169395 hasRelatedWork W2401903608 @default.
- W2109169395 hasRelatedWork W2995364151 @default.
- W2109169395 hasRelatedWork W797163146 @default.
- W2109169395 hasVolume "27" @default.
- W2109169395 isParatext "false" @default.
- W2109169395 isRetracted "false" @default.
- W2109169395 magId "2109169395" @default.
- W2109169395 workType "article" @default.