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• W2109169619 endingPage "7635" @default.
• W2109169619 startingPage "7626" @default.
• W2109169619 abstract "The relationship between sequence and binding properties of an aptamer for immunoglobulin E (IgE) was investigated using custom DNA microarrays. Single, double and some triple mutations of the aptamer sequence were created to evaluate the importance of specific base composition on aptamer binding. The majority of the positions in the aptamer sequence were found to be immutable, with changes at these positions resulting in more than a 100-fold decrease in binding affinity. Improvements in binding were observed by altering the stem region of the aptamer, suggesting that it plays a significant role in binding. Results obtained for the various mutations were used to estimate the information content and the probability of finding a functional aptamer sequence by selection from a random library. For the IgE-binding aptamer, this probability is on the order of 10 − 10 to 10 − 9 . Results obtained for the double and triple mutations also show that there are no compensatory mutations within the space defined by those mutations. Apparently, at least for this particular aptamer, the functional sequence space can be represented as a rugged landscape with sharp peaks defined by highly constrained base compositions. This makes the rational optimization of aptamer sequences using step-wise mutagenesis approaches very challenging." @default.
• W2109169619 created "2016-06-24" @default.
• W2109169619 creator A5001382756 @default.
• W2109169619 creator A5014844518 @default.
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• W2109169619 date "2007-11-02" @default.
• W2109169619 modified "2023-10-15" @default.
• W2109169619 title "Exploring the sequence space of a DNA aptamer using microarrays" @default.
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• W2109169619 doi "https://doi.org/10.1093/nar/gkm922" @default.
• W2109169619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2190713" @default.
• W2109169619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17981839" @default.
• W2109169619 hasPublicationYear "2007" @default.
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