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- W2109173831 abstract "Torque teno viruses (TTVs) share several genomic similarities with the chicken anemia virus (CAV). CAV encodes the protein apoptin that specifically induces apoptosis in (human) tumor cells. Functional studies reveal that apoptin induces apoptosis in a very broad range of (human) tumor cells. A putative TTV open reading frame (ORF) in TTV genotype 1, named TTV apoptosis inducing protein (TAIP), it induces, like apoptin, p53-independent apoptosis in various human hepato-carcinoma cell lines to a similar level as apoptin. In comparison to apoptin, TAIP action is less pronounced in several analyzed human non-hepatocarcinoma-derived cell lines. Detailed sequence analysis has revealed that the TAIP ORF is conserved within a limited group of the heterogeneous TTV population. However, its N-terminal half, N-TAIP, is rather well conserved in a much broader set of TTV isolates. The similarities between apoptin and TAIP, and their relevance for the development and treatment of diseases is discussed.KeywordsTorque Teno VirusORF3 ProteinChicken Anemia VirusApoptosis ActivityTorque Teno Virus InfectionThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W2109173831 created "2016-06-24" @default.
- W2109173831 creator A5060470399 @default.
- W2109173831 creator A5074994779 @default.
- W2109173831 date "2009-01-01" @default.
- W2109173831 modified "2023-09-29" @default.
- W2109173831 title "Apoptosis-Inducing Proteins in Chicken Anemia Virus and TT Virus" @default.
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- W2109173831 doi "https://doi.org/10.1007/978-3-540-70972-5_9" @default.
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