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- W2109174310 abstract "The aim of the present work is to formulate a tablet which disintegrate and dissolve rapidly and give its rapid onset of action: analgesic, antipyretic and anti inflammatory action. Diclofenac sodium is among the most extensively used NSAIDs; employed in musculoskeletal complaints, especially arthritis. Conventional diclofinac sodium tablet available in market are not suitable where quick onset of action is required. Besides, the conventional tablets also show poor patient compliance particularly by geriatric and pediatric patients and those who are suffering from dysphegia, nausea and vomiting. Fast dissolving tablet (FDT) offer maximum advantage for those patients’ particularly pediatric and geriatric patients who are not able to swallow traditional tablets and capsules. In present study, an attempt had been made to formulate for FDT of diclofinac sodium by using various superdisintigrant like sodium starch glycolate, croscarmellose sodium and crosspovidone (polyplasdone XL) followed by direct compression technique. The tablets were evaluated for weight variation, hardness, friability, disintegration time, wetting time, in vitro dissolution studies and drug content. It was concluded that the batch which was prepared by using combination of crosspovidone and sodium starch glycolate as a superdisintigrant shows excellent disintegration time, enhance dissolution rate, taste masking and hence lead to improve efficacy and bioavaibility of drug." @default.
- W2109174310 created "2016-06-24" @default.
- W2109174310 creator A5043398236 @default.
- W2109174310 date "2012-01-01" @default.
- W2109174310 modified "2023-09-24" @default.
- W2109174310 title "Formulation and Evaluation of Fast Dissolving Tablets of Diclofenac Sodium Using Different Superdisintigrants by Direct Compression Method" @default.
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