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- W2109183823 abstract "Urinary tract infections (UTIs) are common, dangerous and interesting. Susceptible individuals experience multiple, often clustered episodes, and in a subset of patients, infections progress to acute pyelonephritis (APN), sometimes accompanied by uro-sepsis. Others develop asymptomatic bacteriuria (ABU). Here, we review the molecular basis for these differences, with the intention to distinguish exaggerated host responses that drive disease from attenuated responses that favour protection and to highlight the genetic basis for these extremes, based on knock-out mice and clinical studies.The susceptibility to UTI is controlled by specific innate immune signalling and by promoter polymorphisms and transcription factors that modulate the expression of genes controlling these pathways. Gene deletions that disturb innate immune activation either favour asymptomatic bacteriuria or create acute morbidity and disease. Promoter polymorphisms and transcription factor variants affecting those genes are associated with susceptibility in UTI-prone patients.It is time to start using genetics in UTI-prone patients, to improve diagnosis and to assess the risk for chronic sequels such as renal malfunction, hypertension, spontaneous abortions, dialysis and transplantation. Furthermore, the majority of UTI patients do not need follow-up, but for lack of molecular markers, they are unnecessarily investigated." @default.
- W2109183823 created "2016-06-24" @default.
- W2109183823 creator A5013601021 @default.
- W2109183823 creator A5044790389 @default.
- W2109183823 creator A5075750865 @default.
- W2109183823 date "2015-02-01" @default.
- W2109183823 modified "2023-10-18" @default.
- W2109183823 title "Innate immunity and genetic determinants of urinary tract infection susceptibility" @default.
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- W2109183823 cites W1958230690 @default.
- W2109183823 cites W1959547582 @default.
- W2109183823 cites W1970555242 @default.
- W2109183823 cites W1974315097 @default.
- W2109183823 cites W1980273234 @default.
- W2109183823 cites W1986205407 @default.
- W2109183823 cites W1987680142 @default.
- W2109183823 cites W2001959707 @default.
- W2109183823 cites W2005365259 @default.
- W2109183823 cites W2005683847 @default.
- W2109183823 cites W2009181053 @default.
- W2109183823 cites W2019626412 @default.
- W2109183823 cites W2022548242 @default.
- W2109183823 cites W2025544070 @default.
- W2109183823 cites W2028114960 @default.
- W2109183823 cites W2029712692 @default.
- W2109183823 cites W2032695563 @default.
- W2109183823 cites W2039140299 @default.
- W2109183823 cites W2040527066 @default.
- W2109183823 cites W2041819961 @default.
- W2109183823 cites W2043633262 @default.
- W2109183823 cites W2044486059 @default.
- W2109183823 cites W2047353791 @default.
- W2109183823 cites W2051596822 @default.
- W2109183823 cites W2055323259 @default.
- W2109183823 cites W2057033769 @default.
- W2109183823 cites W2057805100 @default.
- W2109183823 cites W2060483617 @default.
- W2109183823 cites W2060681530 @default.
- W2109183823 cites W2068419165 @default.
- W2109183823 cites W2072534436 @default.
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- W2109183823 cites W2093281175 @default.
- W2109183823 cites W2095891588 @default.
- W2109183823 cites W2098436673 @default.
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- W2109183823 doi "https://doi.org/10.1097/qco.0000000000000127" @default.
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