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• W2109187721 abstract "Orthogonal electrocardiograms (Frank system) were recorded from 405 patients with pulmonary emphysema of moderate and severe degree. The diagnosis was based on clinical and radiologic or pulmonary function studies, or both, according to uniform study protocols. Of 333 electrocardiographic measurements computed from each record, different sets of diagnostic criteria were selected for optimal separation of records of patients with pulmonary emphysema from those of normal subjects, using a variety of statistical techniques. The first set consisted of five scalar and vector measurements which can be easily obtained and which do not require access to computer facilities. With these criteria, 80 percent of the records of patients with pulmonary emphysema could be correctly classified, with a false positive rate of 11 percent. With a second set of 14 more complex measurements intended for computer use, 81 percent of pulmonary emphysema tracings were classified correctly, with a reduction in false positives to 5 percent. With the use of additional criteria, a series of 140 records from patients with right ventricular hypertrophy due to pure mitral stenosis could be differentiated from records of patients with pulmonary emphysema in 80 percent of cases. Reduction of the R wave and the R:S ratio in lead X proved to be the best discriminators between records of normal subjects and those of patients with pulmonary emphysema. Correlations with arterial pCO2 showed progression of Rx changes, a QRS shift in a superior direction and a rightward shift of the P wave as the best indicators of deteriorating pulmonary function. Classification procedures were tested on independent record samples including 1 sample of 22 autopsy cases of pulmonary emphysema. Results were nearly identical. They exceeded those reported in the literature, which may be attributed to the use of more reliable electrocardiographic leads and to application of more efficient multivariate classification procedures." @default.
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• W2109187721 date "1970-01-01" @default.
• W2109187721 modified "2023-10-18" @default.
• W2109187721 title "Computer analysis of the orthogonal electrocardiogram in pulmonary emphysema" @default.
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• W2109187721 doi "https://doi.org/10.1016/0002-9149(70)90812-x" @default.
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